Details of the Drug Combinations

General Information of This Drug (ID: DMLMNFX)

Drug Name

Omaveloxolone DMLMNFX

Synonyms

RJCWBNBKOKFWNY-HGNIWHNWSA-N; N-((4aR,6aR,6bS,12aS,14aR,14bR)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide; 1474034-05-3; AKOS030526563

Indication

Disease Entry	ICD 11	Status	REF
Friedreich's ataxia	8A03.10	Approved	[1]
Melanoma	2C30	Phase 1/2	[2]
Psychiatric disorder	6E8Z	Clinical trial	[3]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Omaveloxolone + Idarubicin	DCHQ57O	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]
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2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Gemcitabine + Omaveloxolone	DCD6MTR	Gemcitabine	Pancreatic Neoplasms	[5]
Omaveloxolone + Moxifloxacin	DC16REB	Moxifloxacin	Health Adult Subjects	[6]
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References

1	FDA Approved Drug Products from FDA Official Website. 2023. Application Number: 216718.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin. Arch Dermatol Res. 2014 Jul;306(5):447-54.
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT00529113) Study With Gemcitabine and RTA 402 for Patients With Unresectable Pancreatic Cancer
6	ClinicalTrials.gov (NCT05927649) A TQTc Study for Omaveloxolone