Details of the Drug Combinations

General Information of This Drug (ID: DMVIMQX)

Drug Name

ZSTK474 DMVIMQX

Synonyms

ZSTK474; 475110-96-4; ZSTK-474; 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine; ZSTK 474; TCMDC-137004; UNII-K0068GK39A; CHEMBL586702; CHEBI:90545; K0068GK39A; 2-(2-difluoromethylbenzimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine; 2-(2-Difluoromethylbenzimidazol-1-yl)-4,6-bis(morpholino)-1,3,5-triazine; AK-40326; 2-(Difluoromethyl)-1-(4,6-Dimorpholin-4-Yl-1,3,5-Triazin-2-Yl)-1h-Benzimidazole; C19H21F2N7O2; 2wxl; PubChem22461; SCHEMBL373282; QCR-72; GTPL7965; CTK8B6247; SYN1099

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Alvespimycin hydrochloride + ZSTK474	DCBS7DU	Alvespimycin hydrochloride	Hepatoblastoma (Cell Line: HB3)	[2]
GDC-0084 + ZSTK474	DC3B96O	GDC-0084	DD2 (Cell Line: DD2)	[3]
Torin 1 + ZSTK474	DCAVKY1	Torin 1	DD2 (Cell Line: DD2)	[3]
ZSTK474 + Ruxolitinib	DC7W956	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
ZSTK474 + Doxycycline	DCNON88	Doxycycline	Hepatoblastoma (Cell Line: HB3)	[3]
ZSTK474 + Chloroquine	DC7VRXV	Chloroquine	DD2 (Cell Line: DD2)	[3]
ZSTK474 + Chloroquine	DCI4T95	Chloroquine	Hepatoblastoma (Cell Line: HB3)	[3]
ZSTK474 + Quinine	DC28M9K	Quinine	DD2 (Cell Line: DD2)	[3]
ZSTK474 + Quinine	DC892SW	Quinine	Hepatoblastoma (Cell Line: HB3)	[3]
ZSTK474 + Nitisinone	DCG6JM9	Nitisinone	DD2 (Cell Line: DD2)	[3]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7965).
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.