Details of the Drug Combinations

General Information of This Drug (ID: DMV23GL)

Drug Name

LIDOFLAZINE DMV23GL

Synonyms

LIDOFLAZINE; Ordiflazine; Corflazine; Clinium; Lidoflazinum; Lidoflazin; 3416-26-0; Klinium; Angex; Lidoflazina [Italian]; McN-JR 7904; UNII-J4ZHN3HBTE; Lidoflazinum [INN-Latin]; Lidoflazina [INN-Spanish]; Lidoflazine [USAN:INN:BAN]; C30H35F2N3O; J4ZHN3HBTE; EINECS 222-312-8; R 7904; BRN 0904339; CHEMBL92870; MCN-JR-7904; 4-(4,4-Bis(p-fluorophenyl)butyl)-1-piperazineaceto-2',6'-xylidide; 1-Piperazineacetamide, 4-(4,4-bis(4-fluorophenyl)butyl)-N-(2,6-dimethylphenyl)-; NCGC00016627-01; NCGC00016627-04; CAS-3416-26-0

Indication

Disease Entry	ICD 11	Status	REF
Angina pectoris	BA40	Approved	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

8 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Chloroquine + Lidoflazine	DCM91G3	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[2]
Lidoflazine + Lumefantrine	DCP0K0L	Lumefantrine	DD2 (Cell Line: DD2)	[2]
Lidoflazine + Idarubicin	DCTQPZW	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
Lidoflazine + Piperaquine	DCSY42P	Piperaquine	DD2 (Cell Line: DD2)	[2]
Lidoflazine + Mefloquine	DC7RHOA	Mefloquine	DD2 (Cell Line: DD2)	[2]
Lidoflazine + Lumefantrine	DCH6XBJ	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Lidoflazine + Chloroquine	DCU9LSZ	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[3]
Lidoflazine + Mefloquine	DC89FCR	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 8 DrugCom(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.