Details of the Drug Combinations

General Information of This Drug (ID: DMJX6ZG)

Drug Name

Codeine DMJX6ZG

Synonyms

codeine; Methylmorphine; Codeine anhydrous; Codicept; l-Codeine; Coducept; Morphine monomethyl ether; Morphine 3-methyl ether; 76-57-3; (-)-Codeine; O3-Methylmorphine; codeinum; Morphine-3-methyl ether; Codein; Norcodine, N-methyl; Norcodeine, N-methyl; CODEINE BASE; Codeine polistirex; codeina; O(3)-methylmorphine; CCRIS 7555; Morphine-3-methyl ester; HSDB 3043; UNII-UX6OWY2V7J; CHEBI:16714; EINECS 200-969-1; UX6OWY2V7J; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)-; Codeine Anhydrate

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1]
Common cold	CA00	Approved	[1]
Fever	MG26	Approved	[1]
Headache	8A80-8A84	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]
Rhinitis	FA20	Approved	[1]
Cough	MD12	Phase 1	[2]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Codeine + Naloxegol	DCJS6YP	Naloxegol	Constipation Drug Induced	[3]
Codeine + Acetaminophen	DCHRPGA	Acetaminophen	Myopia	[4]
Metamizole + Codeine	DCKJF6Q	Metamizole	Pain, Postoperative	[5]
Codeine + Naloxegol	DCFBBW7	Naloxegol	Opioid-Induced Constipation	[6]
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References

1	Codeine FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1673).
3	ClinicalTrials.gov (NCT02737059) Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects
4	ClinicalTrials.gov (NCT02625753) Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain
5	ClinicalTrials.gov (NCT04641338) Fixed Combination of Dipirone and Codeine Compared to the Isolated Use of Dipyrone and Codeine in Controlling Pain After Pelvic-abdominal Surgery.
6	ClinicalTrials.gov (NCT05770960) Colonic Motor Patterns in Healthy Volunteers