Details of the Drug Combinations

General Information of This Drug (ID: DMP56WJ)

Drug Name
CF102   DMP56WJ
Synonyms
2-Cl-IB-Meca; 163042-96-4; Cl-IB-MECA; Namodenoson; C-Ibza-MU; CF-102; CI-IB-MECA; (2S,3S,4R,5R)-5-(2-Chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide; UNII-Z07JR07J6C; 2Cl-IB-MECA; 1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE; CHEMBL431733; Z07JR07J6C; CF102; 2-Chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide
Indication
Disease Entry ICD 11 Status REF
Hepatocellular carcinoma 2C12.02 Phase 2 [1]
Hepatitis C virus infection 1E51.1 Phase 1/2 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

15 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abexinostat + CF102 DC11TYY Abexinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
ABT-199 + CF102 DCCFSG1 ABT-199 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
BMS-754807 + CF102 DCLKY6W BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Carfilzomib + CF102 DCUITO2 Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + Buparlisib DCF81N6 Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + JQ1 DCVCNOI JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + Carfilzomib DCZDHCG Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + RTB101 DCMFQ1N RTB101 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + Gemcitabine DCY462G Gemcitabine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + Marizomib DCNS6P4 Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
CF102 + Idarubicin DC0DECY Idarubicin Glioblastoma? (Cell Line: T98G) [3]
CF102 + PF-562271 DCNDUT5 PF-562271 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
Citarinostat + CF102 DCI50WF Citarinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
MK-2206 + CF102 DC3BKWJ MK-2206 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
RTB101 + CF102 DC9WTC5 RTB101 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
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⏷ Show the Full List of 15 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 2011 Pipeline of Can-Fite BioPharm.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.