Details of the Drug Combinations

General Information of This Drug (ID: DMGZQEF)

• Drug Name: Mifepristone (DMGZQEF)
• Synonyms: Mifedren; HRA-052015; Mifepristone (Cushing's disease); ACTH modulator (Cushing's disease), HRA; Adrenocorticotropic hormone modulator (Cushing's disease), HRA Pharma; Mifepristone (Cushing's disease), HRA pharma

Indication

Cushing disease; ICD 11: 5A70; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

18 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AS602868 + Mifepristone	DCZ7EPA	AS602868	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Auranofin + Mifepristone	DCN4FPD	Auranofin	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Bardoxolone methyl + Mifepristone	DCGXM5H	Bardoxolone methyl	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
BIIB-021 + Mifepristone	DC43FZC	BIIB-021	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Birinapant + Mifepristone	DCPEYKZ	Birinapant	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Fostamatinib + Mifepristone	DCRVQT1	Fostamatinib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
GDC-0980/RG7422 + Mifepristone	DC9504L	GDC-0980/RG7422	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Gefitinib + Mifepristone	DCWH9M9	Gefitinib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Mebendazole + Mifepristone	DCVP2BS	Mebendazole	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Mefloquine + Mifepristone	DC7JE6B	Mefloquine	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Miconazole + Mifepristone	DC3SHVQ	Miconazole	DD2 (Cell Line: DD2)	[2]
Miconazole + Mifepristone	DCMFIQ0	Miconazole	Hepatoblastoma (Cell Line: HB3)	[3]
Mifepristone + Ciclopirox	DC0854Y	Ciclopirox	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
MLN8237 + Mifepristone	DCO58K2	MLN8237	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
NVP-AUY922 + Mifepristone	DCVX44S	NVP-AUY922	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Parthenolide + Mifepristone	DCMLOJE	Parthenolide	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
RAF265 + Mifepristone	DCRUJU7	RAF265	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
THAPSIGARGIN + Mifepristone	DCT1YLE	THAPSIGARGIN	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Clindamycin + Mifepristone	DC3NV7U	Clindamycin	Retained Products After Miscarriage	[4]
Enzalutamide + Mifepristone	DCZUV4T	Enzalutamide	Hormone-resistant Prostate Cancer	[5]
Itraconazole + Mifepristone	DC5W95F	Itraconazole	Drug Interaction Potentiation	[6]
Mifepristone + Letrozole	DCR8JVT	Letrozole	Complete Abortion	[7]
Mifepristone + Misoprostol	DCPNOQK	Misoprostol	Pregnancy Termination	[8]
Levonorgestrel + Mifepristone	DCQWR4T	Levonorgestrel	Missed Menstrual Period	[9]
Mifepristone + Misoprostol	DC22YJ5	Misoprostol	Medical Abortion	[10]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2805).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT04751500) The HYsteroscopic Miscarriage MaNagement Trial: A Pilot RCT Investigating a Novel Management Pathway for RPOC
• [5] ClinicalTrials.gov (NCT02012296) Enzalutamide and Mifepristone in Treating Patients With Metastatic Hormone Resistant Prostate Cancer
• [6] ClinicalTrials.gov (NCT03259542) Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor
• [7] ClinicalTrials.gov (NCT01475318) Study on Combined Use of Letrozole, Mifepristone and Misoprostol in Termination of Pregnancy
• [8] ClinicalTrials.gov (NCT00680394) Comparing Two Regimens for Medical Abortion: Mifepristone+Misoprostol Versus Misoprostol Alone
• [9] ClinicalTrials.gov (NCT04676776) Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills"
• [10] ClinicalTrials.gov (NCT01856985) Acceptability of an Out-patient Regimen of Medical Abortion With Mifepristone and 800 Mcg Misoprostol Administered at 78-84 Days Gestation