Details of the Drug Combination

General Information of Drug Combination (ID: DCFZYYJ)

Drug Combination Name
Sodium oxybate Modafinil
Indication
Disease Entry Status REF
Narcolepsy Phase 1 [1]
Component Drugs Sodium oxybate   DMBOV5P Modafinil   DMYILBE
Small molecule Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Sodium oxybate
Disease Entry ICD 11 Status REF
Narcolepsy 7A20 Approved [2]
Narcolepsy type 1 7A20.0 Approved [3]
Sodium oxybate Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Hydroxyacid-oxoacid transhydrogenase (ADHFE1) DE8RJ3F HOT_HUMAN Metabolism [8]
Succinate-semialdehyde dehydrogenase (ALDH5A1) DE5KEWZ SSDH_HUMAN Metabolism [9]
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Sodium oxybate Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Increases Expression [10]
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Indication(s) of Modafinil
Disease Entry ICD 11 Status REF
Malignant glioma 2A00.0 Approved [4]
Methamphetamine dependence 6C46.2 Approved [4]
Narcolepsy 7A20 Approved [5]
Pain MG30-MG3Z Approved [4]
Postpoliomyelitis syndrome N.A. Approved [4]
Traumatic brain injury NA07.Z Approved [4]
Bipolar disorder 6A60 Phase 4 [6]
Brain injury NA07.Z Investigative [7]
Modafinil Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine transporter (DAT) TTVBI8W SC6A3_HUMAN Modulator [11]
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Modafinil Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
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Modafinil Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Affects Response To Substance [13]
Sodium-dependent dopamine transporter (SLC6A3) OT39XG28 SC6A3_HUMAN Affects Response To Substance [14]
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References

1 ClinicalTrials.gov (NCT00066170) Trial Comparing Effects of Xyrem Taken Orally and Modafinil With Placebo in Treating Daytime Sleepiness in Narcolepsy
2 FDA Approved Drug Products from FDA Official Website.
3 Sodium oxybate FDA Label
4 Modafinil FDA Label
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 ClinicalTrials.gov (NCT01965925) Targeting Circadian and Cognitive Dysfunction in Bipolar Disorder With Modafinil. U.S. National Institutes of Health.
7 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
8 Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. J Inherit Metab Dis. 2005;28(6):921-30.
9 Redox-switch modulation of human SSADH by dynamic catalytic loop. EMBO J. 2009 Apr 8;28(7):959-68.
10 Failure of gammahydroxy butyric acid to stimulate growth hormone secretion in cocaine addicts. Neuropeptides. 1997 Oct;31(5):459-62. doi: 10.1016/s0143-4179(97)90040-8.
11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
12 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
13 Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 2010 Aug;33(8):1027-35. doi: 10.1093/sleep/33.8.1027.
14 Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci. 2014 Jan 8;34(2):566-73. doi: 10.1523/JNEUROSCI.4128-13.2014.