Details of the Drug Combinations

General Information of This Drug (ID: DMPAJ41)

Drug Name
BIIB-021   DMPAJ41
Synonyms
CNF-2024; CNF-3647; EC-129; EC-137; EC-138; EC-141; EC-144; EC-146; EC-147; EC-151; EC-78; EC-89; EC-145, Conforma; EC-82, Conforma; Hsp90 inhibitor (cancer), Biogen Idec; Synthetic Hsp90 inhibitors (cancer), Conforma; Hsp90 inhibitors (synthetic, cancer), Conforma
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

25 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BIIB-021 + Gefitinib DCUOZJ7 Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + PD-0325901 DCYA6DX PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + Trametinib DCS17Z2 Trametinib Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + Cladribine DCCE2RM Cladribine Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + Panobinostat DCBZGCD Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BIIB-021 + Parthenolide DCQLH1N Parthenolide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + THAPSIGARGIN DCQ31VZ THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + Mifepristone DC43FZC Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + Pelitinib DCMRBMR Pelitinib Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + OSI-027 DC5IV1B OSI-027 Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + Tamoxifen DCVXIGA Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + GSK2126458 DC6SOH9 GSK2126458 Glioblastoma (Cell Line: JHH-136) [2]
BIIB-021 + Ciclopirox DCIZZ9R Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + Chloroquine DC49APV Chloroquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BIIB-021 + Mefloquine DCNM7P1 Mefloquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
BMS-754807 + BIIB-021 DCGQUXT BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CA4P + BIIB-021 DCJRX1D CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + BIIB-021 DCFCHTQ CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
GDC-0980/RG7422 + BIIB-021 DCV6540 GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Mebendazole + BIIB-021 DCQD76E Mebendazole Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PAC1 + BIIB-021 DCRKG08 PAC1 Glioblastoma (Cell Line: JHH-136) [2]
PF-04691502 + BIIB-021 DCC06D3 PF-04691502 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
RTB101 + BIIB-021 DCXD9FC RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SCH 727965 + BIIB-021 DC3WRRS SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Trametinib + BIIB-021 DCRC1YZ Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 25 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Exemestane + BIIB-021 DCPE3U2 Exemestane Breast Cancer [4]
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References

1 ClinicalTrials.gov (NCT00618319) An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal Stromal Tumors (GIST). U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT01004081) Hormone Receptor Positive Metastatic Breast Cancer (HR+ mBC) BIIB021 Plus Aromasin Schedule Finding