Details of the Drug Combinations

General Information of This Drug (ID: DMIW453)

Drug Name
Pelitinib   DMIW453
Synonyms EKB-569; EKI-569; WAY-EKB-569
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

46 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Pelitinib DCTO0H5 (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + Pelitinib DCEC5B4 ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
ABT-263 + Pelitinib DC7G0RK ABT-263 Glioblastoma (Cell Line: JHH-136) [3]
AZD8055 + Pelitinib DCC2IIB AZD8055 Glioblastoma (Cell Line: JHH-136) [2]
Bardoxolone methyl + Pelitinib DCQBWKY Bardoxolone methyl Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + Pelitinib DCMRBMR BIIB-021 Glioblastoma (Cell Line: JHH-136) [2]
Cantharidin + Pelitinib DC9KRHM Cantharidin Ewing sarcoma (Cell Line: TC-71) [2]
Efaproxyn + Pelitinib DCGEQK7 Efaproxyn Ewing sarcoma (Cell Line: TC-71) [2]
Everolimus + Pelitinib DCM5YIY Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Exherin + Pelitinib DCPYHB2 Exherin Ewing sarcoma (Cell Line: TC-71) [2]
GDC0941 + Pelitinib DCI02WW GDC0941 Glioblastoma (Cell Line: JHH-136) [2]
LY2523355 + Pelitinib DC5VB5Y LY2523355 Ewing sarcoma (Cell Line: TC-71) [2]
LY2874455 + Pelitinib DCDCH9E LY2874455 Ewing sarcoma (Cell Line: TC-71) [2]
Mebendazole + Pelitinib DCDXSVB Mebendazole Glioblastoma (Cell Line: JHH-136) [2]
MK-2206 + Pelitinib DCCZMX5 MK-2206 Ewing sarcoma (Cell Line: TC-71) [2]
Nintedanib + Pelitinib DC5V5MN Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
Panobinostat + Pelitinib DCEWAUZ Panobinostat Hodgkin lymphoma (Cell Line: HDLM-2) [3]
Pelitinib + Buparlisib DC8RO3Z Buparlisib Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Trametinib DC1EOE7 Trametinib Glioblastoma (Cell Line: JHH-136) [2]
Pelitinib + Cladribine DC5SCNS Cladribine Glioblastoma (Cell Line: JHH-136) [2]
Pelitinib + Carfilzomib DC96ANY Carfilzomib Glioblastoma (Cell Line: JHH-136) [2]
Pelitinib + Panobinostat DCB4U3Z Panobinostat Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Pralatrexate DCR2NYO Pralatrexate Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + AT7519 DCCU40S AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + SCH 727965 DCMJ4VA SCH 727965 Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Daporinad DCEBVGB Daporinad Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + PHA-739358 DCDKE7G PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Mitomycin DC1LNQ1 Mitomycin Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + OSI-906 DCO5Q6Q OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + GSK2126458 DCCQHDB GSK2126458 Glioblastoma (Cell Line: JHH-136) [2]
Pelitinib + ABT-263 DCB57AA ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Ispinesib DC6MNHW Ispinesib Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Decitabine DCJ4OCO Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Mitotane DCTY3BQ Mitotane Ewing sarcoma (Cell Line: TC-71) [2]
Pelitinib + Panobinostat DCDW4V5 Panobinostat Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + Ym155 DC0I46N Ym155 Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + GDC-0084 DCX7EN8 GDC-0084 Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + Nilutamide DCTKUPP Nilutamide Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + Vincristine DCDRNQT Vincristine Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + Azathioprine DCTN28S Azathioprine Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + ABT-263 DC5H5GM ABT-263 Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + Bortezomib DC170M6 Bortezomib Hodgkin lymphoma (Cell Line: L-1236) [3]
Pelitinib + Sapanisertib DCKHUVA Sapanisertib Hodgkin lymphoma (Cell Line: L-1236) [3]
Plinabulin + Pelitinib DC0E12L Plinabulin Glioblastoma (Cell Line: JHH-136) [2]
Vincristine + Pelitinib DC72IAJ Vincristine Hodgkin lymphoma (Cell Line: U-HO1) [2]
Withaferin A + Pelitinib DCUPUI3 Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 46 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Pelitinib + Temsirolimus DCQIQ6F Temsirolimus Unspecified Adult Solid Tumor, Protocol Specific [4]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7644).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT00098501) CCI-779 and EKB-569 in Treating Patients With Advanced Solid Tumors