Details of the Drug Combinations

General Information of This Drug (ID: DMKA8R4)

Drug Name
SB 228357   DMKA8R4
Synonyms SB-228357; SB228357
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

31 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Dihydroergotamine + SB 228357 DCCTEKT Dihydroergotamine DD2 (Cell Line: DD2) [2]
Dihydroergotamine + SB 228357 DCOUAC8 Dihydroergotamine Hepatoblastoma (Cell Line: HB3) [2]
Miconazole + SB 228357 DCXQEQL Miconazole DD2 (Cell Line: DD2) [2]
Miconazole + SB 228357 DC526CX Miconazole Hepatoblastoma (Cell Line: HB3) [3]
Proguanil + SB 228357 DCOIDN5 Proguanil DD2 (Cell Line: DD2) [2]
Proguanil + SB 228357 DCMSJ0C Proguanil Hepatoblastoma (Cell Line: HB3) [2]
SB 228357 + Verapamil DCRIXDN Verapamil DD2 (Cell Line: DD2) [2]
SB 228357 + Thiolactomycin DCQZ8OU Thiolactomycin DD2 (Cell Line: DD2) [2]
SB 228357 + Proguanil DC7IGTU Proguanil DD2 (Cell Line: DD2) [2]
SB 228357 + Miconazole DCZ48VV Miconazole DD2 (Cell Line: DD2) [2]
SB 228357 + Quinine DCMD9YY Quinine DD2 (Cell Line: DD2) [2]
SB 228357 + MK-4815 DCWQNXU MK-4815 DD2 (Cell Line: DD2) [2]
SB 228357 + Bifemelane DCX5BX5 Bifemelane DD2 (Cell Line: DD2) [2]
SB 228357 + Ritonavir DCF6NVM Ritonavir DD2 (Cell Line: DD2) [2]
SB 228357 + Atovaquone DCRZ57M Atovaquone DD2 (Cell Line: DD2) [2]
SB 228357 + Lumefantrine DC774SR Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + T-3.5 DCVQUGZ T-3.5 Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Artemether DCHVQG4 Artemether Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Thiolactomycin DCP5KZ6 Thiolactomycin Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Proguanil DCIUDJ1 Proguanil Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Epothilone B DC7T2PG Epothilone B Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Miconazole DCCV1DO Miconazole Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + MK-4815 DC0JQD2 MK-4815 Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Ritonavir DCF70AB Ritonavir Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Nitisinone DCLUBQZ Nitisinone Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Vorinostat DCQRTST Vorinostat Hepatoblastoma (Cell Line: HB3) [3]
SB 228357 + Atovaquone DC1J3OG Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Sorafenib + SB 228357 DCE2MLJ Sorafenib Hepatoblastoma (Cell Line: HB3) [2]
Verapamil + SB 228357 DCA3C5U Verapamil DD2 (Cell Line: DD2) [3]
Verapamil + SB 228357 DC53SQ6 Verapamil Hepatoblastoma (Cell Line: HB3) [3]
ZM-447439 + SB 228357 DC2ZSXD ZM-447439 DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 31 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 192).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.