Details of the Drug Combinations

General Information of This Drug (ID: DMKYXJW)

Drug Name

Dorsomorphin DMKYXJW

Synonyms

dorsomorphin; 866405-64-3; 6-(4-(2-(Piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine; BML-275; Compound C; AMPK Inhibitor, Compound C; 6-[4-(2-Piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine; CHEMBL478629; CHEBI:78510; 4-(6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}pyrazolo[1,5-a]pyrimidin-3-yl)pyridine; 6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyrrazolo[1,5-a]-pyrimidine; AMPK Inhibitor

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dorsomorphin + NUTLIN-3	DCH2SH5	NUTLIN-3	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + RTB101	DCS5M9R	RTB101	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + RTB101	DCPY0K2	RTB101	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Dorsomorphin + CUDC-101	DCY6SUZ	CUDC-101	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + CUDC-101	DCOAHLU	CUDC-101	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Dorsomorphin + SCH 727965	DCNT2HT	SCH 727965	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + Palbociclib	DCYBB18	Palbociclib	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + Palbociclib	DCW91GI	Palbociclib	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Dorsomorphin + AS602868	DC3JYX3	AS602868	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + IMD-0354	DCTV84M	IMD-0354	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + BMS-754807	DCLBIKJ	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + BMS-754807	DC5QY71	BMS-754807	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
Dorsomorphin + CPG 52364	DCLHALR	CPG 52364	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Dorsomorphin + Vinpocetine	DC11E9A	Vinpocetine	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Raloxifene + Dorsomorphin	DC68VCS	Raloxifene	Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII)	[2]
Raloxifene + Dorsomorphin	DCA8TST	Raloxifene	Primitive neuroectodermal tumor (Cell Line: TC-32)	[2]
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⏷ Show the Full List of 16 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4907).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.