Details of the Drug Combinations

General Information of This Drug (ID: DMUNTE3)

Drug Name

Estradiol DMUNTE3

Synonyms

Aerodiol; Alora; Altrad; Aquadiol; Bardiol; Climaderm; Climara; Compudose; Corpagen; Dermestril; Destradiol; Dihydrofolliculin; Dihydromenformon; Dihydrotheelin; Dihydroxyesterin; Dihydroxyestrin; Dihydroxyoestrin; Dimenformon; Diogyn; Diogynets; Divigel; Elestrin; Encore; Esclim; Estrace; Estraderm; Estradiolo; Estradiolum; Estradot; Estraldine; Estrasorb; Estreva; Estrifam; Estring; Estroclim; Estrodiolum; Estrogel; Estrovite; Evamist; Evorel; Extrasorb; Femanest; Femestral; Femestrol; Fempatch; Femtran; Follicyclin; Gelestra; Ginedisc; Ginosedol; GynPolar; Gynergon; Gynestrel; Gynodiol; Gynoestryl; Innofem; Lamdiol; Macrodiol; Macrol; Menest; Menorest; Microdiol; Nordicol; Oesclim; Oestergon; Oestradiol; Oestradiolum; Oestrogel; Oestroglandol; Oestrogynal; Ovahormon; Ovasterol; Ovastevol; Ovociclina; Ovocyclin; Ovocycline; Ovocylin; Perlatanol; Polyestradiol; Primofol; Profoliol; Progynon; Syndiol; Systen; Tradelia; Trocosone; Vagifem; Vivelle; Zerella; Zesteem; Zesteen; Zumenon; Climara Forte; Component of Menrium; Estraderm MX; Estraderm TTS; Estradiolo [DCIT]; Estradiolum [INN]; Estring vaginal ring; Estrofem Forte; Oestradiol Berco; Oestradiol R; Progynon DH; Sandrena Gel; Sisare Gel; Trial SAT; CMC_11154; Compudose 200; Compudose 365; E 2; E 8875; E0025; Epiestriol 50; Estraderm TTS 100; Estraderm TTS 50; Estrapak 50; Estroclim 50; Estrofem 2; Sandrena 1; [3H]]estradiol; Activella (TN); Alora (TN); Alpha-Oestradiol; AngeliQ (TN); B-Estradiol; Beta-Estradiol; Beta-Oestradiol; Beta-estradiol; Cis-Estradiol; Cis-Oestradiol; Climara (TN); D-Estradiol; D-Oestradiol; Divigel (TN); E(sub 2); Elestrin (TN); Estrace (TN); Estraderm (TN); Estraderm TTS (TN); Estradiol [USAN:INN]; Estradiol acetate (TN); Estradiol cypionate (TN); Estradiol valerate (TN); Estradiol-17 beta; Estradiol-17beta; Estrasorb (TN); Estrasorb Topical (TN); Estring (TN); Estrofem (TN); Estrogel (TN); EvaMist (TN); Femring (TN); Innofem (TN); Menostar (TN); Oestradiol-17beta; Progynon-DH; Progynova (TN); S-21400; SK-Estrogens; SL-1100; VIVELLE-DOT; Vagifem (TN); Vivelle (TN); [3H]-estradiol; Estradiol-17-beta; Estradiol-3,17beta; Oestradiol-17-beta; Vivelle-Dot (TN); D-3,17beta-Estradiol; [2,4,6,7-3H]-E2; 17 beta-Estradiol; 17-.BETA.-Estradiol; 17-beta-OH-estradiol; 17-beta-estradiol; 17.beta.-Estradiol; 17.beta.-Oestradiol; 17b-Oestradiol; 17beta oestradiol; 17beta-Estradiol; 17beta-Oestradiol; 3,17-beta-Estradiol; 3,17-beta-Oestradiol; 3,17.beta.-Estradiol; 3,17beta-Estradiol

Indication

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[1]
Breast cancer	2C60-2C65	Approved	[2]
Hot flushes	GA30	Approved	[1]
Infertility	GB04	Approved	[1]
Obsolete atrophic vulva	N.A.	Approved	[1]
Metastatic prostate carcinoma	N.A.	Investigative	[1]
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Therapeutic Class

Estrogens

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

15 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Anastrozole + Estradiol	DC4R260	Anastrozole	Breast Cancer	[3]
Conjugated estrogens + Estradiol	DCM5UAZ	Conjugated estrogens	Urinary Tract Infections	[4]
Dydrogesterone + Estradiol	DC0UMMO	Dydrogesterone	Menopausal and Postmenopausal Disorders	[5]
Estradiol + Naproxen	DC0RRJI	Naproxen	Menorrhagia	[6]
Etonogestrel + Estradiol	DCBPX0C	Etonogestrel	Contraception	[7]
Leuprolide + Estradiol	DC944EK	Leuprolide	Obesity	[8]
Levonorgestrel + Estradiol	DCFICUL	Levonorgestrel	Menopausal and Other Perimenopausal Disorders	[9]
Medroxyprogesterone + Estradiol	DCZ1RTX	Medroxyprogesterone	Alzheimer Disease	[10]
Nomegestrol acetate + Estradiol	DCN6L72	Nomegestrol acetate	Multiple Sclerosis	[11]
Nomegestrol acetate + Estradiol	DCTIEMC	Nomegestrol acetate	Contraception	[7]
Olaparib + Estradiol	DC86LGE	Olaparib	Metastatic Breast Cancer	[12]
Progesterone + Estradiol	DCHEF2V	Progesterone	Postpartum Depression	[13]
Spironolactone + Estradiol	DC9917Y	Spironolactone	Transgender Health	[14]
Misoprostol + Estradiol	DCND5UD	Misoprostol	Miscarriage	[15]
Cyproterone acetate + Estradiol	DCN9CYR	Cyproterone acetate	Transsexualism	[16]
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References

1	Estradiol FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1013).
3	ClinicalTrials.gov (NCT00661531) Estrogen in Postmenopausal Women With ER Positive Metastatic Breast Cancer After Failure of Sequential Endocrine Therapy
4	ClinicalTrials.gov (NCT04301934) Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract Infection
5	ClinicalTrials.gov (NCT02086032) The Effect of Different Types of Progestin on Sleeping of Menopausal Women
6	ClinicalTrials.gov (NCT01165307) Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia
7	ClinicalTrials.gov (NCT01709318) A Dose-Finding Study to Evaluate Ovarian Function and Vaginal Bleeding in Next Generation Rings (P06109/MK-8175A/MK-8342B-012)
8	ClinicalTrials.gov (NCT00687739) Prevention of Obesity in Women Via Estradiol Regulation
9	ClinicalTrials.gov (NCT01613131) Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression
10	ClinicalTrials.gov (NCT00066157) Alzheimer's Disease: Therapeutic Potential of Estrogen
11	ClinicalTrials.gov (NCT00127075) POPART'MUS: Prevention of Post Partum Relapses With Progestin and Estradiol in Multiple Sclerosis
12	ClinicalTrials.gov (NCT05900895) Estradiol Plus Olaparib for Breast Cancer (PHOEBE)
13	ClinicalTrials.gov (NCT00001481) The Role of Hormones in Postpartum Mood Disorders
14	ClinicalTrials.gov (NCT04283656) Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women
15	ClinicalTrials.gov (NCT03479879) Estradiol Pretreatment With Misoprostol in Second Trimester Miscarriage
16	ClinicalTrials.gov (NCT01065220) Sex Steroids and the Serotonin Transporter