Details of the Drug Combinations

General Information of This Drug (ID: DMUKNQ5)

Drug Name
AZD8330   DMUKNQ5
Synonyms
AZD8330; 869357-68-6; AZD-8330; ARRY-424704; ARRY-704; UNII-G4990BOZ66; AZD 8330; 2-((2-fluoro-4-iodophenyl)amino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide; 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide; G4990BOZ66; C16H17FIN3O4; 2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxopyridine-3-carboxamide; RWEVIPRMPFNTLO-UHFFFAOYSA-N
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Discontinued in Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

12 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
AZD8330 + JQ1 DCR4TIG JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AZD8330 + Panobinostat DC5NOMU Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AZD8330 + Alvespimycin hydrochloride DC7DTHY Alvespimycin hydrochloride Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AZD8330 + Vorinostat DCXDJW4 Vorinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + AZD8330 DCQNSOW Bafilomycin A1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BMS-754807 + AZD8330 DC43Z36 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Buparlisib + AZD8330 DC54EJP Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CHS-828 + AZD8330 DCHMCXD CHS-828 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Dasatinib + AZD8330 DCEQ5Y2 Dasatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Mebendazole + AZD8330 DCFWPKH Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-1775 + AZD8330 DC9EKIB MK-1775 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Vincristine + AZD8330 DC3XR9R Vincristine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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⏷ Show the Full List of 12 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8474).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.