Details of the Drug Combinations

General Information of This Drug (ID: DMJX3O8)

Drug Name
OSI-027   DMJX3O8
Indication
Disease Entry ICD 11 Status REF
Renal cell carcinoma 2C90 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

31 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + OSI-027 DC01OF7 ABT-263 Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + OSI-027 DCY2Z31 ABT-263 Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + OSI-027 DC5IV1B BIIB-021 Glioblastoma (Cell Line: JHH-136) [3]
CA4P + OSI-027 DCLUSNN CA4P Glioblastoma (Cell Line: JHH-136) [3]
Fenretinide + OSI-027 DCPCRH8 Fenretinide Glioblastoma (Cell Line: JHH-136) [3]
Mebendazole + OSI-027 DC2PX3J Mebendazole Glioblastoma (Cell Line: JHH-136) [3]
OSI-027 + Ruxolitinib DC5H6WN Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
OSI-027 + AT13387 DC2BFMP AT13387 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Trametinib DCOT0BD Trametinib Glioblastoma (Cell Line: JHH-136) [3]
OSI-027 + MK-1775 DCLRWH0 MK-1775 Hodgkin lymphoma (Cell Line: U-HO1) [3]
OSI-027 + Panobinostat DCEXHQI Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
OSI-027 + Acalabrutinib DCB26XH Acalabrutinib Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
OSI-027 + Everolimus DCEVWJY Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + TAK-733 DC1J0UP TAK-733 Glioblastoma (Cell Line: JHH-136) [3]
OSI-027 + Evacetrapib DCDAEEB Evacetrapib Glioblastoma (Cell Line: JHH-136) [3]
OSI-027 + LY2523355 DCDOYAE LY2523355 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Mitomycin DCLHT13 Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
OSI-027 + OSI-906 DCWAMNX OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + SNX-5422 DCUTGT1 SNX-5422 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Verteporfin DCH4415 Verteporfin Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Idarubicin DCTVT57 Idarubicin Glioblastoma? (Cell Line: T98G) [3]
OSI-027 + Mebendazole DC507E8 Mebendazole Glioblastoma (Cell Line: JHH-136) [3]
OSI-027 + Bardoxolone methyl DCUPA0V Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Bardoxolone methyl DC1LJNL Bardoxolone methyl Hodgkin lymphoma (Cell Line: U-HO1) [3]
OSI-027 + (-)-englerin A DC3EM7S (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Lestaurtinib DC6WBB2 Lestaurtinib Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Romidepsin DC4KHH3 Romidepsin Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Ibrutinib DC72HKZ Ibrutinib Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
Piperaquine + OSI-027 DCVX1HJ Piperaquine Glioblastoma (Cell Line: JHH-136) [3]
Topetecan + OSI-027 DCH5GER Topetecan Glioblastoma (Cell Line: JHH-136) [3]
Vorinostat + OSI-027 DC8QV3H Vorinostat Glioblastoma (Cell Line: JHH-136) [3]
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⏷ Show the Full List of 31 DrugCom(s)

References

1 Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin. Mol Cancer Ther. 2011 Aug;10(8):1394-406.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.