Details of the Drug Combinations

General Information of This Drug (ID: DMZI3WO)

• Drug Name: Etomidate (DMZI3WO)
• Synonyms: Absele; Amidate; Ethnor; Ethomidate; Etomidato; Etomidatum; Hypnomidate; Radenarcon; Radenarkon; Etomidic acid; R 16659; R 26490; R26490; Amidate (TN); Amidate (pharmaceutical); Amidate, Etomidate; D-Etomidate; Etomidato [INN-Spanish]; Etomidatum [INN-Latin]; R-26490; Etomidate (USAN/INN); Etomidate [USAN:BAN:INN]; Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate; Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; (+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate; (+)-Etomidate; (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester; (d)-Etomidate; 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1-(1-Phenylethyl)-imidazole-5-carboxylic acid, ethyl ester; 1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester; 3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester

Indication

Anaesthesia; ICD 11: 9A78.6; Status: Approved [1]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

47 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acitretin + Etomidate	DCYSHXN	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Brincidofovir + Etomidate	DCAK9K3	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Crotamiton + Etomidate	DCHY7VW	Crotamiton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Cytarabine + Etomidate	DCWQAY0	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Diazoxide + Etomidate	DCNHZHI	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Docetaxel + Etomidate	DCPMS0W	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Doxorubicin + Etomidate	DCCPC2K	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Epinephrine + Etomidate	DCWVKNT	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Kanamycin	DC7Y0OH	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Miglustat	DCJDMY4	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Fomepizole	DCZJ5EQ	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + IT-141	DCZTBPS	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + SCH 727965	DC479IH	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Pazopanib	DC2L2RW	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Ciprofibrate	DCDR0QT	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Nizatidine	DC0TBIQ	Nizatidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Clopidogrel	DCOU6GU	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + BIO-300	DCQU5SP	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Idarubicin	DCCXGKV	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
Etomidate + Imatinib	DCI0PSO	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Methylene blue	DCR8DVW	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Maprotiline	DC8JHYX	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Leflunomide	DCPH133	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Amiloride	DC6LW8Q	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Lacosamide	DCLXWAB	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Cerivastatin	DCQAZZH	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Busulfan	DC4M6CB	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Aciclovir	DCCPP53	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Albendazole	DCER8RW	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Tacrolimus	DCTP1N3	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Etomidate + Cilostazol	DCDTXMA	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Everolimus + Etomidate	DCUIU3R	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mebendazole + Etomidate	DCE8VVN	Mebendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mesalazine + Etomidate	DCC769M	Mesalazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Mycophenolic acid + Etomidate	DC10IWP	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Niclosamide + Etomidate	DCEY6AA	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Olanzapine + Etomidate	DCGM64D	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pinacidil + Etomidate	DCRTG3L	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
PMID28460551-Compound-2 + Etomidate	DCKUF8W	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Pyrazinamide + Etomidate	DCHJFX1	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Tamoxifen + Etomidate	DCJNYB3	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Tiagabine + Etomidate	DCBHAMB	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Trihexyphenidyl + Etomidate	DCAYM09	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Trimethobenzamide + Etomidate	DCD84IT	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Ursodeoxycholic acid + Etomidate	DC0HJQY	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Vinblastine + Etomidate	DCAY8UF	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]
Vorinostat + Etomidate	DCU0A7M	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[2]

7 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Fentanyl + Etomidate	DCS7FMK	Fentanyl	Complication of Gastrostomy	[3]
Methylprednisolone + Etomidate	DCM66AY	Methylprednisolone	Adrenocortical Deficiency	[4]
Oxytocin + Etomidate	DCULI8G	Oxytocin	Postpartum Hemorrhage	[5]
Etomidate + Sevoflurane	DC6T6OA	Sevoflurane	Anesthesia	[6]
Midazolam + Etomidate	DCTGQ7S	Midazolam	Congenital Hydronephrosis	[7]
Propofol + Etomidate	DC5XG17	Propofol	Surgery	[8]
Propofol + Etomidate	DCI164K	Propofol	Target Controlled Infusion	[9]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5463).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT01729897) Etomidate Emulsion for Sedation in Patients Scheduled for Upper Gastrointestinal (GI) Endoscopy
• [4] ClinicalTrials.gov (NCT01792037) Single Dose of Etomidate and Adrenal Cortex
• [5] ClinicalTrials.gov (NCT03852797) Spontaneous and Oxytocin-induced Contractility After Exposure to Intravenous Anesthetic Agents: an In-vitro Study in Human Myometrium
• [6] ClinicalTrials.gov (NCT02500225) Comparison the Effects of Etomidate and Sevoflurane During Electroconvulsive Therapy
• [7] ClinicalTrials.gov (NCT02013986) Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children
• [8] ClinicalTrials.gov (NCT03820388) Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia
• [9] ClinicalTrials.gov (NCT02174120) The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries