Details of the Drug Combinations

General Information of This Drug (ID: DMMFWOJ)

Drug Name

Probenecid DMMFWOJ

Synonyms

Apurina; Bencid; Benecid; Benemid; Benemide; Benuryl; Panuric; Parabenem; Probalan; Probampacin; Probecid; Proben; Probenecida; Probenecide; Probenecidum; Probenemid; Probenicid; Probenid; Probexin; Prolongine; Robenecid; Sulprin; Tubophan; Uricosid; Urocid; Biokanol Brand of Probenecid; ICN Brand of Probenecid; IDIS Brand of Probenecid; Major Brand of Probenecid; Martec Brand of Probenecid; Merck Brand of Probenecid; Ophthalmic Brand of Probenecid; Parmed Brand of Probenecid; Probenecid Major Brand; Probenecid Martec Brand; Probenecid Parmed Brand; Probenecid Weimer; Probenecid Zenith Brand; Probenecid acid; Synergid R; Valdecasas Brand of Probenecid; Zenith Brand of Probenecid; Benemid (TN); Benuryl (TN); Col-BENEMID; ColBenemid (co mponent of); ColBenemid (component of); P-[Dipropylsulfamoyl]benzoic acid; Polycillin-BRB; Pro-Cid; Probenecida [INN-Spanish]; Probenecide [INN-French]; Probenecidum [INN-Latin]; P-(Dipropylsulfamoyl)benzoic acid; P-(Dipropylsulfamyl)benzoic acid; Polycillin-PRB (component of); Probenecid [INN:BAN:JAN]; Probenecid (JP15/USP/INN); 4-((Dipropylamino)sulfonyl)benzoic acid;4-(Di-n-propylsulfamoyl)benzoesaeure; 4-(Dipropylsulfamoyl)benzoic acid; 4-(N,N-Dipropylsulfamoyl)benzoesaeure; 4-[(dipropylamino)sulfonyl]benzoic acid

Indication

Disease Entry	ICD 11	Status	REF
Acute gonococcal cervicitis	N.A.	Approved	[1]
Gout	FA25	Approved	[2]
Hyperuricaemia	5C55.Y	Approved	[2]
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Therapeutic Class

Uricosuric Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

107 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amodiaquine + Probenecid	DCDYF4P	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aprepitant + Probenecid	DCLO32N	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Arfolitixorin + Probenecid	DCU21JE	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Armodafinil + Probenecid	DCP3LDK	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Probenecid	DCCC89Z	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Auranofin + Probenecid	DCJZGSV	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Benserazide + Probenecid	DCJMSZ5	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BHV-0223 + Probenecid	DC5NQED	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Probenecid	DC87PC2	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Probenecid	DCDB55G	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Busulfan + Probenecid	DC0OE6Q	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Probenecid	DC77QJJ	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cilostazol + Probenecid	DCJPQGX	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cisatracurium + Probenecid	DCZ05NA	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Probenecid	DC0LU47	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Probenecid	DCD9X0V	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Probenecid	DC0B9A1	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Desoxycorticosterone pivalate + Probenecid	DCJDXLO	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dexmedetomidine + Probenecid	DCSWNOP	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diazoxide + Probenecid	DC5LU8O	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dichlorphenamide + Probenecid	DCLRK51	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Probenecid	DCCD5T7	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Enalaprilat + Probenecid	DCYOFOC	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Probenecid	DCNHQRO	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ethambutol + Probenecid	DCFD6WL	Ethambutol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ginsenoside Rb1 + Probenecid	DC5YOFB	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hydralazine + Probenecid	DCNSS0E	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Probenecid	DCLD3HX	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Probenecid	DC7J2KK	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
JZL195 + Probenecid	DCH55Z3	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Kanamycin + Probenecid	DCR0UUD	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
L-165041 + Probenecid	DCC89TS	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Probenecid	DCYSGQU	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Leflunomide + Probenecid	DCMGGGI	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lumefantrine + Probenecid	DCGWKKM	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Probenecid	DCP7R65	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Probenecid	DCR7X1M	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Memantine + Probenecid	DCYONPQ	Memantine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methocarbamol + Probenecid	DCS4LTW	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Moricizine + Probenecid	DCLMLQY	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Probenecid	DC9XCJX	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Naringenin + Probenecid	DCFS5K5	Naringenin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olanzapine + Probenecid	DCZWEU0	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pamidronate + Probenecid	DCSKRA1	Pamidronate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pepstatin + Probenecid	DCIQ53J	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PF-02545920 + Probenecid	DC20FOQ	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PHA-739358 + Probenecid	DCV2AHL	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phensuximide + Probenecid	DCOB4BR	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Probenecid	DC3G7QO	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Probenecid	DCKS00M	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pramipexole + Probenecid	DCUC184	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Lefaxin	DCROF6W	Lefaxin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Mebutamate	DCAYY61	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Primidone	DC26VNY	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Gefitinib	DCOBFD6	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Epinephrine	DCITGRE	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Trioxsalen	DCX4VG3	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Methotrexate	DC7D973	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Mephenytoin	DCB2DIQ	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Pazopanib HCl	DCLVKQO	Pazopanib HCl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Triapine	DCIB796	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Methylergonovine	DCZO3EF	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Palonosetron	DCG2L50	Palonosetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Metyrosine	DCIUWOL	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Cinacalcet	DC0NAPU	Cinacalcet	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Chlorzoxazone	DCY0ZS3	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + K-134	DCJAANE	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Metformin	DCLUJ2O	Metformin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Docetaxel	DCZ0Q0V	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Methoxsalen	DCMSN2P	Methoxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + WAY-100635	DC5AY8V	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Ciprofibrate	DCH0B6F	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Diphenidol	DCU5YYQ	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Sulfapyridine	DCRSK86	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Triflupromazine	DCCCFSL	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Niclosamide	DCBC1UO	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + PF-02545920	DCFWXQ9	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Tiagabine	DCBMJJQ	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Ibutilide	DC9E2SG	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Diazoxide	DCJMKH8	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Methylene blue	DCSQ59J	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Topotecan	DCMBH8X	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Trimethobenzamide	DC9IWTO	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Acetohexamide	DCQJFCX	Acetohexamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Theophylline	DCQ40G4	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Chlorambucil	DCV6ZFQ	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Bumetanide	DCL3EY3	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Brincidofovir	DCCDKYU	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Asenapine	DCZ528W	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Maraviroc	DCLYCZA	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Endoxifen	DCVE0XF	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Mycophenolic acid	DCHKZ1O	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Nabilone	DC6HUW5	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Cerivastatin	DC8MWMI	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Albendazole	DC5Y46S	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Probenecid + Tetracycline	DCGSIQ6	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Procarbazine + Probenecid	DCHEEWJ	Procarbazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Probenecid	DCMT5Q7	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sulfapyridine + Probenecid	DCCQPIU	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sumatriptan + Probenecid	DCTDVEH	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trazodone + Probenecid	DCMV1JH	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triamterene + Probenecid	DCE7KS7	Triamterene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Probenecid	DCENJT6	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triflupromazine + Probenecid	DCOYTTQ	Triflupromazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trimethobenzamide + Probenecid	DCV2X7U	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Probenecid	DCVIZOY	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Zileuton + Probenecid	DCI7LTA	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 107 DrugCom(s)

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AKB-6548 + Probenecid	DC5IVOK	AKB-6548	Drug Interaction Potentiation	[5]
Canagliflozin + Probenecid	DCK7KCA	Canagliflozin	Type 2 Diabetes Mellitus	[6]
Cidofovir + Probenecid	DCAPN22	Cidofovir	Blood And Marrow Transplantation	[7]
Oseltamivir + Probenecid	DCBUTRC	Oseltamivir	Influenza	[8]
Probenecid + Furosemide	DCLUTXO	Furosemide	Interaction	[9]
Probenecid + AV-101	DCTH44N	AV-101	Drug Drug Interaction	[10]
Semaglutide + Probenecid	DCJEIB5	Semaglutide	Diabetes	[11]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	Probenecid FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4357).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT03801746) Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin
6	ClinicalTrials.gov (NCT03296800) Study to Evaluate Effects of Probenecid, Rifampin and Verapamil on Bexagliflozin in Healthy Subjects
7	ClinicalTrials.gov (NCT01816646) Intravesical Cidofovir for Hemorrhagic Cystitis
8	ClinicalTrials.gov (NCT00304434) Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies.
9	ClinicalTrials.gov (NCT05365451) Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters
10	ClinicalTrials.gov (NCT05280054) AV-101 Alone and in Combination With Probenecid in Healthy Subjects
11	ClinicalTrials.gov (NCT03466567) A Trial Investigating the Effect of Probenecid and Ciclosporin on the Concentrations of SNAC in Healthy Subjects