Details of the Drug Combinations

General Information of This Drug (ID: DMN6DXL)

• Drug Name: Risperidone (DMN6DXL)
• Synonyms: Belivon; Risperdal; Risperdone; Risperidal; Risperidona; Risperidonum; Risperin; Rispolept; Rispolin; Sequinan; Risperdal Consta; Risperidona [Spanish]; Risperidonum [Latin]; R 62 766; R 64766; R64766; Consta, Risperdal; KS-1106; R 64,766; R-118; R-64766; R64,766; Risperdal (TN); Risperdal M-Tab; Risperidal M-Tab; Risperidone (RIS); Risperidone, placebo; R 64 766, Risperdal, Risperidone; R-64,766; R-64-766; Risperidone [USAN:BAN:INN]; Risperidone (JAN/USAN/INN); 3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino)ethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido(1,2-a)pyrimidin-4-one; 3-[2-[-4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido [1,2-a] pyrimidin-4-one; 3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperi-dino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]-pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one; 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-Fluoro-benzo[d]isoxazol-3-yl)-piperidin-1-yl]-ethyl}-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one; 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one

Indication

Bipolar I disorder; ICD 11: N.A.; Status: Approved [1]; Schizoaffective disorder; ICD 11: 6A21; Status: Approved [1]; Schizophrenia; ICD 11: 6A20; Status: Approved [2]; Autism; ICD 11: N.A.; Status: Investigative [1]

• Therapeutic Class: Antipsychotic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Citalopram + Risperidone	DCN9DPZ	Citalopram	Schizophrenia	[3]
Risperidone + Tropisetron	DCI68V9	Tropisetron	Smoking Cessation	[4]
Risperidone + Oxycodone	DCD1JKC	Oxycodone	Addiction	[5]
Risperidone + Olanzapine	DC6PIXN	Olanzapine	Schizophrenia	[6]
Dextroamphetamine + Risperidone	DC23QN8	Dextroamphetamine	Attention Deficit Disorder With Hyperactivity	[7]
Quetiapine + Risperidone	DCC5U45	Quetiapine	Bipolar Disorder	[8]
Quetiapine + Risperidone	DCCGTQH	Quetiapine	Schizophrenia	[9]
Risperidone + Modafinil	DCD05ZL	Modafinil	Schizophrenia	[10]
Sertindole + Risperidone	DCTBT72	Sertindole	Schizophrenia	[11]
Trazodone + Risperidone	DCOIUVL	Trazodone	Delirium	[12]

References

• [1] Risperidone FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 96).
• [3] ClinicalTrials.gov (NCT00893256) Effect of Add-on Citalopram to Risperidone on Negative Symptoms in Schizophrenia
• [4] ClinicalTrials.gov (NCT00435370) Effectiveness of Tropisetron Plus Risperidone for Improving Cognitive and Perceptual Disturbances in Schizophrenia
• [5] ClinicalTrials.gov (NCT04587115) Reducing the Abuse Liability of Prescription Opioids
• [6] ClinicalTrials.gov (NCT02717195) Effect of Lu AF35700 in Patients With Treatment-resistant Schizophrenia
• [7] ClinicalTrials.gov (NCT00794625) Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study)
• [8] ClinicalTrials.gov (NCT02562287) Clozapine Versus Other Atypical Antipsychotics for Bipolar Disorder
• [9] ClinicalTrials.gov (NCT00423878) Comparison of Antipsychotics for Metabolic Problems in Schizophrenia or Schizoaffective Disorder
• [10] ClinicalTrials.gov (NCT01913327) Antipsychotic Effects on Brain Function in Schizophrenia
• [11] ClinicalTrials.gov (NCT02021201) The Effect of Sertindole and Risperidone on Endophenotypic Markers of Schizophrenia
• [12] ClinicalTrials.gov (NCT02118688) Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium