Details of the Drug Combinations

General Information of This Drug (ID: DMZ5RGV)

• Drug Name: Naproxen (DMZ5RGV)
• Synonyms: NAPROXEN; 22204-53-1; (S)-Naproxen; Naproxene; Naprosyn; (+)-Naproxen; Equiproxen; Laraflex; Naproxenum; Naproxeno; d-Naproxen; (S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid; (S)-(+)-Naproxen; Calosen; Nycopren; Naprosyne; Bonyl; Reuxen; Naixan; Axer; (+)-(S)-Naproxen; Ec-Naprosyn; (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid; Flexipen; Clinosyn; Artrixen; Anexopen; Acusprain; Novonaprox; Arthrisil; Leniartil; Danaprox; Bipronyl; Artroxen; Napren; Naposin; Napflam; Genoxen; Daprox; Atiflan; Artagen; Apronax; Naprius; Nalyxan; Lefaine; Congex

Indication

Bursitis; ICD 11: N.A.; Status: Approved [1]; Dysmenorrhea; ICD 11: GA34.3; Status: Approved [1]; Fever; ICD 11: MG26; Status: Approved [1]; Gout; ICD 11: FA25; Status: Approved [1]; Headache; ICD 11: 8A80-8A84; Status: Approved [1]; Migraine disorder; ICD 11: N.A.; Status: Approved [1]; Osteoarthritis; ICD 11: FA00-FA05; Status: Approved [2]; Pain; ICD 11: MG30-MG3Z; Status: Phase 2 [3]; Endometriosis; ICD 11: GA10; Status: Investigative [4]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

13 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aspirin + Naproxen	DCDSOUO	Aspirin	Hematology	[5]
Cyclobenzaprine + Naproxen	DC4VLHT	Cyclobenzaprine	Acute Low Back Pain	[6]
Darexaban maleate + Naproxen	DCJG9AU	Darexaban maleate	Pharmacodynamic Interaction	[7]
Estradiol + Naproxen	DC0RRJI	Estradiol	Menorrhagia	[8]
Lesinurad + Naproxen	DCU646T	Lesinurad	Gout	[9]
Lidocaine + Naproxen	DCH6BSY	Lidocaine	Contraception	[10]
Sumatriptan + Naproxen	DCDCR0L	Sumatriptan	Migraine	[11]
Diazepam + Naproxen	DCJZ3OD	Diazepam	Low Back Pain	[12]
Tramadol + Naproxen	DC38CP4	Tramadol	Acute Pain	[13]
Acetaminophen + Naproxen	DCJBXCK	Acetaminophen	Lyme Arthritis	[14]
Acetaminophen + Naproxen	DCUNBPY	Acetaminophen	Dysmenorrhea	[15]
Duloxetine + Naproxen	DC1SVVF	Duloxetine	Back Pain, Low	[16]
Tramadol + Naproxen	DC5O2LG	Tramadol	Osseointegrated Dental Implantation	[17]

References

• [1] Naproxen FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5230).
• [4] New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
• [5] ClinicalTrials.gov (NCT02229461) Naproxen Sodium/ASA Platelet Study
• [6] ClinicalTrials.gov (NCT01587274) A Randomized Study of Three Medication Regimens for Acute Low Back Pain
• [7] ClinicalTrials.gov (NCT01409603) To Evaluate Whether Naproxen and Darexaban (YM150) Interact in Their Effects
• [8] ClinicalTrials.gov (NCT01165307) Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia
• [9] ClinicalTrials.gov (NCT01884272) NSAID Drug Interaction Study
• [10] ClinicalTrials.gov (NCT02769247) Efficacy of Intrauterine Lidocaine and Naproxen for Pain Control With Intrauterine Device Insertion
• [11] ClinicalTrials.gov (NCT01071317) Trial of Comprehensive Migraine Intervention
• [12] ClinicalTrials.gov (NCT02646124) Diazepam Use With Standard Management for Acute Low Back Pain
• [13] ClinicalTrials.gov (NCT05995912) Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain
• [14] ClinicalTrials.gov (NCT04038346) Symptomatic Management of Lyme Arthritis
• [15] ClinicalTrials.gov (NCT03448536) A Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea
• [16] ClinicalTrials.gov (NCT05851976) Duloxetine for LBP
• [17] ClinicalTrials.gov (NCT04694300) OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients