Details of the Drug Combinations

General Information of This Drug (ID: DMRTSGP)

• Drug Name: Amiloride (DMRTSGP)
• Synonyms: Amiclaran; Amilorida; Amiloridum; Amipramidin; Amipramizid; Amipramizide; Amiprazidine; Amyloride; Guanamprazin; Guanamprazine; Midamor; Amiloride HCL; Amiloride hydrochloride hydrate; Amiclaran (TN); Amikal (Hydrochloride dihydrate); Amilorida [INN-Spanish]; Amiloride (INN); Amiloride [INN:BAN]; Amiloridum [INN-Latin]; Biduret (TN); Midamor (Hydrochloride dihydrate); MK-870 (Hydrochloride dihydrate); AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8)); N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide; N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid; Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride; 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide; 3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide; 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide; 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide; Amiloride (Na-Ca chanel blocker)

Indication

Congestive heart failure; ICD 11: BD10; Status: Approved [1]; Edema; ICD 11: MG29; Status: Approved [2]

• Therapeutic Class: Diuretics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

54 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Amiloride	DCWIS3C	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acitretin + Amiloride	DCNEG2E	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Epinephrine	DCSJ323	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Fomepizole	DC6MBNE	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Testosterone	DCFVRKT	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Triapine	DCFZO3Q	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Everolimus	DCAWTUW	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Metyrosine	DC9XX2R	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Terameprocol	DCJ4SVW	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Itraconazole	DCL0HWQ	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + K-134	DCY4B92	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Cilastatin	DCBRLJ6	Cilastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Phensuximide	DCAOCCB	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Pentamidine	DCM07CO	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Arfolitixorin	DCS59GQ	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Niclosamide	DCOHIOE	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Tiagabine	DC1M9UM	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Diazoxide	DCG4TWD	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Entacapone	DC7FOTX	Entacapone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Idarubicin	DCA1FJ9	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Methylene blue	DCPEQC0	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Moricizine	DC7NR2G	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Topotecan	DC4KEAE	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Cefmenoxime	DCAFP34	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Trimethobenzamide	DCL7JSO	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Leflunomide	DCOS1HC	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Amantadine	DC0YU7X	Amantadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Mycophenolic acid	DCR68DT	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Lacosamide	DCXAA1J	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Doxorubicin	DC9GQSU	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + PMID28870136-Compound-43	DC0QQS2	PMID28870136-Compound-43	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Vorinostat	DCZ5QLB	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Cerivastatin	DCCMZDG	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Albendazole	DCMP9SZ	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + GSK2194069	DC8LPUT	GSK2194069	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Atovaquone + Amiloride	DCYRI6I	Atovaquone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Amiloride	DCPI259	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Amiloride	DCAANGJ	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Amiloride	DC6TWFQ	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cinacalcet + Amiloride	DC13QZB	Cinacalcet	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Amiloride	DCTOTEK	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Estramustine + Amiloride	DCVZSJD	Estramustine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Etomidate + Amiloride	DC6LW8Q	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Flavonoid derivative 1 + Amiloride	DCGIUNQ	Flavonoid derivative 1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Amiloride	DCIRC9D	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Amiloride	DCO7ML9	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Amiloride	DCML91Y	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
LY03004 + Amiloride	DC837XS	LY03004	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Amiloride	DCO4GBB	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Nitisinone + Amiloride	DCIVA4S	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Amiloride	DCUY8H6	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trazodone + Amiloride	DCZ5T7N	Trazodone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Amiloride	DC8ICTI	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Valproic Acid + Amiloride	DCRFALG	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Bendroflumethiazide + Amiloride	DCEZK68	Bendroflumethiazide	Heart Failure	[4]
Cinacalcet + Amiloride	DCPVO7P	Cinacalcet	Primary Hyperparathyroidism	[5]
Chlorthalidone + Amiloride	DCVQPUE	Chlorthalidone	Hypertension	[6]
Amiloride + Hydrochlorothiazide	DC7SOWJ	Hydrochlorothiazide	Chronic Kidney Disease	[7]
Furosemide + Amiloride	DCGH818	Furosemide	Hypertension Resistant to Conventional Therapy	[8]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2421).
• [2] Amiloride FDA Label
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT05753059) Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
• [5] ClinicalTrials.gov (NCT02525796) Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism
• [6] ClinicalTrials.gov (NCT03928145) Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.
• [7] ClinicalTrials.gov (NCT02875886) DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease
• [8] ClinicalTrials.gov (NCT02832973) Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension