Details of the Drug Combinations

General Information of This Drug (ID: DMKXDOI)

Drug Name
AS602868   DMKXDOI
Synonyms
Angelicin; ISOPSORALEN; 523-50-2; 2H-Furo[2,3-H]chromen-2-one; Angecin; furo[2,3-h]chromen-2-one; Isopsoralin; Furo(2,3-h)coumarin; Angelecin; Angelicin (coumarin derivative); 2H-Furo[2,3-H]-1-benzopyran-2-one; 2-Oxo-(2H)-furo(2,3-h)-1-benzopyran; UNII-CZZ080D7BD; Angelicin (coumarin deriv); NSC 404563; Furo(5',4':7,8)coumarin; CCRIS 4276; HSDB 3554; 4-Hydroxy-5-benzofuranacrylic acid gamma-lactone; BRN 0153970; CZZ080D7BD; 2H-Furo(2,3-H)-1-benzopyran-2-one; CHEMBL53569; Furo[5',4':7,8]coumarin; Isopsoralen
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Discontinued in Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

40 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + AS602868 DCB7DQM ABT-263 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
ABT-263 + AS602868 DCRTZ3D ABT-263 Glioblastoma (Cell Line: JHH-136) [2]
AS602868 + Ruxolitinib DCCC0N9 Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [3]
AS602868 + Trametinib DCZ30IT Trametinib Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + Carfilzomib DCD6UC4 Carfilzomib Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + Panobinostat DC0ZK7C Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
AS602868 + Panobinostat DC9YDTW Panobinostat Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + AZD8055 DCCA682 AZD8055 Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + TAK-733 DCANRN8 TAK-733 Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + Mifepristone DCZ7EPA Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
AS602868 + Mitomycin DCZXMEI Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
AS602868 + Flavopiridol DCA05T8 Flavopiridol Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + GSK2126458 DCY873U GSK2126458 Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + Ciclopirox DC5VY16 Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
AS602868 + Bardoxolone methyl DCIALJR Bardoxolone methyl Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + Fenretinide DCAYKTD Fenretinide Glioblastoma (Cell Line: JHH-136) [3]
AS602868 + Prazosin DCQHEB2 Prazosin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
AS602868 + Mefloquine DC7M053 Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
AS602868 + Ruxolitinib DCK7JSQ Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
AS602868 + Ym155 DCMHEUA Ym155 Hodgkin lymphoma (Cell Line: L-1236) [2]
AS602868 + Azathioprine DCQEMWJ Azathioprine Hodgkin lymphoma (Cell Line: L-1236) [2]
Bardoxolone methyl + AS602868 DCFIJLO Bardoxolone methyl Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bleomycin + AS602868 DC8K4QW Bleomycin Hodgkin lymphoma (Cell Line: L-1236) [2]
BMS-754807 + AS602868 DCZH4EO BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
CA4P + AS602868 DCAH5I9 CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
CP-673451 + AS602868 DCCO2HG CP-673451 Hodgkin lymphoma (Cell Line: L-1236) [3]
CUDC-101 + AS602868 DC3D2OI CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Dasatinib + AS602868 DCWQB98 Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Dorsomorphin + AS602868 DC3JYX3 Dorsomorphin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
IMD-0354 + AS602868 DCTWBVI IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
IMD-0354 + AS602868 DCV0KFH IMD-0354 Hodgkin lymphoma (Cell Line: L-1236) [2]
JQ1 + AS602868 DCXEB2O JQ1 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Marizomib + AS602868 DC7YFKB Marizomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Parthenolide + AS602868 DCNZAEL Parthenolide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
PF-04691502 + AS602868 DCTJHV3 PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
RAF265 + AS602868 DCCX80W RAF265 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Raloxifene + AS602868 DC602F8 Raloxifene Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
SCH 727965 + AS602868 DC1BFOC SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
SNDX-275 + AS602868 DC0BLXA SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Trametinib + AS602868 DCMSVVY Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
------------------------------------------------------------------------------------
⏷ Show the Full List of 40 DrugCom(s)

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009941)
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.