Details of the Drug Combinations

General Information of This Drug (ID: DMOWZ6B)

Drug Name

Fluconazole DMOWZ6B

Synonyms

Afungil; Alflucoz; Baten; Beagyne; Biocanol; Biozolene; Canzol; Cryptal; Diflazon; Diflucan; Dimycon; Elazor; FCZ; FLCZ; Flucazol; FlucoLich; Flucobeta; Fluconazol; Fluconazolum; Flucostat; Flukezol; Flunazul; Flunizol; Fluzone; Forcan; Fuconal; Fungata; Lavisa; Loitin; Mutum; Neofomiral; Oxifugol; Oxifungol; Pritenzol; Solacap; Syscan; TPF; Triflucan; Zemyc; Zoltec; Zonal; AbZ Brand of Fluconazole; Aliud Brand of Fluconazole; Alpharma Brand of Fluconazole; Apo Fluconazole; Apotex Brand of Fluconazole; Armstrong Brand of Fluconazole; Betapharm Brand of Fluconazole; Chemia Brand of Fluconazole; Ct Arzneimittel Brand of Fluconazole; Effik Brand of Fluconazole; Fluc Hexal; Fluconazol AL; Fluconazol AbZ; Fluconazol Isis; Fluconazol Stada; Fluconazol [Spanish]; Fluconazol ratiopharm; Fluconazol von ct; Fluconazolum [Latin]; Hexal Brand of Fluconazole; Lesvi Brand of Fluconazole; Lichtenstein Brand of Fluconazole; Mack Brand of Fluconazole; Pfizer Brand of Fluconazole; Pfleger Brand of Fluconazole; Ratiopharm Brand of Fluconazole; SAT Brand of Fluconazole; Silanes Brand of Fluconazole; Stada Brand of Fluconazole; Vita Brand of Fluconazole; F0677; Fluconazole in combination with MGCD290; UK 49858; UK49858; Alfumet (TN); Apo-Fluconazole; Ct-Arzneimittel Brand of Fluconazole; DIFLUCAN IN DEXTROSE 5% IN PLASTIC CONTAINER; DRG-0005; Diflucan (TN); Fluconazol-Isis; Fluconazol-ratiopharm; Fluconazole & Bovine Lactoferrin; Fluconazole & Human recombinant granulocyte colony stimulating factor; Fluconazole & hGCSF; Fluconazole in dextrose 5% in plastic container; Flucytosine & Nyotran; GL663142 & Fluconazole; KS-1059; Trican (TN); UK-49858; DIFLUCAN IN SODIUM CHLORIDE 0.9%; DIFLUCAN IN SODIUM CHLORIDE 0.9%IN PLASTIC CONTAINER; Fluconazole in sodium chloride 0.9%; Fluconazole in sodium chloride 0.9% in plastic container; Flucytosine & Nyotran(Liposomal Nystatin); XMP.284 & Fluconazole; XMP.366 & Fluconazole; XMP.391 & Fluconazole; Diflucan, Trican, Alfumet, Fluconazole; Fluconazole & MC-510,011; Fluconazole (JAN/USAN/INN); Fluconazole [USAN:INN:BAN:JAN]; 2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2,4-difluoro-,1-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL; 2-(2,4-Difluoro-phenyl)-1,3-bis-[1,2,4]triazol-1-yl-propan-2-ol; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)-2-propanol; 2-(2,4-Difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol; 2-(2,4-Difluorophenyl)-1,3-di-1H-1,2,4-triazol-1-ylpropan-2-ol; 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol

Indication

Disease Entry	ICD 11	Status	REF
Cryptococcal meningitis	N.A.	Approved	[1]
Fungal infection	1F29-1F2F	Approved	[2]
Invasive candidiasis	1F23	Approved	[1]
Mycoses	1F2Z	Approved	[1]
Oral candidiasis	1F23.0	Approved	[1]
Autoimmune polyendocrine syndrome type 1	N.A.	Investigative	[1]
Candidemia	1F23.3Y	Investigative	[1]
Esophageal candidiasis	N.A.	Investigative	[1]
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Therapeutic Class

Antifungal Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Fluconazole + Ruxolitinib	DC1UHAH	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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18 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Anidulafungin + Fluconazole	DCPOWF5	Anidulafungin	Candidemia	[4]
F901318 + Fluconazole	DCNQDSK	F901318	Invasive Aspergillosis	[5]
Fluconazole + Posaconazole	DC3TZ23	Posaconazole	Candidiasis	[6]
Fluconazole + Amphotericin B	DCPVWQW	Amphotericin B	Cryptococcal Meningitis	[7]
Fluconazole + Boric acid	DC0R3PJ	Boric acid	Candidiasis, Vulvovaginal	[8]
Flucytosine + Fluconazole	DCUUT8M	Flucytosine	Cryptococcal Meningitis	[9]
Itraconazole + Fluconazole	DCQDFVA	Itraconazole	Tinea Versicolor	[10]
Micafungin + Fluconazole	DCJ4T47	Micafungin	Stem Cell Transplantation	[11]
Relugolix + Fluconazole	DCAIRXX	Relugolix	Prostate Cancer	[12]
Rifampicin + Fluconazole	DCRLENZ	Rifampicin	Drug Interactions	[13]
Voriconazole + Fluconazole	DCFO6JI	Voriconazole	Fungal Infection	[14]
Fluconazole + Levofloxacin	DC9QNZV	Levofloxacin	Stem Cell Transplant Complications	[15]
Zinc Sulfate + Fluconazole	DCV5GP2	Zinc Sulfate	Stem Cell Transplant Complications	[15]
Caspofungin + Fluconazole	DCU1WYY	Caspofungin	Candidiasis, Invasive	[16]
Isoniazid + Fluconazole	DC1V49W	Isoniazid	Human Immunodeficiency Virus	[17]
SCY-078 + Fluconazole	DC84E2P	SCY-078	Recurrent Vulvovaginal Candidiasis	[18]
Sertraline + Fluconazole	DCLJO0R	Sertraline	Cryptococcosis	[19]
Nevirapine + Fluconazole	DCRD6FO	Nevirapine	HIV Infections	[20]
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⏷ Show the Full List of 18 DrugCom(s)

References

1	Fluconazole FDA Label
2	Fluconazole use as an important risk factor in the emergence of fluconazole-resistant Candida glabrata fungemia. Arch Intern Med. 2009 Aug 10;169(15):1444-5; author reply 1445.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT00761267) Study To Assess Pharmacokinetics, Safety & Efficacy of Anidulafungin When Treating Children With Invasive Candidiasis
5	ClinicalTrials.gov (NCT02730442) Study of Potential for Interaction of Fluconazole With F901318
6	ClinicalTrials.gov (NCT03828773) PTX3-targeted Antifungal Prophylaxis
7	ClinicalTrials.gov (NCT00145249) Amphotericin Alone or in Combination With Fluconazole for AIDS-Associated Meningitis
8	ClinicalTrials.gov (NCT04930107) Vulvovaginal Candidiasis in Canadian Females
9	ClinicalTrials.gov (NCT01715922) Study Evaluating Efficiency and Tolerance of High-dose Fluconazole Associated With Flucytosine as Induction Therapy for Cryptococcal Meningitis Associated With HIV in Sub-saharan Africa
10	ClinicalTrials.gov (NCT05862714) Comparison of Efficacy of Single Oral Dose Fluconazole and Itraconazole in Patients With Pityriasis Versicolor
11	ClinicalTrials.gov (NCT01950507) Evaluation of Budesonide and How It Interacts With Antifungal Drugs in People With Gastrointestinal Graft-Versus-Host Disease
12	ClinicalTrials.gov (NCT02093390) A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects
13	ClinicalTrials.gov (NCT00964106) Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation
14	ClinicalTrials.gov (NCT01503515) Caspofungin Acetate, Fluconazole, or Voriconazole in Preventing Fungal Infections in Patients Following Donor Stem Cell Transplant
15	ClinicalTrials.gov (NCT03159845) Zinc as Enhancer in Immune Recovery After Stem Cell Transplantation for Hematological Malignancies
16	ClinicalTrials.gov (NCT05178862) A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole
17	ClinicalTrials.gov (NCT01825031) Reduction of EArly mortaLITY in HIV-infected Adults and Children Starting Antiretroviral Therapy
18	ClinicalTrials.gov (NCT04029116) Phase 3 Study of Oral Ibrexafungerp (SCY-078) Vs. Placebo in Subjects With Recurrent Vulvovaginal Candidiasis (VVC)
19	ClinicalTrials.gov (NCT03002012) Cryptococcal Antigen Screening Plus Sertraline
20	ClinicalTrials.gov (NCT02181946) Effects of Nevirapine on the Steady State Pharmacokinetics of Fluconazole in HIV Positive Patients