Details of the Drug Combinations

General Information of This Drug (ID: DMLPEZS)

Drug Name

Venglustat DMLPEZS

Synonyms

Ibiglustat; 1401090-53-6; UNII-BLP1XA3FZA; BLP1XA3FZA; (S)-Quinuclidin-3-yl (2-(2-(4-fluorophenyl)thiazol-4-yl)propan-2-yl)carbamate; Ibiglustat [INN]; SCHEMBL12615329; YFHRCLAKZBDRHN-MRXNPFEDSA-N; Ibiglustat(Genz-682452 pound(c); GZ-452; SAR402671; ZINC202143443; AKOS027337125; CS-6512; Carbamic acid, N-(1-(2-(4-fluorophenyl)-4-thiazolyl)-1-methylethyl)-, (3S)-1-azabicyclo(2.2.2)oct-3-yl ester; (3S)-1-Azabicyclo(2.2.2)octan-3-yl N-(2-(2-(4-fluorophenyl)-1,3-thiazol-4-yl)propan-2-yl)carbamate; GZ4026

Indication

Disease Entry	ICD 11	Status	REF
Fabry disease	5C56.01	Phase 2	[1]
Parkinson disease	8A00.0	Phase 2	[2]
Gaucher disease	5C56.0Y	Phase 1	[3]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

18 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AG-881 + Venglustat	DC2L9IN	AG-881	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
PFI-3 + Venglustat	DC4AAVU	PFI-3	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Tosyl-l-arginine methyl ester + Venglustat	DCQYJNO	Tosyl-l-arginine methyl ester	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Ribavirin-TP	DC1VU1L	Ribavirin-TP	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + PD-0325901	DCM5LVP	PD-0325901	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + MK-1775	DCA9Q2J	MK-1775	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + JQ1	DCMZKTD	JQ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Panobinostat	DCS8CZS	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Everolimus	DC92B6A	Everolimus	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Evacetrapib	DCV7D54	Evacetrapib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Marizomib	DCEZZ29	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + ONC201	DC1IM8K	ONC201	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + LEE011	DCFJMGM	LEE011	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + BMS-754807	DCBZ3WS	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Teriflunomide	DCKC98B	Teriflunomide	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + PF-562271	DCCPRQN	PF-562271	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + THZ1	DCRLSFX	THZ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
Venglustat + Ruxolitinib	DCVIEW8	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[5]
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⏷ Show the Full List of 18 DrugCom(s)

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036945)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.