Details of the Drug Combinations

General Information of This Drug (ID: DMYK490)

Drug Name

Nepafenac DMYK490

Synonyms

Nevanac; AHR-9434; AL-6515

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nepafenac + Idarubicin	DC2ZN3C	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Diclofenac + Nepafenac	DC2F0WT	Diclofenac	Post Surgical Management	[3]
Difluprednate + Nepafenac	DCTG40W	Difluprednate	Uveitis	[4]
Prednisolone + Nepafenac	DCNRAJM	Prednisolone	Uveitis	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7564).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT02506348) Comparison of Diclofenac vs. Nepafenac Ophthalmic Drops: Patient Comfort
4	ClinicalTrials.gov (NCT01939691) Macular Edema Nepafenac vs. Difluprednate Uveitis Trial