Details of the Drug Combinations

General Information of This Drug (ID: DMTW6IU)

• Drug Name: Methadone (DMTW6IU)
• Synonyms: Adanon; Algovetin; Althose; Amidon; Amidone; Biscuits; Dextromethadone; Diaminon; Dollies; Dolly; Dolophin; Dolophine; Heptadone; Heptanon; Ketalgin; Levometadona; Levomethadonum; Levothyl; Metadona; Metadone; Metasedin; Methadon; Methadona; Methadonum; Methaquaione; Phenadone; Polamidone; Polamivet; Westadone; Dolophine HCL; Levomethadone [INN]; Metadona [Spanish]; Metadone [DCIT]; Methadona [Spanish]; Methadone HCL Intensol; Methadone M; Methadonum [Latin]; Racemic methadone; A 4624; AN 148; Hoechst 10820; K 174; Amidone (TN); D-Methadone; Dl-Methadone; Dolophine (TN); Heptadon (TN); Heptanon (pharmaceutical); L-Methadone; L-Polamidon; L-Polamivet; Levometadona [INN-Spanish]; Levomethadonum [INN-Latin]; Metadona [INN-Spanish]; Methadone (BAN); Methadone [INN:BAN]; Methadonum [INN-Latin]; Methadose (TN); Physeptone (TN); Sedo-Rapide; Symoron (TN); Dolophine (*Hydrochloride*); Fenadone (*Hydrochloride*); Heptadone (*Hydrochloride*); Heptanon (*Hydrochloride*); Hoescht 10820 (*Hydrochloride*); Phenadone (*Hydrochloride*); AN-148 (*Hydrochloride*); L-(+)-Methadone; S-(+)-Methadone; D-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; L-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; (+)-Methadone; (+-)-Methadone; (+/-)-Methadone; (+/-)-Tussal; (-)-(R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; (-)-Methadone; (6R)-Methadone; (R)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; (R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone; (S)-6-(Dimethylamino)-4,4-diphenyl-3-heptanone; 3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-(9CI); 6-(Dimethylamino)-4,4-diphenyl-3-heptanone dl-mixture; 6-(dimethylamino)-4,4-diphenylheptan-3-one; 6-Dimethylamino-4,4-diphenyl-3-heptanone; 6-dimethylamino-4,4-di(phenyl)heptan-3-one; 6S-Methadone

Indication

Advanced cancer; ICD 11: 2A00-2F9Z; Status: Approved [1]; Dry cough; ICD 11: MD12; Status: Approved [2]; Pain; ICD 11: MG30-MG3Z; Status: Approved [1]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Buprenorphine + Methadone	DCVMM8X	Buprenorphine	Substance-related Disorders	[3]
Disulfiram + Methadone	DC9EREC	Disulfiram	Cocaine Dependence	[4]
Dolutegravir + Methadone	DC813H1	Dolutegravir	Infections, Human Immunodeficiency Virus and Hepatitis	[5]
Isavuconazole + Methadone	DC4ER67	Isavuconazole	Pharmacokinetics of Isavuconazole	[6]
Isoniazid + Methadone	DCE3BTD	Isoniazid	Opioid Dependence	[7]
Methadone + Modafinil	DC8KO1I	Modafinil	Cocaine Dependence	[8]
MK-1439 + Methadone	DCFDKCK	MK-1439	Human Immunodeficiency Virus (HIV) Infection	[9]
Morphine + Methadone	DCN4K8R	Morphine	Pain	[10]
Morphine + Methadone	DCX6HRV	Morphine	Cancer	[11]
Methadone + Phenobarbital	DCF60XG	Phenobarbital	Neonatal Abstinence Syndrome	[12]
Ketamine + Methadone	DCD1HJT	Ketamine	Laminectomy	[13]

References

• [1] Methadone FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] ClinicalTrials.gov (NCT01560221) Reducing Drug Use and HIV Risk in Drug-dependent Adults Arrested for Prostitution
• [4] ClinicalTrials.gov (NCT00149630) Pharmacogenetics of Disulfiram for Cocaine
• [5] ClinicalTrials.gov (NCT01467518) Methadone-Dolutegravir (DTG - GSK1349572) Drug Interaction Study.
• [6] ClinicalTrials.gov (NCT01582425) Drug Interaction Study of Isavuconazole and Methadone
• [7] ClinicalTrials.gov (NCT03089983) Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
• [8] ClinicalTrials.gov (NCT00838981) Pharmacotherapy & CM for Opioid and Cocaine Dependence
• [9] ClinicalTrials.gov (NCT02715700) Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045)
• [10] ClinicalTrials.gov (NCT00558870) Role of Methadone As Co-Opioid Analgesic
• [11] ClinicalTrials.gov (NCT03324815) Methadone Associated With Morphine for Cancer Pain
• [12] ClinicalTrials.gov (NCT01958476) Improving Outcomes in Neonatal Abstinence Syndrome
• [13] ClinicalTrials.gov (NCT02252432) The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy