Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM02V5Q)

Drug Name
Diamidothiazole derivative 1 Drug Info
Synonyms PMID26161698-Compound-53
Cross-matching ID
PubChem CID
25256147
TTD Drug ID
DM02V5Q

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aurora kinase (AURK) TTCY4SB NOUNIPROTAC Inhibitor [1]
Checkpoint kinase-1 (CHK1) TTTU902 CHK1_HUMAN Inhibitor [1]
Cyclin-dependent kinase 2 (CDK2) TT7HF4W CDK2_HUMAN Inhibitor [1]
ERK activator kinase 1 (MEK1) TTIDAPM MP2K1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Checkpoint kinase-1 (CHK1) DTT CHEK1 4.267 4.629 3.739 5.322
ERK activator kinase 1 (MEK1) DTT MAP2K1 8.617 7.493 7.334 6.969
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Checkpoint kinase-1 (CHK1) DTT CHEK1 7.22E-191 1.43 4.74
Cyclin-dependent kinase 2 (CDK2) DTT CDK2 2.28E-06 0.12 0.19
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.