Details of the Drug Combinations

General Information of This Drug (ID: DMLBVKQ)

Drug Name
Entacapone   DMLBVKQ
Synonyms
Comtan; Comtess; Entacapona; Entacaponum; Novartis brand of entacapone; Orion brand of entacapone; KB475572; OR 611; COM-998; Comtan (TN); Entacapona [INN-Spanish]; Entacapone [USAN:INN]; Entacaponum [INN-Latin]; OR-611; Stalevo (TN); Entacapone (JAN/USAN/INN); N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl) acrylamide; (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide; (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; (E)-2-cyano-3-(3,4-dihydroxy-5-nitro-phenyl)-N,N-diethyl-prop-2-enamide; (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide; (E)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide; 2-Cyano-N,N-diethyl-3-(3,4-dihydroxy-5-nitrophenyl)propenamide
Indication
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [1]
Therapeutic Class
Antiparkinson Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

55 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Entacapone DCKBJXF Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amiloride + Entacapone DC7FOTX Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Entacapone DCGZ8SU Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Benserazide + Entacapone DCE3BPZ Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Entacapone DCB288A BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bosentan + Entacapone DCD4AFD Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Entacapone DCMWQLA Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cinacalcet + Entacapone DCWO6RH Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + Entacapone DCR0RU9 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Eflornithine + Entacapone DCT3P30 Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Emetine + Entacapone DC1468I Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Bepridil DCHJW20 Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Gefitinib DCEUN8R Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Dantrolene DC7A200 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Epinephrine DCDPN1R Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Vinblastine DC8SXAF Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Everolimus DCYTGB8 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Chlorzoxazone DCXQWXG Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Memantine DCZRNKN Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Phenprocoumon DCWI33G Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Dichlorphenamide DCWPCUX Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Tolazoline DCBP77D Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Isoproterenol DC72S5Q Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Trifluoperazine DC1I6NV Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Abacavir DCRIFBN Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Methylene blue DCS7RD0 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Artemisinin DCK80N8 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Olanzapine DCV4QHX Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Trimethobenzamide DC22YQL Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Enalaprilat DCWA453 Enalaprilat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Maprotiline DCGE6R2 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Eptifibatide DC6TA96 Eptifibatide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Acetohexamide DCTUK39 Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Brincidofovir DCXCBK4 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Sorafenib DCK5G5O Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Hyodeoxycholic acid DCCTWCS Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Asenapine DC553E1 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Mycophenolic acid DC4CZVY Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Mefloquine DCT9PCF Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Nitisinone DC9VXAJ Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Auranofin DCN0A6C Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Cevimeline DCWQRTS Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Cerivastatin DC4DUVY Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Aciclovir DCH815B Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Tetracycline DCDG7G7 Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Cytarabine DCBP9G8 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + L-165041 DC8VDPL L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fluspirilene + Entacapone DCJRM94 Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Entacapone DCFY60I Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Loperamide + Entacapone DC1CKBJ Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Entacapone DC0ZTNR Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pamidronate + Entacapone DC3NL2D Pamidronate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Entacapone DCO9SK3 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tindamax + Entacapone DCKJT06 Tindamax Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Entacapone DC3HAPB Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 55 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Carbidopa + Entacapone DCCQ9YE Carbidopa Restless legs syndrome; Parkinson disease [3]
Entacapone + Methamphetamine DC7PZ66 Methamphetamine Methamphetamine Dependence [4]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6647).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 FDA Drug Development and Drug Interactions
4 ClinicalTrials.gov (NCT02058966) Pilot Study of Entacapone for Methamphetamine Abuse