Details of the Drug Combinations

General Information of This Drug (ID: DMKXY2R)

Drug Name
Ibutilide   DMKXY2R
Synonyms
Corvert; Ibutilida; Ibutilidum; Butilide fumarate; IBUTILIDE FUMARATE; Ibutilide Fumarate [USAN]; U 70226E; U82208E; U82209E; Corvert (TN); Ibutilida [INN-Spanish]; Ibutilide (INN); Ibutilide [BAN:INN]; Ibutilide [INN:BAN]; Ibutilide fumarate (USAN); Ibutilidum [INN-Latin]; U-70226E; U-82208E; U-82209E; Ibutilide, (+-)-isomer; N-[4-[4-[ethyl(heptyl)amino]-1-hydroxybutyl]phenyl]methanesulfonamide; Ibutilide, fumarate salt (2:1), (+-)-isomer; N-(4-(4-(ethylheptylamino)-1-hydroxybutyl)phenyl)methanesulfonamide; N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide; Methanesulfonamide, N-(4-(4-(ethylheptylamino)-1-hydroxybutyl)phenyl)-, (E)-2-butenedioate (2:1) (salt); Methanesulfonamide, N-(4-(4-(ethylheptylamino)-1-hydroxybutyl)phenyl)-, (+-)-, (E)-2-butenedioate (2:1) (salt); Methanesulfonamide, N-(4-(4-(ethylheptylamino)-1-hydroxybutyl)phenyl)-, (+-)-,(E)-2-butenedioate (2:1) (salt); (+-)-4'-(4-(Ethylheptylamino)-1-hydroxybutyl)methanesulfoanilide (E)-2-butenedioate (2:1); (+-)-4'-(4-(Ethylheptylamino)-1-hydroxybutyl)methanesulfonanilide fumarate (2:1) (salt); (+-)-N-(4-(4-(Ethylheptylamino)-1-hydroxybutyl)phenyl)methanesulfonamide (E)-butenedioate
Indication
Disease Entry ICD 11 Status REF
Atrial fibrillation BC81.3 Approved [1]
Therapeutic Class
Antiarrhythmic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

60 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Ibutilide DCA5V76 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acetohydroxamic Acid + Ibutilide DC4WE6G Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Artemisinin + Ibutilide DCUVK19 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
AS-1949490 + Ibutilide DCHCMTG AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Ibutilide DCT9VT1 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Ibutilide DCI8NHK Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Ibutilide DC0CQEK Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Ibutilide DCFL3XB Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diphenidol + Ibutilide DC3ZA5T Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eflornithine + Ibutilide DCDO49H Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + Ibutilide DCY9NJL Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Ibutilide DCNH405 Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Mebutamate DC8BKK2 Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Gefitinib DCV76E3 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Dantrolene DCQIJ9G Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Ruxolitinib DCDR16U Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
Ibutilide + Panobinostat DCPC4VF Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Ibutilide + Acitretin DCPVQK2 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Everolimus DCMB3PT Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Pepstatin DCWWO7F Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Metyrosine DCMDUMR Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Emetine DC7XGLZ Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Metformin DCDUWH2 Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Docetaxel DCY4F9G Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Cilastatin DCEOLC7 Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Dichlorphenamide DCAK31I Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Tolazoline DCSW1LS Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Arfolitixorin DC5RY02 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Diazoxide DCCIG48 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Allopurinol DCQAULI Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Methylene blue DCHMBVJ Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Tropisetron DCLTV0M Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Maprotiline DC4K716 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Eptifibatide DCEC3YB Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Acarbose DCRHF47 Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Brincidofovir DCD3IVO Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Hyodeoxycholic acid DC8RG1C Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Asenapine DCIHHIK Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Quinine DCJZX0Y Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Spironolactone DCSEEW0 Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Mycophenolic acid DC7GF6W Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Cisatracurium DCH3HGC Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Doxorubicin DC491O9 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Iloprost DCMLWZU Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Auranofin DCBZXZO Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Hydroxychloroquine DCKWPW8 Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Ibutilide DCQTGF0 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Ibutilide DC7J5W9 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + Ibutilide DCG9ZH7 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mesalazine + Ibutilide DCGI3KU Mesalazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Ibutilide DCWN6TF Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Paromomycin + Ibutilide DCAT0AN Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pazopanib + Ibutilide DCJFO90 Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Ibutilide DC1K3VJ PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Probenecid + Ibutilide DC9E2SG Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Teriflunomide + Ibutilide DC7O7TA Teriflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Ibutilide DCIBQG2 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Ibutilide DCH2NUP Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Ibutilide DCOPD18 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Zileuton + Ibutilide DC0R4MJ Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 60 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Progesterone + Ibutilide DCPV6RQ Progesterone Prolonged QT Interval in EKG and Sudden Death [3]
Progesterone + Ibutilide DCGQYHX Progesterone Long QT Syndrome [4]
Testosterone + Ibutilide DC1S7B9 Testosterone Long QT Syndrome [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7200).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 ClinicalTrials.gov (NCT01929083) Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening
4 ClinicalTrials.gov (NCT03834883) Reducing the Risk of Drug-Induced QT Interval Lengthening in Women
5 ClinicalTrials.gov (NCT04675788) Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening