Details of the Drug Formulations

General Information of Drug (ID: DMXZRW0)

• Drug Name: DTI-015 Drug Info
• Synonyms: Carmustine; carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; Gliadel; BiCNU; Bi CNU; Carmustinum; Bischlorethylnitrosurea; Bischlorethylnitrosourea; Carmustina; Becenun; Becenum; Bischloroethyl nitrosourea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bis(2-chloroethyl)nitrosourea; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Gliadel Wafer; FDA 0345; Bischloroethylnitrosourea; SRI 1720; 1,3-Bis(2-chloroethyl)nitrosourea; BiCNU (TN); Carmustinum [INN-Latin]; Carmustina [INN-Spanish]; DTI 015; NCI-C04773; SK; BCNU; Injectable carmustine, Direct Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Brain cancer	2A00	Approved	[1]
Glioblastoma of brain	2A00.00	Approved	[2]
Liver cancer	2C12	Approved	[3]
Malignant glioma	2A00.0	Approved	[4]
Plasma cell myeloma	2A83.1	Approved	[5]
Classic Hodgkin lymphoma		Investigative	[5]

• Cross-matching ID:
  PubChem CID: 2578
  ChEBI ID: CHEBI:3423
  CAS Number: 154-93-8
  TTD ID: D01OXI
  INTEDE ID: DR0278
  ACDINA ID: D00918

Full List of Drug Formulations Containing This Drug

Carmustine 100mg/vial injectable

Company	Formulation ID	FDA Description
Emcure Pharms Ltd	F23667	Dehydrated Alcohol Injection

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6800).
• [2] Levels and distribution of BCNU in GBM tumors following intratumoral injection of DTI-015 (BCNU-ethanol). Neuro Oncol. 2007 Jan;9(1):12-9.
• [3] Carmustine-induced toxicity, DNA crosslinking and O6-methylguanine-DNA methyltransferase activity in two human lung cancer cell lines. Eur J Cancer. 1991;27(12):1658-62.
• [4] Stereotactic injection of DTI-015 into recurrent malignant gliomas: phase I/II trial. Neoplasia. 2003 Jan-Feb;5(1):9-16.
• [5] A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.