Details of the Drug Formulations

General Information of Drug (ID: DM1BV7W)

• Drug Name: Aliskiren Drug Info
• Synonyms: Rasilez; SPP 100; Rasilez (TN); Tekturna (TN); Aliskiren (USAN/INN); (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-2-(propan-2-yl)nonanamide; (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide; (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide; Octanamide, .delta.-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-.gamma.-hydroxy-4-methoxy-3-(3-methoxypropoxy)-.alpha.,.zeta.-bis(1-methylethyl)-, [.alpha.S-(alpha.R*,.gamma.R*,.delta.R*,.zeta.R*)]

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1] , [2] , [3]

• Therapeutic Class: Antihypertensive Agents
• Cross-matching ID:
  PubChem CID: 5493444
  ChEBI ID: CHEBI:601027
  CAS Number: 173334-57-1
  TTD ID: D03SVX
  VARIDT ID: DR00061
  INTEDE ID: DR0065
  ACDINA ID: D00019

Full List of Drug Formulations Containing This Drug

Aliskiren Hemifumarate eq 150mg base tablet

Company	Formulation ID	FDA Description
Noden Pharma	F23935	Crospovidone; Magnesium Stearate; Microcrystalline Cellulose; Povidone; Silica; Colloidal Anhydrous; Hypromellose; Macrogol; Talc; Iron Oxide, Black (E172); Iron Oxide, Red (E172); Titanium Dioxide (E171)

Aliskiren Hemifumarate eq 300mg base tablet

Company	Formulation ID	FDA Description
Noden Pharma	F23936	Crospovidone; Magnesium Stearate; Microcrystalline Cellulose; Povidone; Silica; Colloidal Anhydrous; Hypromellose; Macrogol; Talc; Iron Oxide, Black (E172); Iron Oxide, Red (E172); Titanium Dioxide (E171)

Aliskiren Hemifumarate eq 37.5mg base capsule

Company	Formulation ID	FDA Description
Noden Pharma	F23375	Basic Butylated Methacrylate Copolymer; Basic Colloidal Silicon Dioxide; Crospovidone; Povi Done; Dibutyl Sebacate; Magnesium Stearate; Microcrystalline Cellulose; Sodium Lauryl Sulphate

Aliskiren 150 mg tablet

Company	Formulation ID	FDA Description
Avera McKennan Hospital; Noden Pharma USA; Novartis Pharmaceuticals Corporation	F00675	Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
Physicians Total Care	F00676	Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Crospovidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Silicon dioxide, colloidal

Aliskiren 300 mg tablet

Company	Formulation ID	FDA Description
A-S Medication Solutions; Noden Pharma USA; Novartis Pharmaceuticals Corporation	F00677	Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Crospovidone; Silicon dioxide; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycols
Physicians Total Care	F00678	Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Crospovidone; Cellulose, microcrystalline; Hypromelloses; Polyethylene glycol; Silicon dioxide, colloidal
A-S Medication Solutions	F00679	Magnesium stearate; Ferric oxide red; Ferrosoferric oxide; Talc; Titanium dioxide; Silicon dioxide; Crospovidone (15 mpa.s at 5%); Hypromellose, unspecified; Microcrystalline cellulose; Polyethylene glycol, unspecified

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4812).
• [2] 2007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
• [3] Agents in development for the treatment of diabetic nephropathy. Expert Opin Emerg Drugs. 2008 Sep;13(3):447-63.