Details of the Drug Combinations

General Information of This Drug (ID: DML0B41)

Drug Name

Naloxegol DML0B41

Synonyms

NKTR-118

Indication

Disease Entry	ICD 11	Status	REF
Opioid-induced constipation	DB32.1	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Codeine + Naloxegol	DCJS6YP	Codeine	Constipation Drug Induced	[2]
Naloxegol + Ketoconazole	DCR1TYB	Ketoconazole	Bioavailability	[3]
Rifampicin + Naloxegol	DC7DUJW	Rifampicin	Drug Induced Constipation	[4]
Codeine + Naloxegol	DCFBBW7	Codeine	Opioid-Induced Constipation	[5]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7539).
2	ClinicalTrials.gov (NCT02737059) Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects
3	ClinicalTrials.gov (NCT01520896) Study in Healthy Volunteers to Investigate the Effects of Ketoconazole on the Pharmacokinetics of NKTR-118
4	ClinicalTrials.gov (NCT01533870) Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118
5	ClinicalTrials.gov (NCT05770960) Colonic Motor Patterns in Healthy Volunteers