Details of the Drug Combinations

General Information of This Drug (ID: DMWVH62)

Drug Name
SCH772984   DMWVH62
Synonyms SCH-772984
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

30 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BGJ398 + SCH772984 DC5HG07 BGJ398 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
BGJ398 + SCH772984 DCFRLD9 BGJ398 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
BGJ398 + SCH772984 DCGIJAR BGJ398 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
Everolimus + SCH772984 DCHKL54 Everolimus Embryonal rhabdomyosarcoma (Cell Line: Rh36) [3]
Everolimus + SCH772984 DC723LF Everolimus Embryonal rhabdomyosarcoma (Cell Line: CTR) [3]
Everolimus + SCH772984 DCIFOET Everolimus Embryonal rhabdomyosarcoma (Cell Line: RD) [3]
SCH772984 + Panobinostat DCREGIG Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
SCH772984 + Trametinib DCQF7KH Trametinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + Trametinib DCQWBN9 Trametinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + JQ1 DCRE1S2 JQ1 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + JQ1 DCBTTPJ JQ1 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + JQ1 DC3TIFI JQ1 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + Belinostat DCBIAM8 Belinostat Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + Belinostat DCFFUMP Belinostat Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + PMID25656651-Compound-5 DCAFRKO PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + PMID25656651-Compound-5 DCQP06W PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + PMID25656651-Compound-5 DCMF3GZ PMID25656651-Compound-5 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + Ceritinib DC4AXJX Ceritinib Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + Ceritinib DC8CEXO Ceritinib Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + Ceritinib DCL2N4F Ceritinib Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + GSK2126458 DCBXNDC GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + GSK2126458 DCH0KG2 GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + GSK2126458 DCDGF1E GSK2126458 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + BMS-754807 DCGOX4N BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + BMS-754807 DCPNVDS BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + BMS-754807 DCJDGPY BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + MK-2206 DCTDYR2 MK-2206 Embryonal rhabdomyosarcoma (Cell Line: Rh36) [2]
SCH772984 + MK-2206 DCYVENI MK-2206 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
SCH772984 + MK-2206 DCGQHI7 MK-2206 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
SCH772984 + SCH772984 DCPQ7LW SCH772984 Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
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⏷ Show the Full List of 30 DrugCom(s)

References

1 Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors. Cancer Discov. 2013 Jul;3(7):742-50.
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.