Details of the Drug Combinations

General Information of This Drug (ID: DMS60RB)

Drug Name

Levofloxacin DMS60RB

Synonyms

Aeroquin; Cravit; Elequine; Floxacin; Floxel; Iquix; LFX; LVX; Leroxacin; Lesacin; Levaquin; Levofloxacine; Levofloxacino; Levofloxacinum; Levokacin; Levox; Levoxacin; Mosardal; Nofaxin; Oftaquix; Quixin; Reskuin; Tavanic; Volequin; Cravit Ophthalmic; DR 3354; DR3355; HR 355; Cravit (TN); D-Levofloxacin; DR-3355; HR-355; Iquix (TN); L-Ofloxacin; LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER; Levaquin (TN); Levofloxacin (INN); Levofloxacin tablet, suspension or intravenous; Levofloxacine [INN-French]; Levofloxacino [INN-Spanish]; Levofloxacinum [INN-Latin]; MP-376; Oftaquix (TN); Quixin (TN); R-Ofloxacin; RWJ 25213-097; RWJ-25213; Tavanic (TN); Levofloxacin [USAN:INN:JAN]; DR-3355: L-isomer of ofloxacin; Ofloxacin S-(-)-form; S-(-)-Ofloxacin; (-)-(S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyridol[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate; (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7Hpyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate; (3S)-9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; (R)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (R)-isomer; (S)-(-)-Ofloxacin; (S)-9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid; (S)-Ofloxacin

Indication

Disease Entry	ICD 11	Status	REF
Acute maxillary sinusitis	N.A.	Approved	[1]
Anthrax	1B97	Approved	[1]
Bacterial infection	1A00-1C4Z	Approved	[2]
Latent tuberculosis infection	N.A.	Approved	[1]
Mycoplasma pneumoniae pneumonia	N.A.	Approved	[1]
Pyelonephritis	N.A.	Approved	[1]
Staphylococcal pneumonia	N.A.	Approved	[1]
Staphylococcus aureus infection	N.A.	Approved	[1]
Streptococcal pneumonia	N.A.	Approved	[1]
Pneumonia caused by chlamydia	N.A.	Investigative	[1]
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Therapeutic Class

Antibiotics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Levofloxacin + Panobinostat	DC5HW8F	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Levofloxacin + Idarubicin	DCSVAE6	Idarubicin	Glioblastoma? (Cell Line: T98G)	[3]
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22 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Betamethasone + Levofloxacin	DCV0P6P	Betamethasone	Corneal Disease	[4]
Esomeprazole + Levofloxacin	DC6IVT1	Esomeprazole	Helicobacter Pylori Infection	[5]
Esomeprazole + Levofloxacin	DC5OPJP	Esomeprazole	Helicobacter Pylori Infection	[5]
Levofloxacin + Azithromycin	DC2K64F	Azithromycin	Acute Watery Diarrhea	[6]
Levofloxacin + Pantoprazole	DCFQPL3	Pantoprazole	Melatonin Deficiency	[7]
Levofloxacin + Metronidazole	DCBMXRS	Metronidazole	Community-Acquired Pneumonia	[8]
Levofloxacin + Cefuroxime	DC10G6Q	Cefuroxime	Complication of Surgical Procedure	[9]
Reserpine + Levofloxacin	DC7UO5I	Reserpine	Traumatic Brain Injury	[10]
Vibegron + Levofloxacin	DCWNAK7	Vibegron	Overactive Bladder	[11]
Fluconazole + Levofloxacin	DC9QNZV	Fluconazole	Stem Cell Transplant Complications	[12]
Levofloxacin + Cloxacillin	DCNQ18C	Cloxacillin	Staphylococcus	[13]
Meropenem + Levofloxacin	DC7FRNK	Meropenem	Complicated Urinary Tract Infection	[14]
Plazomicin + Levofloxacin	DC1XYE7	Plazomicin	Complicated Urinary Tract Infection	[14]
Rifampicin + Levofloxacin	DCL6ZHG	Rifampicin	Infective Endocarditis	[15]
Aspirin + Levofloxacin	DCTW309	Aspirin	Prostate Cancer	[16]
Ceftriaxone + Levofloxacin	DCPR2ZA	Ceftriaxone	Cholangitis	[17]
Esomeprazole + Levofloxacin	DCPJ5KC	Esomeprazole	Helicobacter Pylori Infection	[18]
Levofloxacin + Pantoprazole	DCXGPBT	Pantoprazole	Helicobacter Pylori Infection	[19]
Levofloxacin + Amoxicillin	DC6FL5U	Amoxicillin	Functional Dyspepsia	[20]
Levofloxacin + Amoxicillin	DC5JOLC	Amoxicillin	Antimicrobial Susceptibility Testing	[21]
Prednisolone + Levofloxacin	DCYI131	Prednisolone	Mycoplasma Pneumoniae Pneumonia	[22]
Rabeprazole + Levofloxacin	DC695L1	Rabeprazole	Helicobacter Pylori Infection	[23]
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References

1	Levofloxacin FDA Label
2	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT02148016) Corneal Epithelium Repair and Therapy Using Autologous Limbal Stem Cell Transplantation
5	ClinicalTrials.gov (NCT02596620) Levofloxacin-containing Therapies In Second Line Helicobacter Pylori Eradication
6	ClinicalTrials.gov (NCT01618591) Trial Evaluating Ambulatory Treatment of Travelers' Diarrhea
7	ClinicalTrials.gov (NCT04352062) Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia
8	ClinicalTrials.gov (NCT00752947) Efficacy and Safety Trial to Assess Moxifloxacin in Treating Community-Acquired Pneumonia (CAP) With Aspiration Factors
9	ClinicalTrials.gov (NCT02789579) The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy
10	ClinicalTrials.gov (NCT06199778) Effect of Intermittent Oro-esophageal Tube Feeding on Severe Traumatic Brain Injury Patients With Tracheostomy
11	ClinicalTrials.gov (NCT01500382) A Study of the Pharmacokinetics and Pharmacodynamics of Vibegron (MK-4618) in Women With Overactive Bladder (MK-4618-004)
12	ClinicalTrials.gov (NCT03159845) Zinc as Enhancer in Immune Recovery After Stem Cell Transplantation for Hematological Malignancies
13	ClinicalTrials.gov (NCT01875263) Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.
14	ClinicalTrials.gov (NCT02486627) A Study of Plazomicin Compared With Meropenem for the Treatment of Complicated Urinary Tract Infection (cUTI) Including Acute Pyelonephritis (AP)
15	ClinicalTrials.gov (NCT02701608) Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus
16	ClinicalTrials.gov (NCT02757365) Efficiency Study of Aspirin to Prevent the Occurrence of Prostate Cancer
17	ClinicalTrials.gov (NCT03087656) Antibiotics to Decrease Post ERCP Cholangitis
18	ClinicalTrials.gov (NCT04432233) Intravenous Triple Therapy in the Treatment of Helicobacter Pylori Infection and Related Complications Caused by Active Peptic Ulcer Disease
19	ClinicalTrials.gov (NCT02466919) Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients
20	ClinicalTrials.gov (NCT01667718) Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment
21	ClinicalTrials.gov (NCT03139253) Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment
22	ClinicalTrials.gov (NCT02618057) Effects of Oral Steroid in Mycoplasma Pneumoniae Pneumonia
23	ClinicalTrials.gov (NCT05023577) Antibiotic Combination for H. Pylori Eradication in Penicillin-allergic Patients