Details of the Drug Combinations

General Information of This Drug (ID: DMYILBE)

Drug Name

Modafinil DMYILBE

Synonyms

Provigil; Modiodal

Indication

Disease Entry	ICD 11	Status	REF
Malignant glioma	2A00.0	Approved	[1]
Methamphetamine dependence	6C46.2	Approved	[1]
Narcolepsy	7A20	Approved	[2]
Pain	MG30-MG3Z	Approved	[1]
Postpoliomyelitis syndrome	N.A.	Approved	[1]
Traumatic brain injury	NA07.Z	Approved	[1]
Bipolar disorder	6A60	Phase 4	[3]
Brain injury	NA07.Z	Investigative	[4]
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Therapeutic Class

Neurology Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dextroamphetamine + Modafinil	DC7X5RP	Dextroamphetamine	Cocaine-Related Disorders	[5]
Docetaxel + Modafinil	DCVU12W	Docetaxel	Prostatic Neoplasms	[6]
Ketamine + Modafinil	DCJZ2G6	Ketamine	Cognitive Symptom	[7]
Methadone + Modafinil	DC8KO1I	Methadone	Cocaine Dependence	[8]
Naltrexone + Modafinil	DCAUHEP	Naltrexone	Alcohol-Related Disorders	[9]
Propranolol + Modafinil	DCNSVIM	Propranolol	Postural Tachycardia Syndrome	[10]
Sodium oxybate + Modafinil	DCFZYYJ	Sodium oxybate	Narcolepsy	[11]
Aripiprazole + Modafinil	DCKZC2D	Aripiprazole	Schizophrenia	[12]
Risperidone + Modafinil	DCD05ZL	Risperidone	Schizophrenia	[12]
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References

1	Modafinil FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	ClinicalTrials.gov (NCT01965925) Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil. U.S. National Institutes of Health.
4	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
5	ClinicalTrials.gov (NCT00218062) Effectiveness of Modafinil and D-amphetamine in Treating Cocaine Dependent Individuals
6	ClinicalTrials.gov (NCT00917748) Study With Modafinil in Patients Treated With Docetaxel-Based Chemotherapy for Metastatic Breast or Prostate Cancer (MOTIF)
7	ClinicalTrials.gov (NCT03469089) Touchscreen-based Cognitive Tests in Healthy Volunteers
8	ClinicalTrials.gov (NCT00838981) Pharmacotherapy & CM for Opioid and Cocaine Dependence
9	ClinicalTrials.gov (NCT00142818) Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence
10	ClinicalTrials.gov (NCT01988883) Modafinil and Cognitive Function in POTS
11	ClinicalTrials.gov (NCT00066170) Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy
12	ClinicalTrials.gov (NCT01913327) Antipsychotic Effects on Brain Function in Schizophrenia