General Information of Drug (ID: DMUSZHD)

Drug Name
Hydrochlorothiazide
Synonyms
Acesistem; Acuilix; Acuretic; Aldazida; Aldoril; Apresazide; Aquarills; Aquarius; Bremil; Briazide; Caplaril; Carozide; Catiazida; Chlorizide; Chlorosulthiadil; Chlorzide; Chlothia; Cidrex; Clorana; Condiuren; Diaqua; Dichlorosal; Dichlorotride; Dichlothiazide; Dichlotiazid; Dichlotride; Diclotride; Dicyclotride; Didral; Dihydran; Dihydrochlorothiazid; Dihydrochlorothiazide; Dihydrochlorothiazidum; Dihydrochlorurit; Dihydrochlorurite; Dihydroxychlorothiazidum; Direma; Disalunil; Disothiazid; Diurogen; Dixidrasi; Drenol; Esidrex; Esidrix; Esoidrina; Fluvin; HCT; HCTZ; HCZ; Hidril; Hidrochlortiazid; Hidroclorotiazida; Hidroronol; Hidrosaluretil; Hidrotiazida; Hyclosid; Hydril; HydroDIURIL; Hydrochlorat; Hydrochlorot; Hydrochlorothiazid; Hydrochlorothiazidum; Hydrochlorthiazide; Hydrochlorthiazidum; Hydrocot; Hydrodiuretic; Hydropres; Hydrosaluric; Hydrothide; Hydrozide; Hypothiazid; Hypothiazide; Hytrid; Idroclorotiazide; Idrotiazide; Indroclor; Ivaugan; Manuril; Maschitt; Medozide; Megadiuril; Microzide; Mictrin; Mikorten; Modurcen; Moduretic; Natrinax; Nefrix; Nefrol; Neoflumen; Newtolide; Novodiurex; Oretic; Pantemon; Panurin; Roxane; Saldiuril; Sectrazide; Selozide; Servithiazid; Spironazide; Tandiur; Thiaretic; Thiuretic; Thlaretic; Timolide; Unazid; Urodiazin; Urozide; Vaseretic; Vetidrex; Aquazide H; Chlorsulfonamidodihydrobenzothiadiazine dioxide; Component of Aldactazide; Component of Aldoril; Component of Butizide Prestabs; Component of Caplaril; Component of Cyclex; Component of Dyazide; Component of Esimil; Concor Plus; Diclot ride; Hydro Par; Hydrochlorothiazide Intensol; Idroclorotiazide [DCIT]; Lotensin HCT; Panurin dichloride; Raunova Plus; Diu 25 Vigt; H 4759; MaybridgeCompound 10; Mazide 25 mg; Su 5879; Aldactazide 25/25; Aldectazide 50/50; Apo-Hydro; Aquazide H (TN); Aquazide-H; Dichlotride (TN); Diu-melusin; Esidrex (TN); Esidrix (TN); HCT-Isis; Hidro-Niagrin; Hidroclorotiazida [INN-Spanish]; Hydrex-semi; Hydro-Aquil; Hydro-D; Hydro-Diuril; Hydro-Saluric; Hydro-T; Hydro-chlor; HydroSaluric (TN); Hydrochlorothiazidum [INN-Latin]; Hydrodiuril (TN); Hydrozide Injection, Veterinary; Jen-Diril; Microzide (TN); Neo-Flumen; Neo-Minzil; Neo-codema; Oretic (TN); Ro-hydrazide; AF-614/30832002; Apo-Hydro (TN); Hydrochlorothiazide [INN:BAN:JAN]; Hydrochlorothiazide (JP15/USP/INN); Dro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi; 3,4-Dihydrochlorothiazide; 6-Chloro-7-sulfamoyl-3, 4-dihy
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Edema MG29 Approved [1]
Hypertension BA00-BA04 Approved [2]
Malignant essential hypertension BA00 Approved [1]
Prediabetes syndrome N.A. Approved [1]
Therapeutic Class
Diuretics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 297.7
Logarithm of the Partition Coefficient (xlogp) -0.1
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 7
ADMET Property
Absorption Cmax
The maximum plasma concentration (Cmax) of drug is 70-490 mcg/L [3]
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1-5 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [4]
Bioavailability
The bioavailability of drug is 65-75% [3]
Clearance
The renal clearance of drug is 285 mL/min [5]
Elimination
100% of drug is excreted from urine in the unchanged form [4]
Half-life
The concentration or amount of drug in body reduced by one-half in 5.6 - 14.8 hours [6]
Metabolism
The drug is not metabolised [6]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 11.18424 micromolar/kg/day [7]
Vd
The volume of distribution (Vd) of drug is 0.83-4.19 L/kg [8]
Water Solubility
The ability of drug to dissolve in water is measured as 0.6 mg/mL [4]
Adverse Drug Reaction (ADR)
ADR Term Variation Related DOT DOT ID REF
Poisoning and toxicity Not Available CYP2D6 OTZJC802 [9]
Sudden cardiac death Not Available KCNQ1 OT8SPJNX [9]
Sudden cardiac death Not Available SCN5A OTGYZWR6 [9]
Sudden cardiac death Not Available KCNH2 OTZX881H [9]
Urinary abnormalities Not Available PTGER1 OTZV8W66 [9]
Chemical Identifiers
Formula
C7H8ClN3O4S2
IUPAC Name
6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Canonical SMILES
C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
InChI
InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKey
JZUFKLXOESDKRF-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
3639
ChEBI ID
CHEBI:5778
CAS Number
58-93-5
DrugBank ID
DB00999
TTD ID
D0U4UQ
VARIDT ID
DR00460
ACDINA ID
D00312
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Angiotensin-converting enzyme (ACE) TTL69WB ACE_HUMAN Modulator [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [11]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Drug Response [9]
HLA class I histocompatibility antigen, alpha chain E (HLA-E) OTX1CTFB HLAE_HUMAN Gene/Protein Processing [12]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Gene/Protein Processing [12]
HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1) OT7OG7Y2 DPA1_HUMAN Gene/Protein Processing [12]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1) OTRGGIFP DRB1_HUMAN Gene/Protein Processing [12]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Gene/Protein Processing [12]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Drug Response [9]
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1) OT8SPJNX KCNQ1_HUMAN Drug Response [9]
Prostaglandin E2 receptor EP1 subtype (PTGER1) OTZV8W66 PE2R1_CANLF Drug Response [9]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Chronic heart failure
ICD Disease Classification BD1Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Angiotensin-converting enzyme (ACE) DTT SLC33A1 2.62E-01 -0.01 -0.06
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Hydrochlorothiazide
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Acebutolol DM0TI4U Moderate Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Acebutolol. Hypertension [BA00-BA04] [13]
Captopril DM458UM Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Captopril. Hypertension [BA00-BA04] [14]
Nebivolol DM7F1PA Moderate Increased risk of hyperglycemia by the combination of Hydrochlorothiazide and Nebivolol. Hypertension [BA00-BA04] [13]
Coadministration of a Drug Treating the Disease Different from Hydrochlorothiazide (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Dronedarone DMA8FS5 Major Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Dronedarone. Angina pectoris [BA40] [15]
Rabeprazole DMMZXIW Moderate Increased risk of hypomagnesemia by the combination of Hydrochlorothiazide and Rabeprazole. Bacterial infection [1A00-1C4Z] [16]
Cariprazine DMJYDVK Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Cariprazine. Bipolar disorder [6A60] [17]
Ketoprofen DMRKXPT Moderate Antagonize the effect of Hydrochlorothiazide when combined with Ketoprofen. Chronic pain [MG30] [18]
Levomilnacipran DMV26S8 Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Levomilnacipran. Chronic pain [MG30] [19]
Sertraline DM0FB1J Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Sertraline. Depression [6A70-6A7Z] [19]
Vilazodone DM4LECQ Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Vilazodone. Depression [6A70-6A7Z] [19]
Selegiline DM6034S Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Selegiline. Depression [6A70-6A7Z] [20]
Vortioxetine DM6F1PU Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Vortioxetine. Depression [6A70-6A7Z] [19]
Isocarboxazid DMAF1NB Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Isocarboxazid. Depression [6A70-6A7Z] [20]
Milnacipran DMBFE74 Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Milnacipran. Depression [6A70-6A7Z] [19]
Escitalopram DMFK9HG Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Escitalopram. Depression [6A70-6A7Z] [19]
Desvenlafaxine DMHD4PE Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Desvenlafaxine. Depression [6A70-6A7Z] [19]
OPC-34712 DMHG57U Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and OPC-34712. Depression [6A70-6A7Z] [17]
Mepenzolate DM8YU2F Minor Altered absorption of Hydrochlorothiazide due to GI dynamics variation caused by Mepenzolate. Digestive system disease [DE2Z] [21]
Oxybutynine DMJPBAX Minor Altered absorption of Hydrochlorothiazide due to GI dynamics variation caused by Oxybutynine. Discovery agent [N.A.] [21]
Eslicarbazepine DMZREFQ Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Eslicarbazepine. Epilepsy/seizure [8A61-8A6Z] [22]
Nadolol DMW6GVL Moderate Increased risk of hypertriglyceridemia by the combination of Hydrochlorothiazide and Nadolol. Essential hypertension [BA00] [13]
Solifenacin DMG592Q Minor Altered absorption of Hydrochlorothiazide due to GI dynamics variation caused by Solifenacin. Functional bladder disorder [GC50] [21]
Tolterodine DMSHPW8 Minor Altered absorption of Hydrochlorothiazide due to GI dynamics variation caused by Tolterodine. Functional bladder disorder [GC50] [21]
Dexlansoprazole DM1DBV5 Moderate Increased risk of hypomagnesemia by the combination of Hydrochlorothiazide and Dexlansoprazole. Gastro-oesophageal reflux disease [DA22] [16]
Levobunolol DMTNFCQ Moderate Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Levobunolol. Glaucoma [9C61] [13]
Carvedilol DMHTEAO Moderate Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Carvedilol. Heart failure [BD10-BD1Z] [13]
Digitoxin DMWVIGP Moderate Increased risk of hypomagnesemia by the combination of Hydrochlorothiazide and Digitoxin. Heart failure [BD10-BD1Z] [23]
Procarbazine DMIK367 Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Procarbazine. Hodgkin lymphoma [2B30] [20]
Belladonna DM2RBWK Minor Altered absorption of Hydrochlorothiazide due to GI dynamics variation caused by Belladonna. Infectious gastroenteritis/colitis [1A40] [21]
ITI-007 DMUQ1DO Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and ITI-007. Insomnia [7A00-7A0Z] [17]
Arsenic trioxide DM61TA4 Major Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Arsenic trioxide. Mature B-cell lymphoma [2A85] [24]
Ozanimod DMT6AM2 Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Ozanimod. Multiple sclerosis [8A40] [20]
Promethazine DM6I5GR Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Promethazine. Nausea/vomiting [MD90] [17]
Sibutramine DMFJTDI Moderate Increased risk of hyponatremia by the combination of Hydrochlorothiazide and Sibutramine. Obesity [5B80-5B81] [19]
Levomethadyl Acetate DM06HG5 Major Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Levomethadyl Acetate. Opioid use disorder [6C43] [25]
Flavoxate DMKV4NL Minor Altered absorption of Hydrochlorothiazide due to GI dynamics variation caused by Flavoxate. Pain [MG30-MG3Z] [21]
Rasagiline DM3WKQ4 Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Rasagiline. Parkinsonism [8A00] [20]
Levomepromazine DMIKFEL Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Levomepromazine. Psychotic disorder [6A20-6A25] [17]
Quetiapine DM1N62C Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Quetiapine. Schizophrenia [6A20] [17]
Aripiprazole DM3NUMH Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Aripiprazole. Schizophrenia [6A20] [17]
Iloperidone DM6AUFY Moderate Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Iloperidone. Schizophrenia [6A20] [26]
Paliperidone DM7NPJS Moderate Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Paliperidone. Schizophrenia [6A20] [26]
Molindone DMAH70G Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Molindone. Schizophrenia [6A20] [17]
Thiothixene DMDINC4 Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Thiothixene. Schizophrenia [6A20] [17]
Amisulpride DMSJVAM Moderate Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Amisulpride. Schizophrenia [6A20] [26]
Pimozide DMW83TP Major Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Pimozide. Schizophrenia [6A20] [27]
Trimeprazine DMEMV9D Moderate Additive hypotensive effects by the combination of Hydrochlorothiazide and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [28]
Amiodarone DMUTEX3 Major Increased risk of ventricular arrhythmias by the combination of Hydrochlorothiazide and Amiodarone. Ventricular tachyarrhythmia [BC71] [29]
⏷ Show the Full List of 45 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Allura red AC dye E00338 33258 Colorant
D&C red no. 28 E00491 6097185 Colorant
Docusate sodium E00563 23673837 Surfactant
FD&C blue no. 1 E00263 19700 Colorant
FD&C blue no. 2 E00446 2723854 Colorant
Quinoline yellow WS E00309 24671 Colorant
Sodium benzoate E00432 517055 Antimicrobial preservative; lubricant
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Stearic acid E00079 5281 Emulsifying agent; Solubilizing agent; Viscosity-controlling agent; lubricant
Sunset yellow FCF E00255 17730 Colorant
Beta-D-lactose E00099 6134 Diluent; Dry powder inhaler carrier; Lyophilization aid
Brushite E00392 104805 Diluent
Butyl alcohol E00011 263 Flavoring agent; Solvent
Calcium hydrogenphosphate E00294 24441 Diluent
Calcium stearate E00244 15324 lubricant
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
⏷ Show the Full List of 24 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Hydrochlorothiazide 12.5 mg capsule 12.5 mg Oral Capsule Oral
Hydrochlorothiazide 12.5 mg tablet 12.5 mg Oral Tablet Oral
Hydrochlorothiazide 25 mg tablet 25 mg Oral Tablet Oral
Hydrochlorothiazide 50 mg tablet 50 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

1 Hydrochlorothiazide FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4836).
3 FDA Approved Drug Products: Hydrochlorothiazide Oral Capsules
4 BDDCS applied to over 900 drugs
5 Niemeyer C, Hasenfuss G, Wais U, Knauf H, Schafer-Korting M, Mutschler E: Pharmacokinetics of hydrochlorothiazide in relation to renal function. Eur J Clin Pharmacol. 1983;24(5):661-5. doi: 10.1007/bf00542218.
6 FDA Approved Drug Products: Hydrochlorothiazide Oral Tablets
7 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
8 Chen TM, Chiou WL: Large differences in the biological half-life and volume of distribution of hydrochlorothiazide in normal subjects from eleven studies. Correlation with their last blood sampling times. Int J Clin Pharmacol Ther Toxicol. 1992 Jan;30(1):34-7.
9 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
10 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
11 Multichannel liquid chromatography-tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm Res. 2007 Dec;24(12):2281-96.
12 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
13 Dean S, Kendall MJ, Potter S, Thompson MH, Jackson DA "Nadolol in combination with indapamide and xipamide in resistant hypertensives." Eur J Clin Pharmacol 28 (1985): 29-33. [PMID: 3987783]
14 Burnakis TG, Mioduch HJ "Combined therapy with captopril and potassium supplementation: a potential for hyperkalemia." Arch Intern Med 144 (1984): 2371-2. [PMID: 6391404]
15 Product Information. Multaq (dronedarone). sanofi-aventis , Bridgewater, NJ.
16 FDA. U.S. Food and Drug Administration "FDA Drug Safety Communication: Low magnesium levels can be associated with long-term use of proton pump inhibitor drugs (PPIs).".
17 Aronowitz JS, Chakos MH, Safferman AZ, Lieberman JA "Syncope associated with the combination of clozapine and enalapril." J Clin Psychopharmacol 14 (1994): 429-30. [PMID: 7884028]
18 McCarthy JT, Torres VE, Romero JC, et al "Acute intrinsic renal failure induced by indomethacin." Mayo Clin Proc 57 (1982): 289-96. [PMID: 6952058]
19 Product Information. Savella (milnacipran). Forest Pharmaceuticals, St. Louis, MO.
20 Ban TA "Drug interactions with psychoactive drugs." Dis Nerv Syst 36 (1975): 164-6. [PMID: 1116424]
21 Beermann B, Groschinsky-Grind M "Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline." Eur J Clin Pharmacol 13 (1978): 385-7. [PMID: 668798]
22 Product Information. Aptiom (eslicarbazepine). Sunovion Pharmaceuticals Inc, Marlborough, MA.
23 Brown DD, Dormois JC, Abraham GN, et al "Effect of furosemide on the renal excretion of digoxin." Clin Pharmacol Ther 20 (1976): 395-400. [PMID: 975715]
24 Ohnishi K, Yoshida H, Shigeno K, et al. "Prolongation of the QT interval and ventricular tachycardia in patients treated with arsenic trioxide for acute promyelocytic leukemia." Ann Intern Med 133 (2000): 881-5. [PMID: 11103058]
25 Cohen J "Long-term efficacy and safety of terazosin alone and in combination with other antihypertensive agents." Am Heart J 122 (1991): 919-25. [PMID: 1678923]
26 Cerner Multum, Inc. "Australian Product Information.".
27 Product Information. Orap Tablets (pimozide). Gate Pharmaceuticals, Sellersville, PA.
28 Product Information. Clozaril (clozapine). Novartis Pharmaceuticals, East Hanover, NJ.
29 Antonelli D, Atar S, Freedberg NA, Rosenfeld T "Torsade de pointes in patients on chronic amiodarone treatment: contributing factors and drug interactions." Isr Med Assoc J 7 (2005): 163-5. [PMID: 15792261]