Details of the Drug Combinations

General Information of This Drug (ID: DMQCTIH)

• Drug Name: Digoxin (DMQCTIH)
• Synonyms: digoxin; 20830-75-5; 12beta-Hydroxydigitoxin; Digoxine; Lanoxin; Lanoxicaps; Digossina; Digoxina; Digoxinum; Digosin; Lanicor; Digacin; Dilanacin; CHEBI:4551; MLS000069819; Lanacordin; Cardiogoxin; Eudigox; Davoxin; SMR000059217; Rougoxin; Mapluxin; Lenoxin; Lanacrist; Dynamos; Vanoxin; Neo-Lanicor; Lanoxin PG; Digoxin Pediatric; Digoxin Nativelle; SK-Digoxin; UNII-73K4184T59; Homolle's digitalin; Hemigoxine Nativelle; MFCD00003674; Digitek (TN); Lanoxicaps (TN); Lanoxin (TN); Digoxin (JP15/USP); (3beta,5beta,12beta)-3-{[2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl]oxy}-12,14-dihydroxycard-20(22)-enolide; 4-[(1S,2S,5S,7R,10R,11S,14R,15S,16R)-5-{[(2R,4S,5S,6R)-5-{[(2S,4S,5S,6R)-5-{[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-4-hydroxy-6-methyloxan-2-yl]oxy}-11,16-dihydroxy-2,15-dimethyltetracyclo[8700^{2,7}; [3H]digoxin

Indication

Arrhythmia; ICD 11: BC9Z; Status: Approved [1]; Atrial fibrillation; ICD 11: BC81.3; Status: Approved [2]; Chronic heart failure; ICD 11: BD1Z; Status: Approved [2]; Congestive cardiac insufficiency; ICD 11: BD1Z; Status: Approved [1]; Heart failure; ICD 11: BD10-BD13; Status: Approved [1]

• Therapeutic Class: Antiarrhythmic Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Digoxin + Idarubicin	DCCXL3V	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]

19 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AKB-6548 + Digoxin	DCSN04H	AKB-6548	Drug Interaction Potentiation	[4]
Canagliflozin + Digoxin	DCY6THR	Canagliflozin	Type2 Diabetes Mellitus	[5]
Dapagliflozin + Digoxin	DCRMPFK	Dapagliflozin	Type 2 Diabetes Mellitus	[6]
Digoxin + Isavuconazole	DCCPZW3	Isavuconazole	Pharmacokinetics of Isavuconazole	[7]
Digoxin + DIMEBOLIN	DCLK6GA	DIMEBOLIN	Alzheimer Disease	[8]
Digoxin + GSK2140944	DCTS3O4	GSK2140944	Infections, Bacterial	[9]
Digoxin + Decitabine	DCCYHK2	Decitabine	Acute Myeloid Leukemia	[10]
Edivoxetine + Digoxin	DCU3OR1	Edivoxetine	Major Depressive Disorder	[11]
Fluvoxamine + Digoxin	DC0I4GT	Fluvoxamine	Depression	[12]
Lapatinib + Digoxin	DC1JKPH	Lapatinib	Neoplasms, Breast	[13]
Regorafenib + Digoxin	DCX2L72	Regorafenib	Neoplasms	[14]
Rivoceranib + Digoxin	DCFD368	Rivoceranib	Advanced Solid Tumor	[15]
Rolapitant + Digoxin	DCNETTW	Rolapitant	Chemotherapy-induced Nausea and Vomiting	[16]
Trametinib + Digoxin	DCVO1IC	Trametinib	Melanoma	[17]
Tucatinib + Digoxin	DCOZDF9	Tucatinib	Drug-drug Interaction	[18]
Vemurafenib + Digoxin	DC0N038	Vemurafenib	Malignant Melanoma, Neoplasms	[19]
Digoxin + Capecitabine	DCA8BX6	Capecitabine	Metastatic Breast Cancer	[20]
Digoxin + Flecainide	DCP42W2	Flecainide	Fetal Atrial Flutter Without Hydrops	[21]
Sotalol + Digoxin	DC851I0	Sotalol	Fetal Atrial Flutter Without Hydrops	[21]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4726).
• [2] Digoxin FDA Label
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT03801759) Drug-Drug Interaction Study of Vadadustat With Digoxin, Adefovir and Furosemide
• [5] ClinicalTrials.gov (NCT03197324) Bexagliflozin Drug/Drug Interaction Study With Digoxin
• [6] ClinicalTrials.gov (NCT00904176) Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
• [7] ClinicalTrials.gov (NCT01582412) Drug Interaction Study of Isavuconazole and Digoxin
• [8] ClinicalTrials.gov (NCT00831506) Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects
• [9] ClinicalTrials.gov (NCT04493931) Drug-drug Interaction Study of Gepotidacin
• [10] ClinicalTrials.gov (NCT03113071) Safety and Activity of Digoxin With Decitabine in Adult AML and MDS
• [11] ClinicalTrials.gov (NCT01266590) A Study of LY2216684 and Digoxin in Healthy Subjects
• [12] ClinicalTrials.gov (NCT01704638) Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes
• [13] ClinicalTrials.gov (NCT00650910) Study To Examine The Effects Of Lapatinib On The Pharmacokinetics Of Digoxin In Subjects w/ ErbB2 Positive Breast Cancer
• [14] ClinicalTrials.gov (NCT02106845) Effect of Regorafenib on Digoxin and Rosuvastatin in Patients With Advanced Solid Malignant Tumors.
• [15] ClinicalTrials.gov (NCT04322552) A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Transporter Pgp Substrate Digoxin in Advanced Solid Tumor Subjects
• [16] ClinicalTrials.gov (NCT02434861) An Open Label, Single Dose, Three Part Study to Assess the Effects of Rolapitant (2 mg/mL IV Solution) on the Pharmacokinetics of Digoxin; Sulfasalazine; and the Cooperstown Cocktail (Midazolam, Omeprazole, Warfarin, Caffeine, and Dextromethorphan in Healthy Subjects
• [17] ClinicalTrials.gov (NCT02915666) A Clinical Trial of Patients With Melanoma
• [18] ClinicalTrials.gov (NCT03723395) A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
• [19] ClinicalTrials.gov (NCT01765569) A Pharmacokinetics Study to Investigate the Effect of Vemurafenib on Digoxin in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma
• [20] ClinicalTrials.gov (NCT01887288) Capecitabine With Digoxin for Metastatic Breast Cancer
• [21] ClinicalTrials.gov (NCT02624765) Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)