Details of the Drug Combinations

General Information of This Drug (ID: DMODA2X)

Drug Name
Bardoxolone methyl   DMODA2X
Synonyms BARD; WPTTVJLTNAWYAO-OYWPANLISA-N; 218600-53-4
Indication
Disease Entry ICD 11 Status REF
Mixed connective tissue disease 4A43.3 Phase 3 [1]
Pulmonary arterial hypertension BB01.0 Phase 2 [2]
Pulmonary hypertension BB01 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

78 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + Bardoxolone methyl DC7ES4T (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [3]
ABT-263 + Bardoxolone methyl DCYGO5P ABT-263 Ewing sarcoma (Cell Line: TC-71) [4]
AS602868 + Bardoxolone methyl DCIALJR AS602868 Glioblastoma (Cell Line: JHH-136) [3]
AT13387 + Bardoxolone methyl DCC3EWI AT13387 Ewing sarcoma (Cell Line: TC-71) [3]
AXL-1717 + Bardoxolone methyl DCVJNA8 AXL-1717 Ewing sarcoma (Cell Line: TC-71) [3]
AXL-1717 + Bardoxolone methyl DCQK90V AXL-1717 Hodgkin lymphoma (Cell Line: U-HO1) [4]
Bardoxolone methyl + Ruxolitinib DC3XQPZ Ruxolitinib T-cell leukemia/lymphoma (Cell Line: ED-40515) [3]
Bardoxolone methyl + Ombrabulin DCDKWHB Ombrabulin Hodgkin lymphoma (Cell Line: L-1236) [3]
Bardoxolone methyl + JQ1 DC6Q2IK JQ1 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Prochlorperazine DCTZCNH Prochlorperazine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Prochlorperazine DC1EFIH Prochlorperazine Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Bardoxolone methyl + Panobinostat DCY0HUS Panobinostat Hodgkin lymphoma (Cell Line: L-1236) [3]
Bardoxolone methyl + Ym155 DCTJQCS Ym155 Hodgkin lymphoma (Cell Line: L-1236) [3]
Bardoxolone methyl + Ixazomib DCIS62O Ixazomib Glioblastoma (Cell Line: JHH-136) [3]
Bardoxolone methyl + Fomepizole DCCITB8 Fomepizole Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Fomepizole DCLYL71 Fomepizole Hodgkin lymphoma (Cell Line: U-HO1) [3]
Bardoxolone methyl + Fomepizole DCP9IIL Fomepizole Hodgkin lymphoma (Cell Line: L-1236) [3]
Bardoxolone methyl + AZD8055 DC0ZXXA AZD8055 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Formononetin DCV35GB Formononetin Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Formononetin DC4MDFI Formononetin Hodgkin lymphoma (Cell Line: U-HO1) [3]
Bardoxolone methyl + GDC-0084 DC33TFM GDC-0084 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + TAK-733 DC1PP2P TAK-733 Glioblastoma (Cell Line: JHH-136) [3]
Bardoxolone methyl + Daporinad DCP3NZV Daporinad Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + THAPSIGARGIN DCRYJ82 THAPSIGARGIN Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
Bardoxolone methyl + THAPSIGARGIN DCTJE1Y THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + THAPSIGARGIN DC6U8OG THAPSIGARGIN Ewing sarcoma (Cell Line: EW-8) [3]
Bardoxolone methyl + THAPSIGARGIN DCHKUJG THAPSIGARGIN Hodgkin lymphoma (Cell Line: U-HO1) [3]
Bardoxolone methyl + GDC-0980/RG7422 DC6SO7B GDC-0980/RG7422 Glioblastoma (Cell Line: JHH-136) [3]
Bardoxolone methyl + PHA-739358 DCGLPXS PHA-739358 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Mifepristone DCGXM5H Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Mitomycin DCQVDPS Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
Bardoxolone methyl + Pelitinib DCQBWKY Pelitinib Glioblastoma (Cell Line: JHH-136) [3]
Bardoxolone methyl + AS602868 DCFIJLO AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Tamoxifen DCEFH87 Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Tamoxifen DCNDSRB Tamoxifen Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Bardoxolone methyl + Idarubicin DCSIUXA Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Bardoxolone methyl + GSK2126458 DC0YNDH GSK2126458 Glioblastoma (Cell Line: JHH-136) [3]
Bardoxolone methyl + ABT-263 DC7EMQS ABT-263 Hodgkin lymphoma (Cell Line: L-1236) [3]
Bardoxolone methyl + Mebendazole DC8B6CJ Mebendazole Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Mebendazole DCEU165 Mebendazole Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Bardoxolone methyl + Ispinesib DC701U9 Ispinesib Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Obatoclax DCZZEUA Obatoclax Glioblastoma (Cell Line: JHH-136) [3]
Bardoxolone methyl + Chloroquine DCHZU3Z Chloroquine Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Bardoxolone methyl + PF-562271 DCGOS5F PF-562271 Hodgkin lymphoma (Cell Line: U-HO1) [3]
Bardoxolone methyl + Romidepsin DCOC2X4 Romidepsin Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + NVP-AUY922 DCT6CCI NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [3]
Bardoxolone methyl + Auranofin DCH5DPN Auranofin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Bardoxolone methyl + Auranofin DCXQRXB Auranofin Primitive neuroectodermal tumor (Cell Line: TC-32) [3]
Bardoxolone methyl + Ibrutinib DCUZKN5 Ibrutinib Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
Bardoxolone methyl + LY2874455 DC1AFS0 LY2874455 Ewing sarcoma (Cell Line: TC-71) [3]
BN-2629 + Bardoxolone methyl DCGJ498 BN-2629 Ewing sarcoma (Cell Line: TC-71) [3]
BN-2629 + Bardoxolone methyl DC6A841 BN-2629 Hodgkin lymphoma (Cell Line: U-HO1) [4]
CA4P + Bardoxolone methyl DC3XF8I CA4P Glioblastoma (Cell Line: JHH-136) [3]
Carfilzomib + Bardoxolone methyl DC2EBWE Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Cycloheximide + Bardoxolone methyl DCIADTJ Cycloheximide Ewing sarcoma (Cell Line: TC-71) [3]
Cycloheximide + Bardoxolone methyl DCHNNT1 Cycloheximide Hodgkin lymphoma (Cell Line: U-HO1) [4]
Efaproxyn + Bardoxolone methyl DCUK7WN Efaproxyn Ewing sarcoma (Cell Line: TC-71) [3]
Everolimus + Bardoxolone methyl DCHHXPX Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
Fenretinide + Bardoxolone methyl DCYC3V4 Fenretinide Glioblastoma (Cell Line: JHH-136) [3]
GDC-0084 + Bardoxolone methyl DCYNRXX GDC-0084 Ewing sarcoma (Cell Line: TC-71) [3]
KN-62 + Bardoxolone methyl DCWZKBH KN-62 DD2 (Cell Line: DD2) [3]
Lestaurtinib + Bardoxolone methyl DCMOLMV Lestaurtinib Ewing sarcoma (Cell Line: TC-71) [3]
LY2523355 + Bardoxolone methyl DCH5XRP LY2523355 Ewing sarcoma (Cell Line: TC-71) [3]
Mebendazole + Bardoxolone methyl DC32H0U Mebendazole Glioblastoma (Cell Line: JHH-136) [3]
Mitomycin + Bardoxolone methyl DCOY1NR Mitomycin Ewing sarcoma (Cell Line: TC-71) [3]
Mitomycin + Bardoxolone methyl DCPDGVH Mitomycin Hodgkin lymphoma (Cell Line: U-HO1) [4]
MK-1775 + Bardoxolone methyl DC2F2UE MK-1775 Hodgkin lymphoma (Cell Line: U-HO1) [3]
MK-2206 + Bardoxolone methyl DC148H3 MK-2206 Ewing sarcoma (Cell Line: TC-71) [3]
MK-2206 + Bardoxolone methyl DC4LR26 MK-2206 Hodgkin lymphoma (Cell Line: U-HO1) [3]
NVP-AUY922 + Bardoxolone methyl DCKHGOS NVP-AUY922 Ewing sarcoma (Cell Line: TC-71) [3]
Omacetaxine mepesuccinate + Bardoxolone methyl DCGFV07 Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [4]
OSI-027 + Bardoxolone methyl DCUPA0V OSI-027 Ewing sarcoma (Cell Line: TC-71) [3]
OSI-027 + Bardoxolone methyl DC1LJNL OSI-027 Hodgkin lymphoma (Cell Line: U-HO1) [3]
Panobinostat + Bardoxolone methyl DC2CYK1 Panobinostat Ewing sarcoma (Cell Line: TC-71) [3]
PHA-739358 + Bardoxolone methyl DCOGSTJ PHA-739358 Ewing sarcoma (Cell Line: TC-71) [3]
SNX-5422 + Bardoxolone methyl DCNEYZ2 SNX-5422 Ewing sarcoma (Cell Line: TC-71) [3]
Steroid derivative 1 + Bardoxolone methyl DCW1MDW Steroid derivative 1 Ewing sarcoma (Cell Line: TC-71) [3]
THAPSIGARGIN + Bardoxolone methyl DCPH2XA THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [3]
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⏷ Show the Full List of 78 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.