Details of the Drug Combinations

General Information of This Drug (ID: DMUSZHD)

• Drug Name: Hydrochlorothiazide (DMUSZHD)
• Synonyms: Acesistem; Acuilix; Acuretic; Aldazida; Aldoril; Apresazide; Aquarills; Aquarius; Bremil; Briazide; Caplaril; Carozide; Catiazida; Chlorizide; Chlorosulthiadil; Chlorzide; Chlothia; Cidrex; Clorana; Condiuren; Diaqua; Dichlorosal; Dichlorotride; Dichlothiazide; Dichlotiazid; Dichlotride; Diclotride; Dicyclotride; Didral; Dihydran; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Dihydrochlorurit; Dihydrochlorurite; Dihydroxychlorothiazidum; Direma; Disalunil; Disothiazid; Diurogen; Dixidrasi; Drenol; Esidrex; Esidrix; Esoidrina; Fluvin; HCT; HCTZ; HCZ; Hidril; Hidrochlortiazid; Hidroclorotiazida; Hidroronol; Hidrosaluretil; Hidrotiazida; Hyclosid; Hydril; HydroDIURIL; Hydrochlorat; Hydrochlorot; Hydrochlorothiazid; Hydrochlorothiazidum; Hydrochlorthiazide; Hydrochlorthiazidum; Hydrocot; Hydrodiuretic; Hydropres; Hydrosaluric; Hydrothide; Hydrozide; Hypothiazid; Hypothiazide; Hytrid; Idroclorotiazide; Idrotiazide; Indroclor; Ivaugan; Manuril; Maschitt; Medozide; Megadiuril; Microzide; Mictrin; Mikorten; Modurcen; Moduretic; Natrinax; Nefrix; Nefrol; Neoflumen; Newtolide; Novodiurex; Oretic; Pantemon; Panurin; Roxane; Saldiuril; Sectrazide; Selozide; Servithiazid; Spironazide; Tandiur; Thiaretic; Thiuretic; Thlaretic; Timolide; Unazid; Urodiazin; Urozide; Vaseretic; Vetidrex; Aquazide H; Chlorsulfonamidodihydrobenzothiadiazine dioxide; Component of Aldactazide; Component of Aldoril; Component of Butizide Prestabs; Component of Caplaril; Component of Cyclex; Component of Dyazide; Component of Esimil; Concor Plus; Diclot ride; Hydro Par; Hydrochlorothiazide Intensol; Idroclorotiazide [DCIT]; Lotensin HCT; Panurin dichloride; Raunova Plus; Diu 25 Vigt; H 4759; MaybridgeCompound 10; Mazide 25 mg; Su 5879; Aldactazide 25/25; Aldectazide 50/50; Apo-Hydro; Aquazide H (TN); Aquazide-H; Dichlotride (TN); Diu-melusin; Esidrex (TN); Esidrix (TN); HCT-Isis; Hidro-Niagrin; Hidroclorotiazida [INN-Spanish]; Hydrex-semi; Hydro-Aquil; Hydro-D; Hydro-Diuril; Hydro-Saluric; Hydro-T; Hydro-chlor; HydroSaluric (TN); Hydrochlorothiazidum [INN-Latin]; Hydrodiuril (TN); Hydrozide Injection, Veterinary; Jen-Diril; Microzide (TN); Neo-Flumen; Neo-Minzil; Neo-codema; Oretic (TN); Ro-hydrazide; AF-614/30832002; Apo-Hydro (TN); Hydrochlorothiazide [INN:BAN:JAN]; Hydrochlorothiazide (JP15/USP/INN); Dro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi; 3,4-Dihydrochlorothiazide; 6-Chloro-7-sulfamoyl-3, 4-dihy

Indication

Chronic heart failure; ICD 11: BD1Z; Status: Approved [1]; Edema; ICD 11: MG29; Status: Approved [1]; Hypertension; ICD 11: BA00-BA04; Status: Approved [2]; Malignant essential hypertension; ICD 11: BA00; Status: Approved [1]; Prediabetes syndrome; ICD 11: N.A.; Status: Approved [1]

• Therapeutic Class: Diuretics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Hydrochlorothiazide + Panobinostat	DCMRHOP	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]

14 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aliskiren + Hydrochlorothiazide	DCN1VK5	Aliskiren	Cardiovascular Events	[4]
Aliskiren + Hydrochlorothiazide	DCRZNJ4	Aliskiren	Hypertension	[5]
Amlodipine + Hydrochlorothiazide	DCEPM00	Amlodipine	Hypertension	[6]
Candesartan + Hydrochlorothiazide	DC2X5XQ	Candesartan	Hypertension	[7]
Chlorthalidone + Hydrochlorothiazide	DCZ1Z5S	Chlorthalidone	Kidney Stones	[8]
Losartan + Hydrochlorothiazide	DCNS4JP	Losartan	Hypertension; Hypertrophy, Left Ventricular	[9]
Telmisartan + Hydrochlorothiazide	DC0UPA1	Telmisartan	Hypertension	[10]
Trandolapril + Hydrochlorothiazide	DCBYPSL	Trandolapril	Hypertension	[11]
Valsartan + Hydrochlorothiazide	DC4JNLS	Valsartan	Hypertension	[12]
Amiloride + Hydrochlorothiazide	DC7SOWJ	Amiloride	Chronic Kidney Disease	[13]
Dapagliflozin + Hydrochlorothiazide	DCCWLXX	Dapagliflozin	Urolithiasis	[14]
Furosemide + Hydrochlorothiazide	DC8VG3U	Furosemide	Heart Failure	[15]
Guanfacine + Hydrochlorothiazide	DC1BR0M	Guanfacine	Obstructive Sleep Apnea	[16]
Nebivolol + Hydrochlorothiazide	DC2AS4A	Nebivolol	Hypertension	[17]

References

• [1] Hydrochlorothiazide FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4836).
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] ClinicalTrials.gov (NCT01259297) A Randomized Controlled Trial of Aliskiren in the Prevention of Major Cardiovascular Events in Elderly People
• [5] ClinicalTrials.gov (NCT00787605) Aliskiren HCTZ Compared to Amlodipine in Patients With Stage 2 Systolic Hypertension and Diabetes Mellitus
• [6] ClinicalTrials.gov (NCT00649389) Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension
• [7] ClinicalTrials.gov (NCT00383929) Antihypertensive Efficacy and Safety of Candesartan/HCT 32/12.5 and 32/25 mg in Comparison With Candesartan 32 mg
• [8] ClinicalTrials.gov (NCT02711670) Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium
• [9] ClinicalTrials.gov (NCT00446563) Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy
• [10] ClinicalTrials.gov (NCT01050062) Post-Marketing Surveillance of Micombi Tablets Survey on the Long-term Use
• [11] ClinicalTrials.gov (NCT00887510) Metabolic Effects of Antihypertensive Drugs on People With Metabolic Syndrome (The MEAD Study)
• [12] ClinicalTrials.gov (NCT00171054) Efficacy and Safety of Valsartan Versus Amlodipine in Postmenopausal Women With Hypertension
• [13] ClinicalTrials.gov (NCT02875886) DD-study: Diet or Diuretics for Salt-sensitivity in Chronic Kidney Disease
• [14] ClinicalTrials.gov (NCT05443932) Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients
• [15] ClinicalTrials.gov (NCT03892148) Protocol of Diuretics Use in Congestive Therapy in Heart Failure
• [16] ClinicalTrials.gov (NCT02699125) Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic
• [17] ClinicalTrials.gov (NCT02710071) Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide