Details of the Drug Combinations

General Information of This Drug (ID: DMN5T2A)

Drug Name
Ciclopirox   DMN5T2A
Synonyms
Ciclopiroxum; Cyclopirox; Cyclopyroxolamine; Loprox; Penlac; Stieprox; Terit; Ciclopirox Olamin; Ciclopirox gel; Loprox Gel; Loprox Shampoo; Loprox cream; Penlac nail lacquer; HOE 296b; Batrafen (TN); Ciclopirox-Olamin; Ciclopiroxum [INN-Latin]; Dafnegin-CSC; HOE-296; HOE-296b; Loprox (TN); Penlac (TN); Stieprox (TN); Ciclopirox (USP/INN); Ciclopirox [USAN:BAN:INN]; (6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone); 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone; 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone; 6-Cyclohexyl-1-hydroxy-4-methyl-2-(1H)-pyridone; 6-cyclohexyl-1-hydroxy-4-methyl-2(1 H)-pyridinone; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one; 6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one
Indication
Disease Entry ICD 11 Status REF
Cutaneous candidiasis 1F23.14 Approved [1]
Fungal infection 1F29-1F2F Approved [2]
Mycoses 1F2Z Approved [1]
Onychomycosis EE12.1 Approved [1]
Pityriasis simplex N.A. Approved [1]
Tinea corporis 1F28.Y Approved [1]
Tinea cruris 1F28.3 Approved [1]
Tinea versicolor 1F2D.0 Approved [1]
Tinea pedis 1F28.2 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antifungal Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

23 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + Ciclopirox DCF1VBF ABT-263 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
AS602868 + Ciclopirox DC5VY16 AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
BIIB-021 + Ciclopirox DCIZZ9R BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
BMS-754807 + Ciclopirox DCI6I60 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
CA4P + Ciclopirox DCRJAVG CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Cantharidin + Ciclopirox DCH3KF4 Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Carfilzomib + Ciclopirox DC3DDCR Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Ciclopirox + Panobinostat DC7AJBT Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [4]
CUDC-101 + Ciclopirox DC7U616 CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Dasatinib + Ciclopirox DCNQHSF Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Fostamatinib + Ciclopirox DCC24WX Fostamatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
GDC-0980/RG7422 + Ciclopirox DCS5CFG GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
IMD-0354 + Ciclopirox DCU24NC IMD-0354 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Mifepristone + Ciclopirox DC0854Y Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
NVP-AUY922 + Ciclopirox DCGNHKJ NVP-AUY922 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Palbociclib + Ciclopirox DC72GQL Palbociclib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Parthenolide + Ciclopirox DCKFK9F Parthenolide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
PD-0325901 + Ciclopirox DCURBNN PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
PF-04691502 + Ciclopirox DCPJDTH PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Prochlorperazine + Ciclopirox DCJXF5R Prochlorperazine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
RTB101 + Ciclopirox DC5B5FF RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
THAPSIGARGIN + Ciclopirox DCPJ8TQ THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [4]
Trametinib + Ciclopirox DC0G7ZZ Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 23 DrugCom(s)

References

1 Ciclopirox FDA Label
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 076435.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.