Details of the Drug Combinations

General Information of This Drug (ID: DMITQS0)

• Drug Name: Lopinavir (DMITQS0)
• Synonyms: AIDS032937; Aluvia (TN); Aluviran; Kaletra (TN); Koletra; LPV; Lopinavir (JAN/USAN/INN); Lopinavir [USAN:INN:BAN]; RS-346; A 157378; A 157378.0; A-157378-0; A-157378.0; ABT 157378; ABT 378; ABT-378; ABT-378

Indication

Human immunodeficiency virus infection; ICD 11: 1C62; Status: Approved [1]; Middle East Respiratory Syndrome (MERS); ICD 11: 1D64; Status: Preclinical [2]; Severe acute respiratory syndrome (SARS); ICD 11: 1D65; Status: Preclinical [2]

• Therapeutic Class: Anti-HIV Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

4 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Lopinavir + Ritonavir	DCCA3OM	Ritonavir	Middle East Respiratory Syndrome (MERS) (Cell Line: .)	[3]
Lopinavir + Idarubicin	DCVEC89	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]
Lopinavir + Interferon alpha	DCHBQC5	Interferon alpha	Coronavirus Disease 2019 (COVID-19) (Cell Line: .)	[5]
Ribavirin + Lopinavir	DCPFIBN	Ribavirin	Middle East Respiratory Syndrome (MERS) (Cell Line: .)	[2]

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Emtricitabine + Lopinavir	DC36BFO	Emtricitabine	Acute HIV Infection	[6]
Emtricitabine + Lopinavir	DCKSN07	Emtricitabine	Acute HIV Infection	[6]
Lamivudine + Lopinavir	DCGKJVN	Lamivudine	Human immunodeficiency virus-1 infection	[7]
Lopinavir + Maraviroc	DCE11ZR	Maraviroc	HIV Infections	[8]
Lopinavir + Buprenorphine	DC13ZKW	Buprenorphine	HIV Infections	[9]
Lopinavir + Raltegravir	DC3HPZB	Raltegravir	Human Immunodeficiency Virus Infection	[10]
Lopinavir + Isavuconazole	DC4WEP9	Isavuconazole	Pharmacokinetics of Isavuconazole	[11]
Lopinavir + Ritonavir	DCDVYC4	Ritonavir	Brain Tumor	[12]
Rifabutin + Lopinavir	DC6HB95	Rifabutin	HIV	[13]
Interferon beta-1b + Lopinavir	DCP0SF9	Interferon beta-1b	Middle East Respiratory Syndrome (MERS)	[14]
Lopinavir + Azithromycin	DCHOB2C	Azithromycin	COVID	[15]
Favipiravir + Lopinavir	DC0JRWJ	Favipiravir	Coronavirus Disease 2019 (COVID-19)	[16]
Lopinavir + Lopinavir	DCC8PUG	Lopinavir	HIV-1 Infection	[17]
Lopinavir + Oseltamivir	DCMK65W	Oseltamivir	Coronavirus Disease 2019 (COVID-19)	[16]
Lopinavir + Ritonavir	DC1SBRY	Ritonavir	Coronavirus Disease 2019 (COVID-19)	[18]

References

• [1] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [2] Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
• [3] Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020 Jan 10;11(1):222.
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT04275388) Xiyanping Injection for the Treatment of New Coronavirus Infected Pneumonia
• [6] ClinicalTrials.gov (NCT01154673) Effects of Intensive cART During Acute/Early HIV Infection
• [7] ClinicalTrials.gov (NCT00043953) Lopinavir/Ritonavir in Combination With Saquinavir Mesylate or Lamivudine/Zidovudine to Explore Metabolic Toxicities in Antiretroviral HIV-Infected Subjects. U.S. National Institutes of Health.
• [8] ClinicalTrials.gov (NCT00977756) IMPAACT P1058A: Pharmacokinetic Effects of New Antiretroviral Drugs on Children, Adolescents and Young Adults
• [9] ClinicalTrials.gov (NCT00571961) Pharmacokinetic Interactions Between Buprenorphine and Kaletra (Lopinavir/Ritonavir)
• [10] ClinicalTrials.gov (NCT00711009) Study Comparing Lopinavir/Ritonavir (LPV/r) + Emtricitabine/Tenofovir Disoproxil Fumarate (FTC/TDF) With a Nucleoside Sparing Regimen Consisting of Lopinavir/Ritonavir + Raltegravir (RAL)
• [11] ClinicalTrials.gov (NCT01660477) Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole
• [12] ClinicalTrials.gov (NCT01095094) Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade Glioma
• [13] ClinicalTrials.gov (NCT00743470) A Bioavailability Study of Rifabutin and Lopinavir/Ritonavir in Healthy Adult Subjects
• [14] ClinicalTrials.gov (NCT02845843) MERS-CoV Infection tReated With A Combination of Lopinavir /Ritonavir and Interferon Beta-1b
• [15] ClinicalTrials.gov (NCT04459702) A Study of Combination Therapies to Treat COVID-19 Infection
• [16] ClinicalTrials.gov (NCT04303299) Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial
• [17] ClinicalTrials.gov (NCT01352715) Study of Options for Second-Line Effective Combination Therapy (SELECT)
• [18] ClinicalTrials.gov (NCT04315948) Trial of Treatments for COVID-19 in Hospitalized Adults