Details of the Drug Combinations

General Information of This Drug (ID: DMK8U72)

• Drug Name: Labetalol (DMK8U72)
• Synonyms: Albetol; Ibidomide; Labetalolum; Labetolol; NORMOZIDE; AH 5158; AH-5158; Labetalol (INN); Labetalol [INN:BAN]; Labetalolum [INN-Latin]; Normodyne (TN); Sch-19927; Trandate (TN); 2-Hydroxy-5-(1-hydroxy-2-((1-methyl-3-phenylpropyl)amino)ethyl)benzamide; 2-hydroxy-5-[1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl]benzamide; 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide; 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol; 5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide

Indication

Hypertension; ICD 11: BA00-BA04; Status: Approved [1]; Hypertension, pregnancy-induced; ICD 11: N.A.; Status: Approved [2]; Malignant essential hypertension; ICD 11: BA00; Status: Approved [2]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Esmolol + Labetalol	DCK8EQ6	Esmolol	Laparoscopic Surgery	[3]
Fentanyl + Labetalol	DCNO8W3	Fentanyl	Laparoscopic Surgery	[3]
Labetalol + Atenolol	DC5BEWA	Atenolol	Systolic Hypertension	[4]
Labetalol + Atenolol	DCFSHSV	Atenolol	Obesity, Morbid	[5]
Labetalol + Enalapril	DCGWYPM	Enalapril	Stroke, Acute	[6]
Labetalol + Nifedipine	DCD9ZG7	Nifedipine	Elevated Blood Pressure	[7]
Nicardipine + Labetalol	DC8XNAO	Nicardipine	Acute Stroke	[8]
Labetalol + Furosemide	DCFX5DT	Furosemide	Hypertension, Pregnancy-Induced	[9]
Methyldopa + Labetalol	DCFFSPE	Methyldopa	Hypertension, Pregnancy-Induced	[10]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7207).
• [2] Labetalol FDA Label
• [3] ClinicalTrials.gov (NCT01114971) Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
• [4] ClinicalTrials.gov (NCT04755764) Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy
• [5] ClinicalTrials.gov (NCT03105661) Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients
• [6] ClinicalTrials.gov (NCT04484350) Blood Pressure Management in Stroke Following Endovascular Treatment
• [7] ClinicalTrials.gov (NCT05955040) Treatment of Elevated Blood Pressures in Early Pregnancy
• [8] ClinicalTrials.gov (NCT04116112) Blood Pressure After Endovascular Stroke Therapy-II
• [9] ClinicalTrials.gov (NCT04343235) Postpartum Management of Gestational Hypertensive Disorders Using Furosemide
• [10] ClinicalTrials.gov (NCT02531490) Early Vascular Adjustments During Hypertensive Pregnancy