Details of the Drug Combinations

General Information of This Drug (ID: DMLB0EZ)

Drug Name
Tamoxifen   DMLB0EZ
Synonyms
tamoxifen; 10540-29-1; trans-Tamoxifen; Crisafeno; Soltamox; Tamoxifene; Diemon; Tamoxifenum; Tamoxifeno; Tamizam; Istubol; Tamoxen; Citofen; Oncomox; Valodex; Retaxim; Tamoxifene [INN-French]; Tamoxifenum [INN-Latin]; Tamoxifeno [INN-Spanish]; Tamoxifen (Z); Tamoxifen and its salts; Tamoxifen [INN:BAN]; ICI-46474; ICI 47699; TRANS FORM OF TAMOXIFEN; CCRIS 3275; UNII-094ZI81Y45; HSDB 6782; CHEMBL83; EINECS 234-118-0; 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; Citofen; Nourytam; Novaldex; Tamone; Tamoxifeno;Tamoxifenum; Tomaxithen; Gen-Tamoxifen; Istubal (TN); Nolvadex (TN); Nolvadex-D; Novo-Tamoxifen; Pms-Tamoxifen; Tamoplex (TN); Tamoxifen (INN); Tamoxifen (TN); Trans-Tamoxifen; Valodex (TN); TAMOXIFEN (TAMOXIFEN CITRATE (54965-24-1)); Trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene; (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine; (Z)-2-(4-(1,2-diphenylbut-1-enyl)phenoxy)-N,N-dimethylethanamine; (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine (IUPAC); (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE; (Z)-2-[p-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine; 1-p-beta-Dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene; 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene; 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine; 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine; Tamoxifen (Hormonal therapy); [3H]tamoxifen
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Inflammatory breast cancer 2C62 Approved [2]
Invasive ductal breast carcinoma N.A. Approved [2]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

107 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Tamoxifen DCPJU19 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acitretin + Tamoxifen DCIIEW4 Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Armodafinil + Tamoxifen DCJLAHP Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Artemisinin + Tamoxifen DCDNJP7 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Auranofin + Tamoxifen DCRZ4KA Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Bardoxolone methyl + Tamoxifen DCEFH87 Bardoxolone methyl Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Tamoxifen DCNDSRB Bardoxolone methyl Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
BIIB-021 + Tamoxifen DCVXIGA BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
BIO-300 + Tamoxifen DCP71MR BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BMS-754807 + Tamoxifen DCGYVUN BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
BMS-754807 + Tamoxifen DCQQIVU BMS-754807 Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Bortezomib + Tamoxifen DCO8DZL Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
CA4P + Tamoxifen DC8JBGF CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Carglumic acid + Tamoxifen DCYMLLV Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlorzoxazone + Tamoxifen DCB9762 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Clopidogrel + Tamoxifen DCN174U Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
CUDC-101 + Tamoxifen DC2ARVG CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Docetaxel + Tamoxifen DCLQ7XB Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fenoprofen + Tamoxifen DCQ20DE Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fluspirilene + Tamoxifen DCFX3ZH Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Fostamatinib + Tamoxifen DCDVTWK Fostamatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
GDC-0980/RG7422 + Tamoxifen DCFQZYZ GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Hydralazine + Tamoxifen DCZ4RZC Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
IMD-0354 + Tamoxifen DC0XGZR IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
JQ1 + Tamoxifen DCYQ995 JQ1 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Levamisole + Tamoxifen DC0286G Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
LY03004 + Tamoxifen DCJ1P7L LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Mefloquine + Tamoxifen DCM84H1 Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Mefloquine + Tamoxifen DCPMOSD Mefloquine Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Memantine + Tamoxifen DCC58O8 Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
MLN8237 + Tamoxifen DCDYJ8B MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Panobinostat + Tamoxifen DC45TO8 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Parthenolide + Tamoxifen DCK0UD6 Parthenolide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
PD-0325901 + Tamoxifen DC62387 PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
PD-0325901 + Tamoxifen DCOQE2L PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
PF-04691502 + Tamoxifen DCIAG4B PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
PF-04691502 + Tamoxifen DCMDBHU PF-04691502 Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
PF-562271 + Tamoxifen DCOQBIT PF-562271 Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Pramipexole + Tamoxifen DC7LCH4 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Prochlorperazine + Tamoxifen DCS1M17 Prochlorperazine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Prochlorperazine + Tamoxifen DCFEFED Prochlorperazine Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
RTB101 + Tamoxifen DCSUK3R RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
RTB101 + Tamoxifen DCB91XB RTB101 Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
SCH 727965 + Tamoxifen DCIQOY6 SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
SNDX-275 + Tamoxifen DCO8ME4 SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Tamoxifen + Aprepitant DCRZ7K3 Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Bepridil DCJLH7N Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Triiodothyronine DCBBI8U Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Gefitinib DCUA0AX Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Paromomycin DCNIT00 Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Dantrolene DCV27XQ Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Diethylcarbamazine DCNFP13 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Kanamycin DCNYAZ2 Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Citalopram DCRFYQT Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Crotamiton DCHQ82J Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Epinephrine DCGES3D Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + GYKI-52466 DCG5NGA GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Methotrexate DCO2JRJ Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Triapine DCH88ZO Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Everolimus DCIGFMD Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Pepstatin DCH06RJ Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Palonosetron DCFBEGU Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Guanfacine DCLLJ8O Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Doxapram DC7RAQ5 Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Phenprocoumon DC5TV8P Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + ETHISTERONE DC5S3YW ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Armodafinil DCXOAXR Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Tolazoline DC9A1F5 Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + PFK-158 DC3QBUP PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Sulfapyridine DC1UUFH Sulfapyridine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Tolvaptan DCA07FS Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Arfolitixorin DC5U75R Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Eflornithine DCR0ZCH Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + PF-02545920 DCC1KHC PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Trazodone DC1845W Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Etonogestrel DCEPJOX Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Tiagabine DCJ5B78 Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Imatinib DCE1CM9 Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Abacavir DCAL6TJ Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Methylene blue DC4091F Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Clascoterone DCQHKB5 Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Trimethobenzamide DCP3HHG Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Maprotiline DCZ1S7H Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Ethambutol DC724PW Ethambutol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Leflunomide DCP8BVG Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Theophylline DC9GSM8 Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Amiloride DCUY8H6 Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Loperamide DC9J5PE Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Mycophenolic acid DCZFCN9 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Mefloquine DC3Y12V Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Fosfomycin DCKO85P Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Lacosamide DC9V95H Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Vinpocetine DCZSBG1 Vinpocetine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Tamoxifen + Doxorubicin DCQ4SKN Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Testolactone DC04DYR Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Olmesartan medoxomil DCE81T9 Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Estramustine DCW2YEB Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Enoxacin DCGJ7Z3 Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Albendazole DCK67ZD Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Cytarabine DCJBMMH Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tamoxifen + Etomidate DCJNYB3 Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
THAPSIGARGIN + Tamoxifen DC5HNSW THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
THAPSIGARGIN + Tamoxifen DCH3NF2 THAPSIGARGIN Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Trametinib + Tamoxifen DCAEXOU Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Triflupromazine + Tamoxifen DCXMS02 Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tropisetron + Tamoxifen DCFV3GY Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Ym155 + Tamoxifen DCMRB5Y Ym155 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 107 DrugCom(s)
8 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Gefitinib + Tamoxifen DCL2W27 Gefitinib Breast Neoplasms [5]
Goserelin + Tamoxifen DCGEM4X Goserelin Breast Cancer [6]
Goserelin + Tamoxifen DCWUJU0 Goserelin Early-stage Breast Cancer [7]
Tamoxifen + Anastrozole DCAIMGY Anastrozole Bone Density [8]
Tamoxifen + Anastrozole DCUKPRA Anastrozole Quality of Life [9]
Zoledronate + Tamoxifen DCR04IN Zoledronate Breast Cancer [10]
Letrozole + Tamoxifen DC9ZSUV Letrozole Breast Cancer [11]
LY2835219 + Tamoxifen DCAF96A LY2835219 Male Breast Cancer [12]
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⏷ Show the Full List of 8 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1016).
2 Tamoxifen FDA Label
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5 ClinicalTrials.gov (NCT00229697) Phase II Metastatic ER+/PgR+ Nolvadex +/- Iressa Study
6 ClinicalTrials.gov (NCT00605267) Arimidex/Tamoxifen Neo Adjuvant Study in Premenopausal Patients With Breast Cancer Under Anti Hormonal Treatment
7 ClinicalTrials.gov (NCT00309478) Randomized Study Comparing CMF and Goserelin + Tamoxifen in Premenopausal Receptor-positive Patients
8 ClinicalTrials.gov (NCT00784940) ATAC - Bone Density Sub-Protocol
9 ClinicalTrials.gov (NCT00784680) ATAC - Quality of Life Sub-Protocol
10 ClinicalTrials.gov (NCT00295646) Tamoxifen Versus Anastrozole, Alone or in Combination With Zoledronic Acid
11 ClinicalTrials.gov (NCT02764541) Palbociclib and Endocrine Therapy for LObular Breast Cancer Preoperative Study (PELOPS)
12 ClinicalTrials.gov (NCT05501704) ETHAN - ET for Male BC