Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM03526)

• Drug Name: PD-144550 Drug Info
• Synonyms: 148553-51-9; (R)-Pregabalin; (3R)-3-(aminomethyl)-5-methylhexanoic acid; PD-144550; CHEMBL167003; (R)-3-(Aminomethyl)-5-methylhexanoic acid; ent-Pregabalin; R-Pregabalin; AC1L2PDQ; BSPBio_002316; SCHEMBL263450; SPECTRUM1505816; DTXSID90276292; HMS1922H16; Pharmakon1600-01505816; HMS2093F10; ZINC5760031; TOS-0910; CCG-40213; NSC759256; AKOS027425242; NSC-759256; NCGC00178709-01; SC-94803; SBI-0206875.P001; PD 144550; FT-0674010; FT-0600823; K-4720; Hexanoic acid, 3-(aminomethyl)-5-methyl-, (3R)-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 125889
  CAS Number: CAS 148553-51-9
  TTD Drug ID: DM03526

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	TTFK1JQ	CA2D1_HUMAN	Inhibitor	[1]
Voltage-gated calcium channel alpha-2/delta-2 (CACNA2D2)	TTU8P3M	CA2D2_HUMAN	Inhibitor	[1]
Voltage-gated calcium channel alpha-2/delta-3 (CACNA2D3)	TTN7T29	CA2D3_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	5.083	4.833	5.343	2.536

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	9.36E-01	-0.03	-0.13
Voltage-gated calcium channel alpha-2/delta-1 (CACNA2D1)	DTT	CACNA2D1	2.81E-05	-0.15	-0.68

References

• [1] Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant, Bioorg. Med. Chem. Lett. 4(6):823-826 (1994).