Details of the Drug Combinations

General Information of This Drug (ID: DMS610L)

Drug Name
PF-04691502   DMS610L
Synonyms
PF-04691502; 1013101-36-4; PF 04691502; UNII-4W39NS61KI; 4W39NS61KI; 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one; CHEMBL1234354; PF04691502; 2-Amino-8-[trans-4-(2-Hydroxyethoxy)cyclohexyl]-6-(6-Methoxypyridin-3-Yl)-4-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; 2-Amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
Indication
Disease Entry ICD 11 Status REF
Endometrial cancer 2C76 Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

32 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
CA4P + PF-04691502 DCI5SJW CA4P Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dasatinib + PF-04691502 DCASYJS Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dasatinib + PF-04691502 DC3BJQ0 Dasatinib Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Flavopiridol + PF-04691502 DCBGPJY Flavopiridol Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + Gefitinib DCB1USU Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + Gefitinib DC1GLS3 Gefitinib Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-04691502 + Ruxolitinib DCIRMNC Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
PF-04691502 + PD-0325901 DCQSAQM PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + PD-0325901 DCCF0AG PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-04691502 + Trametinib DCBFALZ Trametinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
PF-04691502 + Trametinib DC3WYUJ Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
PF-04691502 + Trametinib DCFH8KY Trametinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PF-04691502 + Panobinostat DCHBMQM Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PF-04691502 + Ym155 DCWEZCW Ym155 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + Olaparib DCTYYO1 Olaparib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
PF-04691502 + Olaparib DCPM7GP Olaparib Ewing sarcoma (Cell Line: TC-71) [2]
PF-04691502 + Olaparib DCF07W2 Olaparib Ewing sarcoma (Cell Line: EW-8) [2]
PF-04691502 + Olaparib DCAB5J3 Olaparib Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-04691502 + Cantharidin DCTKB59 Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + THAPSIGARGIN DC33LQL THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + THAPSIGARGIN DCBJEA7 THAPSIGARGIN Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-04691502 + Cotellic DC8GKV1 Cotellic Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
PF-04691502 + Cotellic DCUU94U Cotellic Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
PF-04691502 + Cotellic DC7OIAL Cotellic Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PF-04691502 + Niclosamide DC7FYVW Niclosamide Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + Niclosamide DCNH51H Niclosamide Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-04691502 + AS602868 DCTJHV3 AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + Tamoxifen DCIAG4B Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + Tamoxifen DCMDBHU Tamoxifen Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-04691502 + Idarubicin DC9MFCR Idarubicin Glioblastoma? (Cell Line: T98G) [2]
PF-04691502 + Ciclopirox DCPJDTH Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-04691502 + BIIB-021 DCC06D3 BIIB-021 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
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⏷ Show the Full List of 32 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7936).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.