Details of the Drug Combinations

General Information of This Drug (ID: DMQVRZH)

Drug Name

Vitamin B3 DMQVRZH

Synonyms

Niacin (TN); Niacinamide (TN); Nicotinamide (TN)

Indication

Disease Entry	ICD 11	Status	REF
Chronic renal failure	GB61.Z	Approved	[1]
Hypercholesterolaemia	5C80.0	Approved	[2]
Hyperlipidemia	5C80.Z	Approved	[3]
Hyperlipidemia, familial combined, LPL related	N.A.	Approved	[4]
Hypertriglyceridemia	5C80.1	Approved	[5]
Lipid metabolism disorder	5C52.Z	Approved	[6]
Primary hypercholesterolemia	5C80.00	Approved	[7]
Psoriasis	EA90	Approved	[8]
Vitamin deficiency	5B55-5B71	Approved	[9]
------------------------------------------------------------------------------------


⏷ Show the Full List of Indication(s)

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Vitamin B3 + Idarubicin	DCWTF3Z	Idarubicin	Glioblastoma? (Cell Line: T98G)	[10]
------------------------------------------------------------------------------------

1 Discontinued Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
LAROPIPRANT + Vitamin B3	DC7OYWQ	LAROPIPRANT	Dyslipidemia	[11]
------------------------------------------------------------------------------------

References

1	Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety. Exp Dermatol. 2019 Feb;28 Suppl 1:15-22.
2	Vitamin B3 impairs reverse cholesterol transport in Apolipoprotein E-deficient mice. Clin Investig Arterioscler. 2019 Nov-Dec;31(6):251-260.
3	Vitamin B3. 2024 Feb 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
4	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
5	Niacin: chemical forms, bioavailability, and health effects. Nutr Rev. 2012 Jun;70(6):357-66.
6	Hakozaki T, Minwalla L, Zhuang J, Chhoa M, Matsubara A, Miyamoto K, Greatens A, Hillebrand GG, Bissett DL, Boissy RE: The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002 Jul;147(1):20-31.
7	Extended-release niacin (nicotinic acid)/laropiprant. Drugs. 2009 Aug 20;69(12):1665-79.
8	Cosmeceutical Aptitudes of Niacinamide: A Review. Recent Adv Antiinfect Drug Discov. 2021;16(3):196-208.
9	Hydrosoluble vitamins. Handb Clin Neurol. 2014;120:891-914.
10	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
11	ClinicalTrials.gov (NCT01054508) Effect of Tredaptive on Serum Lipoproteins and Inflammatory Markers. U.S. National Institutes of Health.