General Information of This Drug (ID: DMYRBO1)

Drug Name
Umbralisib   DMYRBO1
Synonyms RP5264; TGR-1202
Indication
Disease Entry ICD 11 Status REF
Follicular lymphoma 2A80 Approved [1]
Marginal zone lymphoma 2A85.0 Approved [1]
Diffuse large B-cell lymphoma 2A81 Phase 2/3 [2]
Chronic lymphocytic leukaemia 2A82.0 Phase 2 [3]
Non-hodgkin lymphoma 2B33.5 Phase 2 [3]
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

8 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Carfilzomib + Umbralisib DCHS2BT Carfilzomib Hodgkin Disease [4]
Lenalidomide + Umbralisib DC6KJNI Lenalidomide Chronic Lymphocytic Leukemia [5]
Lenalidomide + Umbralisib DCO2C97 Lenalidomide Recurrent B-Cell Non-Hodgkin Lymphoma [6]
Ruxolitinib + Umbralisib DC2JL3F Ruxolitinib Myelofibrosis [7]
Tazemetostat + Umbralisib DC9HD1Z Tazemetostat Recurrent Follicular Lymphoma [8]
Ublituximab + Umbralisib DC3W3HZ Ublituximab Chronic lymphocytic leukaemia; Non-hodgkin lymphoma [9]
Umbralisib + Ibrutinib DC05K5A Ibrutinib Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma [10]
Venetoclax + Umbralisib DC9U6PJ Venetoclax Chronic Lymphocytic Leukemia [5]
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⏷ Show the Full List of 8 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
2 ClinicalTrials.gov (NCT02793583) Study to Assess the Efficacy and Safety of Ublituximab + Umbralisib With or Without Bendamustine and Umbralisib Alone in Patients With Previously Treated Non-Hodgkins Lymphoma (UNITY-NHL). U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 ClinicalTrials.gov (NCT02867618) Carfilzomib and TGR-1202 in Treatment of R/R Lymphoma
5 ClinicalTrials.gov (NCT03379051) Phase I/II Study of Venetoclax or Lenalidomide in Combination With Ublituximab and Umbralisib in Subjects With Relapsed or Refractory CLL/SLL and NHL
6 ClinicalTrials.gov (NCT04635683) Lenalidomide, Umbralisib, and Ublituximab for the Treatment of Relapsed or Refractory Indolent Non-Hodgkin Lymphoma or Mantle Cell Lymphoma
7 ClinicalTrials.gov (NCT02493530) TGR-1202 + Ruxolitinib PMF PPV-MF PET-MF MDS/MPN Polycythemia Vera Resistant to Hydroxyurea
8 ClinicalTrials.gov (NCT05152459) Tazemetostat in Combination With Umbralisib and Ublituximab for the Treatment Relapsed or Refractory Follicular Lymphoma
9 FDA Drug Development and Drug Interactions
10 ClinicalTrials.gov (NCT02268851) A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL