Details of the Drug Combinations

General Information of This Drug (ID: DMN9CWF)

• Drug Name: Salbutamol (DMN9CWF)
• Synonyms: Aerolin; Airomir; Almotex; Anebron; Asmadil; Asmanil; Asmasal; Asmatol; Asmaven; Asmidon; Asmol; Asthalin; Asthavent; Broncovaleas; Bronter; Bugonol; Bumol; Butamol; Butohaler; Butotal; Butovent; Buventol; Cetsim; Cobutolin; Dilatamol; Ecovent; Farcolin; Gerivent; Grafalin; Libretin; Medolin; Mozal; Novosalmol; Parasma; Pneumolat; Proventil; Respax; Respolin; Rotahaler; Sabutal; Sabutamol; Salamol; Salbetol; Salbron; Salbuhexal; Salbulin; Salbupur; Salbusian; Salbutalan; Salbutamolum; Salbutan; Salbutard; Salbutine; Salbutol; Salbuven; Salbuvent; Sallbupp; Salmaplon; Salomol; Salvent; Saventol; Servitamol; Solbutamol; Spreor; Sultanol; Suprasma; Suxar; Theosal; Tobybron; Vencronyl; Ventamol; Ventilan; Ventiloboi; Ventodisks; Ventoline; Volma; Volmax; Zaperin; Albuterol Sulphate; Albuterol [USAN]; Albuterol hemisulfate; Proventil HFA; Proventil Inhaler; Salbutamol Sulphate; Salbutamol sulfate; Sultanol N; Ventalin inhaler; Ventolin Inhaler; Ventolin Rotacaps; Volare albuterol HFA; AH 3365; S 8260; Aerolin (TN); Albuterol (USP); Alti-Salbutamol; Arubendol-Salbutamol; Asmol Uni-Dose; Asthalin (TN); Broncho-Spray; Buto-Asma; Dl-Albuterol; Dl-Salbutamol; ProAi (TN); Proventil (TN); Racemic-Salbutamol; Salbu-BASF; Salbu-Fatol; Salbutamolum [INN-Latin]; Ventolin (TN); Volare easi-breathe; R,S-Albuterol; Alpha-[(t-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha-diol; Alpha-[(tert-Butylamino)methyl]-4-hydroxy-m-xylene-alpha,alpha'-diol; DL-N-tert-Butyl-2-(4-hydroxy-3-hydroxymethylphenyl)-2-hydroxyethylamine; Alpha'-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol; Alpha(sup 1)-((tert-Butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha'-diol; (alpha1-((tert-butylamino)methyl)-4-hydroxy-m-xylene-alpha,alpha-diol); 1-(tert-Butylaminomethyl)-4-hydroxy-m-xylene-alpha1,alpha3-diol; 2-(tert-Butylamino)-1-(4-hydroxy-3-hydroxymethylphenyl)ethanol; 2-t-Butylamino-1-(4-hydroxy-3-hydroxy-3-hydroxymethyl)phenylethanol; 4-Hydroxy-3-hydroxymethyl-alpha-((tert-butylamino)methyl)benzyl alcohol; 4-[2-(tert-Butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol; 4-{2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol

Indication

Acute asthma; ICD 11: CA23; Status: Approved [1]; Adult respiratory distress syndrome; ICD 11: CB00; Status: Approved [2]; Severe asthma; ICD 11: CA23; Status: Approved [3]

• Therapeutic Class: Bronchodilator Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

13 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bisoprolol + Salbutamol	DCPE2SO	Bisoprolol	Primary Hypertension	[4]
Glatiramer acetate + Salbutamol	DCFNG7Z	Glatiramer acetate	Autoimmune Diseases	[5]
Glycopyrrolate + Salbutamol	DCWDUM9	Glycopyrrolate	Chronic Obstructive Pulmonary Disease	[6]
Ipratropium + Salbutamol	DCJNGYI	Ipratropium	Asthma	[7]
Levalbuterol + Salbutamol	DC74AVT	Levalbuterol	COPD	[8]
Propranolol + Salbutamol	DC448PB	Propranolol	Pulmonary Disease, Chronic Obstructive	[9]
Salbutamol + Roflumilast	DCKY9IF	Roflumilast	COPD	[10]
Salbutamol + Acetylcysteine	DCSZ4QX	Acetylcysteine	Chronic Obstructive Pulmonary Disease	[11]
Salbutamol + Nitroglycerin	DCWGMBD	Nitroglycerin	Primary Hypertension	[4]
Tiotropium + Salbutamol	DCD2NNT	Tiotropium	Chronic Obstructive Pulmonary Disease	[6]
Glycopyrrolate + Salbutamol	DCJWETV	Glycopyrrolate	Asthma	[12]
Fluticasone + Salbutamol	DCLUY6J	Fluticasone	Asthma	[13]
Ipratropium + Salbutamol	DCO576V	Ipratropium	Asthma	[14]

1 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ipratropium + Salbutamol	DCPAUFA	Ipratropium	Asthma	[15]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 558).
• [2] Effects of nebulized salbutamol on respiratory mechanics in adult respiratory distress syndrome. Intensive Care Med. 1997 Jan;23(1):58-64.
• [3] Salbutamol and ipratropium by inhaler is superior to nebulizer in children with severe acute asthma exacerbation: Randomized clinical trial. Pediatr Pulmonol. 2019 Apr;54(4):372-377.
• [4] ClinicalTrials.gov (NCT01742702) HaemoDYNAMICs in Primary and Secondary Hypertension
• [5] ClinicalTrials.gov (NCT00039988) Treatment of Multiple Sclerosis With Copaxone and Albuterol
• [6] ClinicalTrials.gov (NCT01120691) Effect of QVA149 Versus NVA237 and Tiotropium on Chronic Obstructive Pulmonary Disorder (COPD) Exacerbations
• [7] ClinicalTrials.gov (NCT05550402) Role of Parasympathetic Activity in Mild to Severe Asthma With Fixed Airway Obstruction (PARASMA Study)
• [8] ClinicalTrials.gov (NCT01151579) Effect of Nebulized Bronchodilators on Heart Rate
• [9] ClinicalTrials.gov (NCT00549120) Optimising the Propranolol Block Model
• [10] ClinicalTrials.gov (NCT01313494) A Chronic Obstructive Pulmonary Disease (COPD) Trial Investigating Roflumilast on Safety and Effectiveness in China, Hong Kong and Singapore:
• [11] ClinicalTrials.gov (NCT02818270) Evaluation of Aerosolized Drugs Deposition During Mechanical Ventilation
• [12] ClinicalTrials.gov (NCT02127697) Study of Efficacy and Safety of NVA237 in Patients With Poorly Controlled Asthma
• [13] ClinicalTrials.gov (NCT03363191) The Efficacy of Fluticasone Furoate/Vilanterol Versus (vs) Fluticasone Furoate on Asthma
• [14] ClinicalTrials.gov (NCT02235428) Study to Assess the Efficacy of Ipratropium Bromide Associated With High Dose Salbutamol by Repeated Nebulisation Versus Repeat Nebulisation of Salbutamol Alone, in Acute Asthmatic Attacks in Young Children
• [15] UniProt: the universal protein knowledgebase. Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169. (ID: O95477)