General Information of This Drug (ID: DMUYKBZ)

Drug Name
Cyclosporin A   DMUYKBZ
Synonyms cyclosporin A; cyclosporine; Neoral; Cyclosporin; Ciclosporine; Sandimmun; Sang-35
Indication
Disease Entry ICD 11 Status REF
Adult acute monocytic leukemia N.A. Approved [1]
Bronchiolitis obliterans syndrome N.A. Approved [2]
Large granular lymphocytic leukemia 2A90.1 Approved [3]
Leukemia N.A. Approved [4]
Lupus nephritis 4A40.0Y Approved [5]
Myeloid leukaemia 2B33.1 Approved [6]
Psoriasis EA90 Approved [7]
Xerophthalmia 5B55.Y Approved [8]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1 [9]
Corneal disease 9A78.Z Investigative [10]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Artemisinin + Cyclosporin A DCBMOE7 Artemisinin DD2 (Cell Line: DD2) [11]
Atovaquone + Cyclosporin A DCME91O Atovaquone DD2 (Cell Line: DD2) [11]
Cyclosporin A + Marizomib DCVFZJP Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [11]
Cyclosporin A + Idarubicin DCAATS9 Idarubicin Glioblastoma? (Cell Line: T98G) [11]
Lumefantrine + Cyclosporin A DCBSRNF Lumefantrine DD2 (Cell Line: DD2) [11]
Lumefantrine + Cyclosporin A DC9U1KA Lumefantrine Hepatoblastoma (Cell Line: HB3) [11]
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⏷ Show the Full List of 6 DrugCom(s)
34 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Apixaban + Cyclosporin A DCQY312 Apixaban Venous Thromboembolism [12]
Azathioprine + Cyclosporin A DC462NP Azathioprine Mucopolysaccharidosis I [13]
Cyclophosphamide + Cyclosporin A DCIJ8RT Cyclophosphamide Aplastic Anemia [14]
Cyclophosphamide + Cyclosporin A DC0J5JV Cyclophosphamide Acute Myelogenous Leukemia [15]
Cyclosporin A + Tacrolimus DC516KQ Tacrolimus Skin Cancer [16]
Cyclosporin A + Tacrolimus DC9ZTCF Tacrolimus End-Stage Renal Disease [17]
Cyclosporin A + Dasatinib DCEEZBO Dasatinib Accelerated Phase Chronic Myelogenous Leukemia [18]
Cyclosporin A + Colchicine DCHKNIH Colchicine Pharmacokinetics [19]
Decitabine + Cyclosporin A DCGEUUC Decitabine Leukemia [20]
Everolimus + Cyclosporin A DC43PBW Everolimus Kidney Transplantation [21]
Everolimus + Cyclosporin A DCJVUA2 Everolimus Kidney Dysfunction [22]
Ezetimibe + Cyclosporin A DCA0W7I Ezetimibe Cholesterol [23]
F901318 + Cyclosporin A DCZKJWP F901318 Invasive Aspergillosis [24]
Hydrocortisone + Cyclosporin A DC6OG7M Hydrocortisone Dry Eye Syndromes [25]
Irinotecan + Cyclosporin A DC7IZS3 Irinotecan Drug/Agent Toxicity by Tissue/Organ [26]
Lenalidomide + Cyclosporin A DCESXKJ Lenalidomide Myelodysplastic Syndrome [27]
Methotrexate + Cyclosporin A DCK7VO5 Methotrexate Graft vs Host Disease [28]
Methotrexate + Cyclosporin A DCNO2DZ Methotrexate Neoplasm Metastasis [29]
Mycophenolate mofetil + Cyclosporin A DC6CQ1B Mycophenolate mofetil Accelerated Phase Chronic Myelogenous Leukemia [30]
Mycophenolate mofetil + Cyclosporin A DCMN5XC Mycophenolate mofetil Acute Myeloid Leukemia/Transient Myeloproliferative Disorder [31]
Mycophenolate mofetil + Cyclosporin A DC6PKR5 Mycophenolate mofetil Kidney Dysfunction [22]
Mycophenolate mofetil + Cyclosporin A DCUQUC3 Mycophenolate mofetil Adenosine Deaminase Deficiency [32]
Mycophenolate mofetil + Cyclosporin A DC1564L Mycophenolate mofetil Adult Acute Myeloid Leukemia in Remission [33]
Mycophenolate mofetil + Cyclosporin A DCUTAIB Mycophenolate mofetil Recurrent Renal Cell Cancer [34]
Prednisolone + Cyclosporin A DCMINDQ Prednisolone Lupus Nephritis [35]
Telaprevir + Cyclosporin A DCDSQM9 Telaprevir Hepatitis C [36]
Cyclophosphamide + Cyclosporin A DCV8IFB Cyclophosphamide Chronic Granulomatous Disease [37]
Cyclophosphamide + Cyclosporin A DCI2UFM Cyclophosphamide Chronic Myelogenous Leukemia [38]
Methotrexate + Cyclosporin A DCB7FI1 Methotrexate Accelerated Phase Chronic Myelogenous Leukemia [39]
Mycophenolate mofetil + Cyclosporin A DCZHK3W Mycophenolate mofetil Dyskeratosis Congenita [40]
Mycophenolate mofetil + Cyclosporin A DCXMKNG Mycophenolate mofetil Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities [41]
Mycophenolic acid + Cyclosporin A DCBKV33 Mycophenolic acid Acute Myeloid Leukemia (AML) [42]
Mycophenolate mofetil + Cyclosporin A DC66M1D Mycophenolate mofetil Kidney Transplantation [43]
Mycophenolate mofetil + Cyclosporin A DCNKNWM Mycophenolate mofetil Liver Transplantation [44]
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⏷ Show the Full List of 34 DrugCom(s)

References

1 Clinical and biological impact of ATP-binding cassette transporter activity in adult acute myeloid leukemia. Haematologica. 2023 Jan 1;108(1):61-68.
2 Bronchiolitis obliterans syndrome is associated with increased senescent lymphocytes in the small airways. J Heart Lung Transplant. 2021 Feb;40(2):108-119.
3 Rituximab for rheumatoid arthritis-associated large granular lymphocytic leukemia, a retrospective case series. Semin Arthritis Rheum. 2020 Oct;50(5):1109-1113.
4 Cyclosporin A protects JEG-3 cells against oxidative stress-induced apoptosis by inhibiting the p53 and JNK/p38 signaling pathways. Reprod Biol Endocrinol. 2020 Oct 12;18(1):100.
5 Efficacy and safety of Iguratimod as an add-on therapy for refractory lupus nephritis: A preliminary investigational study. Front Immunol. 2023 Mar 8;14:1062919.
6 Efficacy and safety of extended duration letermovir prophylaxis in recipients of haematopoietic stem-cell transplantation at risk of cytomegalovirus infection: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Haematol. 2024 Feb;11(2):e127-e135.
7 Pustular psoriasis. Cutis. 1993 Jan;51(1):29-32.
8 Cyclosporin A (CyA) in primary Sj?gren's syndrome: a double blind study. Ann Rheum Dis. 1986 Sep;45(9):732-5.
9 Why Choose Cyclosporin A as First-line Therapy in COVID-19 Pneumonia. Reumatol Clin. 2020 Apr 16;S1699-258X(20)30044-9.
10 Anti-inflammatory therapy of dry eye. Ocul Surf. 2003 Jan;1(1):31-6.
11 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
12 ClinicalTrials.gov (NCT03083782) Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus
13 ClinicalTrials.gov (NCT00741338) Immune Tolerance Study With Aldurazyme (Laronidase)
14 ClinicalTrials.gov (NCT01193283) Cyclophosphamide Plus Cyclosporine in Treatment-Naive Severe Aplastic Anemia
15 ClinicalTrials.gov (NCT00303667) Donor Natural Killer Cells and Aldesleukin in Treating Patients w/High Risk AML Undergoing Donor Stem Cell Transplant
16 ClinicalTrials.gov (NCT00133887) TUMORAPA 1: Efficacy of Rapamycin in Secondary Prevention of Skin Cancers in Kidney Transplant Recipients
17 ClinicalTrials.gov (NCT00005113) A Study to Compare Treatment With Sirolimus Versus Standard Treatment in Patients Who Have Received a Kidney Transplant
18 ClinicalTrials.gov (NCT01426334) Dasatinib and Cyclosporine in Treating Patients With Chronic Myelogenous Leukemia Refractory or Intolerant to Imatinib Mesylate
19 ClinicalTrials.gov (NCT00983931) Drug-Drug Interaction Study Between Colchicine and Cyclosporine
20 ClinicalTrials.gov (NCT00002832) Decitabine and Peripheral Stem Cell Transplantation in Treating Patients Who Have Relapsed Following Bone Marrow Transplantation for Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia
21 ClinicalTrials.gov (NCT00514514) Study Investigating a Standard Regimen in de Novo Kidney Transplant Patients Versus a Calcineurin Inhibitor (CNI)-Free Regimen and a CNI-low Dose Regimen
22 ClinicalTrials.gov (NCT00420537) Shift to Everolimus (RAD) Kidney Sparing Study
23 ClinicalTrials.gov (NCT00653276) MD Ezetimibe Cyclosporine Interaction (0653-057)
24 ClinicalTrials.gov (NCT03095547) Drug/Drug Interactions With F901318
25 ClinicalTrials.gov (NCT04597762) Effect of Ciclosporin Eyedrops on Sjgren Syndrome
26 ClinicalTrials.gov (NCT00002759) Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma
27 ClinicalTrials.gov (NCT00840827) Efficacy and Safety of Lenalidomide in Combination With Cyclosporine A in Patients With Myelodysplastic Syndromes
28 ClinicalTrials.gov (NCT01788501) Tacrolimus/Methotrexate Versus Cyclosporine/Methotrexate for Prophylaxis of Graft Versus Host Disease
29 ClinicalTrials.gov (NCT00001880) Stem Cell Transplantation for Metastatic Solid Tumors
30 ClinicalTrials.gov (NCT00005799) Fludarabine Phosphate, Low-Dose Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies or Kidney Cancer
31 ClinicalTrials.gov (NCT00014235) Fludarabine Phosphate and Total-Body Radiation Followed by Donor Peripheral Blood Stem Cell Transplant and Immunosuppression in Treating Patients With Hematologic Malignancies
32 ClinicalTrials.gov (NCT00008450) Total-Body Irradiation Followed By Cyclosporine and Mycophenolate Mofetil in Treating Patients With Severe Combined Immunodeficiency Undergoing Donor Bone Marrow Transplant
33 ClinicalTrials.gov (NCT00008177) Radiolabeled Monoclonal Antibody Therapy, Fludarabine Phosphate, and Low-Dose Total-Body Irradiation Followed by Donor Stem Cell Transplant and Immunosuppression Therapy in Treating Older Patients With Advanced Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndromes
34 ClinicalTrials.gov (NCT00005851) Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed By Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Stage IV Kidney Cancer
35 ClinicalTrials.gov (NCT03791827) Multicenter Registry of Pediatric Lupus Nephritis in China
36 ClinicalTrials.gov (NCT01038167) A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults
37 ClinicalTrials.gov (NCT00578643) Matched Unrelated or Non-Genotype Identical Related Donor Transplantation For Chronic Granulomatous Disease
38 ClinicalTrials.gov (NCT00378534) Methods to Enhance the Safety and Effectiveness of Stem Cell Transplants
39 ClinicalTrials.gov (NCT01789255) Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological Malignancies
40 ClinicalTrials.gov (NCT01659606) Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita
41 ClinicalTrials.gov (NCT00040846) Alemtuzumab, Fludarabine Phosphate, and Low-Dose Total Body Irradiation Before Donor Stem Cell Transplantation in Treating Patients With Hematological Malignancies
42 ClinicalTrials.gov (NCT02416388) Study to Improve OS in 18 to 60 Year-old Patients, Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens, High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens, and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR
43 ClinicalTrials.gov (NCT00087581) Study of Therapeutic Monitoring of Mycophenolate Mofetil (MMF/CellCept) After Kidney Transplantation
44 ClinicalTrials.gov (NCT00118742) Liver Spare the Nephron (STN) Study - A Study of CellCept (Mycophenolate Mofetil) and Sirolimus in Recipients of a Liver Transplant