Details of the Drug Combinations

General Information of This Drug (ID: DMK1GBJ)

Drug Name
Trazodone   DMK1GBJ
Synonyms
Beneficat; Desirel; Sideril; Tradozone; Trazalon; Trazodil; Trazodon; Trazodona; Trazodonum; Trazolan; Trazonil; Trialodine; Trittico; Desyrel Dividose; Trazodona [Spanish]; Trazodone Hcl; Trazodonum [Latin]; Beneficat (TN); Deprax (TN); Desirel (TN); Desyrel (TN); Desyrel(trazodone hcl salt); Molipaxin (TN); Thombran (TN); Trazodona [INN-Spanish]; Trazodone (Desyrel); Trazodone (INN); Trazodone [INN:BAN]; Trazodonum [INN-Latin]; Trazorel (TN); Trialodine (TN); Trittico (TN); 2-(3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl)[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 8-[3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl]-1,7,8-triazabicyclo[4.3.0]nona-2,4,6-trien-9-one hydrochloride
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Therapeutic Class
Antidepressants
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

48 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acarbose + Trazodone DCQIXFF Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + Trazodone DCSBRRS Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Trazodone DCD1WL1 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Trazodone DCE7MMK Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bosentan + Trazodone DCER7QL Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Trazodone DCSUUJI Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Trazodone DCK9ZR2 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Crotamiton + Trazodone DC5U3WE Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Trazodone DCW4FP4 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + Trazodone DC57DZD Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Emetine + Trazodone DCHKL4P Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Everolimus + Trazodone DCHL69Q Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fosfomycin + Trazodone DCHUWH3 Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Trazodone DC5MP5E Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Isoproterenol + Trazodone DCSR8H1 Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + Trazodone DCWWI44 Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methocarbamol + Trazodone DCZ7P3Z Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Trazodone DCRJDWY Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + Trazodone DCE44R7 Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + Trazodone DCMK9KV Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Palonosetron + Trazodone DCBS9HV Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + Trazodone DCF2ZI5 PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Trazodone DCAPIZS PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Trazodone DCJ9SSA Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Trazodone DC1845W Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Trazodone DCHDYPZ Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testosterone + Trazodone DCSDI3B Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Gefitinib DC8V1M5 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Diethylcarbamazine DCBFT3C Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Ruxolitinib DCBNAQU Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
Trazodone + Sivelestat DC2TUR3 Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Daidzin DCHRY4F Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Arfolitixorin DC4Y591 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Oseltamivir DCGJ51C Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Fenoprofen DCBGHWG Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Probenecid DCMV1JH Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Methylene blue DC9XPC8 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Amiloride DCZ5T7N Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Brincidofovir DCOQ068 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Mycophenolic acid DCLCH8T Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trazodone + Atovaquone DC6Q2M6 Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + Trazodone DCLC8TD Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + Trazodone DC7B9QS Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Trazodone DCK9QL6 Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ursodeoxycholic acid + Trazodone DCZTCGY Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Trazodone DCVY65Q Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Trazodone DCHDM8B Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
VR-776 + Trazodone DCT1OI7 VR-776 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 48 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Trazodone + Zolpidem DCIQGWI Zolpidem Chronic Insomnia [4]
Trazodone + Risperidone DCOIUVL Risperidone Delirium [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 213).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT04468776) CBT-I or Zolpidem/Trazodone for Insomnia
5 ClinicalTrials.gov (NCT02118688) Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium