Details of the Drug Combinations

General Information of This Drug (ID: DMUR64T)

Drug Name

Lesinurad DMUR64T

Synonyms

LESINURAD; 878672-00-5; RDEA594; Zurampic; RDEA 594; UNII-09ERP08I3W; RDEA-594; 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetic acid; 09ERP08I3W; AK323774; C17H14BrN3O2S; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]acetic acid; 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid; 2-(5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Hyperuricaemia	5C55.Y	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Allopurinol + Lesinurad	DCGOBYG	Allopurinol	Gout	[2]
Febuxostat + Lesinurad	DCAX8DV	Febuxostat	Tophaceous Gout	[3]
Lesinurad + Naproxen	DCU646T	Naproxen	Gout	[4]
Lesinurad + Indomethacin	DCY25NE	Indomethacin	Gout	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7673).
2	ClinicalTrials.gov (NCT01510158) Combining Lesinurad With Allopurinol in Inadequate Responders
3	ClinicalTrials.gov (NCT01510769) Combination Treatment Study in Subjects With Tophaceous Gout With Lesinurad and Febuxostat
4	ClinicalTrials.gov (NCT01884272) NSAID Drug Interaction Study