Details of the Drug Combination

General Information of Drug Combination (ID: DC0854Y)

Drug Combination Name
Mifepristone Ciclopirox
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Mifepristone   DMGZQEF Ciclopirox   DMN5T2A
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: SU-DIPG-XIII
Zero Interaction Potency (ZIP) Score: 1.651
Bliss Independence Score: 5.765
Loewe Additivity Score: 1.075
LHighest Single Agent (HSA) Score: 1.032

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Mifepristone
Disease Entry ICD 11 Status REF
Cushing disease 5A70 Approved [2]
Mifepristone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [7]
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Mifepristone Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [9]
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Mifepristone Interacts with 228 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [10]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Increases ADR [11]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Expression [12]
Frizzled-9 (FZD9) OTTZ9MKK FZD9_HUMAN Increases Expression [5]
Forkhead box protein N3 (FOXN3) OTOJYJZP FOXN3_HUMAN Increases Expression [5]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Increases Expression [5]
Actin-binding LIM protein 1 (ABLIM1) OTHXEK3E ABLM1_HUMAN Increases Expression [5]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Increases Expression [5]
Histone-lysine N-methyltransferase 2D (KMT2D) OTTVHCLY KMT2D_HUMAN Decreases Expression [5]
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6) OTSB55D2 H17B6_HUMAN Decreases Expression [5]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Decreases Expression [5]
Calpain-5 (CAPN5) OTQ8QM7K CAN5_HUMAN Decreases Expression [5]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Decreases Expression [5]
Septin-4 (SEPTIN4) OTD16B30 SEPT4_HUMAN Decreases Expression [5]
Cationic amino acid transporter 4 (SLC7A4) OTAVC6QS CTR4_HUMAN Decreases Expression [5]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Decreases Expression [5]
Synaptogyrin-1 (SYNGR1) OT0MBUK5 SNG1_HUMAN Decreases Expression [5]
C-X-C motif chemokine 13 (CXCL13) OT2AT4N8 CXL13_HUMAN Decreases Expression [5]
Frizzled-6 (FZD6) OTBCPII8 FZD6_HUMAN Increases Expression [5]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Increases Expression [5]
Sorting nexin-2 (SNX2) OT889MQA SNX2_HUMAN Increases Expression [5]
P antigen family member 4 (PAGE4) OT2VLWT0 PAGE4_HUMAN Decreases Expression [5]
Slit homolog 3 protein (SLIT3) OTU8MKEU SLIT3_HUMAN Decreases Expression [5]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Decreases Expression [5]
Solute carrier family 22 member 3 (SLC22A3) OTQYGVXX S22A3_HUMAN Decreases Expression [5]
E3 ubiquitin-protein ligase NEURL1 (NEURL1) OT2C4P70 NEUL1_HUMAN Increases Expression [5]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [5]
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3) OTDSN5XF B3GA3_HUMAN Decreases Expression [5]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Decreases Expression [5]
Supervillin (SVIL) OTWQQ1WK SVIL_HUMAN Increases Expression [5]
Follistatin-related protein 3 (FSTL3) OT75489W FSTL3_HUMAN Decreases Expression [5]
Protein LDOC1 (LDOC1) OTWZH4O9 LDOC1_HUMAN Decreases Expression [5]
Coagulation factor XIII A chain (F13A1) OTO8O184 F13A_HUMAN Increases Expression [5]
Tissue-type plasminogen activator (PLAT) OTQPDNAB TPA_HUMAN Increases Expression [5]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [5]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [5]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [5]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Decreases Expression [5]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [5]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [5]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Increases Expression [5]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Decreases Expression [5]
Tyrosine 3-monooxygenase (TH) OT6ZORKP TY3H_HUMAN Decreases Expression [5]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Increases Expression [5]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [5]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [5]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Increases Expression [5]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Increases Expression [5]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [5]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [5]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [5]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [5]
Glutathione S-transferase theta-2 (GSTT2) OTANW3TJ GST2_HUMAN Decreases Expression [5]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [5]
Thyroid hormone receptor alpha (THRA) OTKRLVD7 THA_HUMAN Decreases Expression [5]
Thyroid hormone receptor beta (THRB) OTBBIRHZ THB_HUMAN Increases Expression [5]
Pyruvate carboxylase, mitochondrial (PC) OT6O0V51 PYC_HUMAN Decreases Expression [5]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [5]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [5]
Cytochrome P450 4B1 (CYP4B1) OTJP46CB CP4B1_HUMAN Decreases Expression [5]
Retinoic acid receptor gamma (RARG) OT8LHMDH RARG_HUMAN Decreases Expression [5]
HLA class II histocompatibility antigen, DO beta chain (HLA-DOB) OTKADDUB DOB_HUMAN Decreases Expression [5]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Decreases Expression [5]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Decreases Expression [5]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Decreases Expression [5]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Decreases Expression [5]
Fumarylacetoacetase (FAH) OTGZA1YR FAAA_HUMAN Decreases Expression [5]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Increases Expression [5]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [5]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [5]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Decreases Expression [5]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [5]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Increases Expression [5]
Laminin subunit alpha-2 (LAMA2) OTFROQWE LAMA2_HUMAN Decreases Expression [5]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [5]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [5]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [5]
Collagen alpha-5(IV) chain (COL4A5) OTHG60RE CO4A5_HUMAN Decreases Expression [5]
ER lumen protein-retaining receptor 2 (KDELR2) OT9QW7Q0 ERD22_HUMAN Increases Expression [5]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [5]
Pigment epithelium-derived factor (SERPINF1) OTWZH98J PEDF_HUMAN Decreases Expression [5]
Prostaglandin-H2 D-isomerase (PTGDS) OT71NN7C PTGDS_HUMAN Decreases Expression [5]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Increases Expression [5]
Glutamate receptor 1 (GRIA1) OT85LOCJ GRIA1_HUMAN Decreases Expression [5]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [5]
Prostacyclin receptor (PTGIR) OTWTABYM PI2R_HUMAN Increases Expression [5]
Small ribosomal subunit protein eS10 (RPS10) OTE3VSAH RS10_HUMAN Increases Expression [5]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [5]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Increases Expression [5]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Increases Expression [5]
Heat shock 70 kDa protein 13 (HSPA13) OTYXMC4G HSP13_HUMAN Increases Expression [5]
DNA polymerase delta subunit 2 (POLD2) OTBNASP6 DPOD2_HUMAN Decreases Expression [5]
MARCKS-related protein (MARCKSL1) OT13J2FM MRP_HUMAN Increases Expression [5]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [5]
ADP-ribosylation factor-like protein 4D (ARL4D) OTG5I3KU ARL4D_HUMAN Decreases Expression [5]
Matrix metalloproteinase-14 (MMP14) OT9C197Z MMP14_HUMAN Increases Expression [5]
Matrix metalloproteinase-16 (MMP16) OTSFQ2BJ MMP16_HUMAN Increases Expression [5]
RNA-binding protein Nova-1 (NOVA1) OT6A9KHY NOVA1_HUMAN Increases Expression [5]
Lumican (LUM) OTSRC874 LUM_HUMAN Increases Expression [5]
ATP-citrate synthase (ACLY) OTRL9ZRP ACLY_HUMAN Increases Expression [5]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Increases Expression [5]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [5]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [5]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [5]
Ras-related protein Rap-1b (RAP1B) OTHEIIMM RAP1B_HUMAN Increases Expression [5]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Increases Expression [5]
Large ribosomal subunit protein eL39 (RPL39) OTL8TZHQ RL39_HUMAN Increases Expression [5]
Contactin-associated protein 1 (CNTNAP1) OT5Y03EU CNTP1_HUMAN Decreases Expression [5]
Fractalkine (CX3CL1) OTPLGI0E X3CL1_HUMAN Increases Expression [5]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [5]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Decreases Expression [5]
Rho-related GTP-binding protein RhoG (RHOG) OTJ7J1WA RHOG_HUMAN Decreases Expression [5]
Small EDRK-rich factor 2 (SERF2) OTZQDYCZ SERF2_HUMAN Increases Expression [5]
Norrin (NDP) OTGDJ4US NDP_HUMAN Decreases Expression [5]
Angiopoietin-1 receptor (TEK) OT78YN57 TIE2_HUMAN Increases Expression [5]
Tyrosine-protein kinase BTK (BTK) OTG3CDVK BTK_HUMAN Increases Expression [5]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A) OTSK5GFC P2R3A_HUMAN Increases Expression [5]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Increases Expression [5]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Expression [5]
Sperm-associated antigen 1 (SPAG1) OT29JZKW SPAG1_HUMAN Increases Expression [5]
ATP-binding cassette sub-family C member 8 (ABCC8) OTCWQ54I ABCC8_HUMAN Decreases Expression [5]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) OTTA5C3U AIMP1_HUMAN Increases Expression [5]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Expression [5]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Decreases Expression [5]
Phospholipase D1 (PLD1) OTMVUKW6 PLD1_HUMAN Increases Expression [5]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [5]
Collagen alpha-6(IV) chain (COL4A6) OTUREU5Z CO4A6_HUMAN Decreases Expression [5]
Interleukin-13 receptor subunit alpha-2 (IL13RA2) OTPC2G0X I13R2_HUMAN Increases Expression [5]
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) OT536XAV AR6P1_HUMAN Increases Expression [5]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) OTAP5AT3 PTPRK_HUMAN Increases Expression [5]
P2Y purinoceptor 14 (P2RY14) OTDGZKED P2Y14_HUMAN Increases Expression [5]
Monocyte to macrophage differentiation factor (MMD) OTB5I4OC PAQRB_HUMAN Increases Expression [5]
TSC22 domain family protein 1 (TSC22D1) OTN4GFWD T22D1_HUMAN Increases Expression [5]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Decreases Expression [5]
Mitogen-activated protein kinase 6 (MAPK6) OTDDNF3Q MK06_HUMAN Increases Expression [5]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Decreases Expression [5]
Centrosomal protein kizuna (KIZ) OT5VCKSM KIZ_HUMAN Increases Expression [5]
Carboxypeptidase Z (CPZ) OT5HUR28 CBPZ_HUMAN Increases Expression [5]
F-box only protein 46 (FBXO46) OT773EPG FBX46_HUMAN Decreases Expression [5]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Increases Expression [5]
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6) OTAX8BNJ B3GN6_HUMAN Decreases Expression [5]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Decreases Expression [5]
Kinesin-like protein KIF27 (KIF27) OTV70I2Q KIF27_HUMAN Increases Expression [5]
Osteopetrosis-associated transmembrane protein 1 (OSTM1) OTKNJDH7 OSTM1_HUMAN Increases Expression [5]
Membrane progestin receptor alpha (PAQR7) OTIWX5AM PAQR7_HUMAN Decreases Expression [5]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [5]
RB1-inducible coiled-coil protein 1 (RB1CC1) OTZK8PFX RBCC1_HUMAN Increases Expression [5]
Protein phosphatase 1 regulatory subunit 1C (PPP1R1C) OTVH6BND PPR1C_HUMAN Increases Expression [5]
Kelch-like protein 6 (KLHL6) OTLDECOX KLHL6_HUMAN Increases Expression [5]
C-type lectin domain family 2 member B (CLEC2B) OT0W0M0L CLC2B_HUMAN Increases Expression [5]
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8) OTX1DWEF DHB8_HUMAN Decreases Expression [5]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [5]
Histone deacetylase 2 (HDAC2) OTUYVFKN HDAC2_HUMAN Increases Expression [5]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Increases Expression [5]
Stathmin-2 (STMN2) OT0FUHLH STMN2_HUMAN Increases Expression [5]
Seipin (BSCL2) OT73V6Y4 BSCL2_HUMAN Decreases Expression [5]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Decreases Expression [5]
Mannose-1-phosphate guanyltransferase alpha (GMPPA) OTADC03N GMPPA_HUMAN Decreases Expression [5]
Mastermind-like protein 3 (MAML3) OTZFV53Z MAML3_HUMAN Increases Expression [5]
Translocation protein SEC62 (SEC62) OTCWEL5F SEC62_HUMAN Increases Expression [5]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) OTVFRL8G TI17A_HUMAN Increases Expression [5]
C-C motif chemokine 13 (CCL13) OTNX0JD0 CCL13_HUMAN Decreases Expression [5]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) OTQW6R3Z SGIP1_HUMAN Increases Expression [5]
Receptor expression-enhancing protein 2 (REEP2) OTPCRA5O REEP2_HUMAN Decreases Expression [5]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [5]
Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6) OT57EPQC C1QT6_HUMAN Increases Expression [5]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Decreases Expression [5]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [5]
Netrin-4 (NTN4) OTDRRMP3 NET4_HUMAN Increases Expression [5]
Endothelial cell-specific molecule 1 (ESM1) OT331Y8V ESM1_HUMAN Increases Expression [5]
Exosome complex component RRP46 (EXOSC5) OTADUQ7H EXOS5_HUMAN Decreases Expression [5]
Protein reprimo (RPRM) OTNNBAS1 RPRM_HUMAN Decreases Expression [5]
E3 ubiquitin-protein ligase RNF146 (RNF146) OTE4CO7E RN146_HUMAN Increases Expression [5]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Decreases Expression [5]
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) OT70T27A CKLF6_HUMAN Increases Expression [5]
Ankyrin repeat domain-containing protein 10 (ANKRD10) OTIZ2VK8 ANR10_HUMAN Increases Expression [5]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Decreases Expression [5]
Sentrin-specific protease 1 (SENP1) OTO8J4VV SENP1_HUMAN Increases Expression [5]
Phosphatidylethanolamine N-methyltransferase (PEMT) OTKXRUL9 PEMT_HUMAN Decreases Expression [5]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [5]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Expression [5]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2) OT9PBQVT SIA7B_HUMAN Increases Expression [5]
Polypyrimidine tract-binding protein 2 (PTBP2) OTF4S7NE PTBP2_HUMAN Increases Expression [5]
Frizzled-4 (FZD4) OTGLZIE0 FZD4_HUMAN Increases Expression [5]
Frizzled-10 (FZD10) OTSAENLT FZD10_HUMAN Increases Expression [5]
Lysosomal thioesterase PPT2 (PPT2) OTD5VJ9A PPT2_HUMAN Increases Expression [5]
Sorting nexin-12 (SNX12) OTARRSWB SNX12_HUMAN Decreases Expression [5]
HIG1 domain family member 1A, mitochondrial (HIGD1A) OTS351DV HIG1A_HUMAN Increases Expression [5]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Increases Expression [5]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Decreases Expression [5]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Increases Expression [5]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) OTYOTM2B NUBP2_HUMAN Increases Expression [5]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Decreases Expression [5]
Calcineurin-binding protein cabin-1 (CABIN1) OT4G5CIK CABIN_HUMAN Increases Expression [5]
SEC23-interacting protein (SEC23IP) OTTZ0FXP S23IP_HUMAN Increases Expression [5]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Increases Expression [13]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Decreases Expression [14]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [15]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Expression [16]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [17]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Decreases Expression [18]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [19]
T-cell surface glycoprotein CD4 (CD4) OT7Z5LNF CD4_HUMAN Decreases Expression [20]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [21]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Activity [22]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Decreases Activity [23]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [24]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Decreases Activity [25]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [26]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [27]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Decreases Expression [28]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Activity [19]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Decreases Expression [24]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [29]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [30]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [26]
Cathelicidin antimicrobial peptide (CAMP) OT3Y8011 CAMP_HUMAN Decreases Expression [18]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Increases Expression [30]
Neutrophil defensin 1 (DEFA1) OT5N1B9B DEF1_HUMAN Decreases Expression [18]
Neutrophil defensin 3 (DEFA3) OTO3N8E1 DEF3_HUMAN Decreases Expression [18]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [27]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [26]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Increases Expression [31]
Progesterone-induced-blocking factor 1 (PIBF1) OTCBT1A1 PIBF1_HUMAN Decreases Expression [18]
Interleukin-1 receptor-associated kinase 4 (IRAK4) OT9JTJWC IRAK4_HUMAN Decreases Expression [18]
Toll-like receptor 7 (TLR7) OT3HZV7Z TLR7_HUMAN Decreases Expression [18]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Increases Response To Substance [32]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Increases Response To Substance [32]
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⏷ Show the Full List of 228 DOT(s)
Indication(s) of Ciclopirox
Disease Entry ICD 11 Status REF
Cutaneous candidiasis 1F23.14 Approved [3]
Fungal infection 1F29-1F2F Approved [4]
Mycoses 1F2Z Approved [3]
Onychomycosis EE12.1 Approved [3]
Pityriasis simplex N.A. Approved [3]
Tinea corporis 1F28.Y Approved [3]
Tinea cruris 1F28.3 Approved [3]
Tinea versicolor 1F2D.0 Approved [3]
Tinea pedis 1F28.2 Investigative [3]
Ciclopirox Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Modulator [33]
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Ciclopirox Interacts with 6 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [34]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Activity [35]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [36]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Degradation [37]
Microtubule-associated protein tau (MAPT) OTMTP2Z7 TAU_HUMAN Decreases Expression [38]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Stability [39]
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⏷ Show the Full List of 6 DOT(s)

References

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3 Ciclopirox FDA Label
4 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076435.
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